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"Formation and roles of the 5',8-cyclo-2'-deoxyguanosine lesion" (CYCLOGUO)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,
"Free radical attack to genetic material leads to damages that are involved in pathologies as well as in aging. Guanine is the preferred oxidation site of DNA, and 8-oxo-dG is used as marker of radical stress, with some drawbacks due to oxidative artefacts during the analysis. The project addresses the chemical biology of 5’,8-cyclo-2’-deoxyguanosine (5’,8-cyclo-dG), a tandem damage produced by fr ...
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