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19 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerativ ...
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 23

 TERMINÉ 

Vaccination against Shigella and ETEC: novel antigens, novel approaches (STOPENTERICS)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2017,

To contribute to the development of vaccines against Shigella and ETEC for children of the developing world, STOPENTERICS will provide novel solutions by imposing a two-fold paradigm switch: (i) to break the dogma of serotype-specificity by inducing a cross-protective immunity (ii) to improve the immunogenicity of Shigella glycoconjugates by using synthetic oligosacharides mimicking the lipopolysa ...
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 20

 TERMINÉ 

Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2017,

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most rele ...
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 27

 TERMINÉ 

European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Date du début: 1 mars 2012, Date de fin: 30 juin 2016,

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n ...
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 18

 TERMINÉ 

Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia (NEUROSIS)

Date du début: 1 mars 2009, Date de fin: 31 août 2015,

HYPOTHESIS: Early inhalation of Budesonide (BS) reduces the absolute risk of developing bronchopulmonary dysplasia (BPD) or death in preterm infants born between 23 and 27 weeks gestational age (GA) by 10%. PRIMARY OBJECTIVE: Survival without BPD at 36 weeks GA. SECONDARY OBJECTIVES: (1) neurodevelopment at a corrected age of 18-22 months; (2) adverse treatment effects; (3) mortality at 36 weeks G ...
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 15

 TERMINÉ 

Regenerating Bone defects using New biomedical Engineering approaches (REBORNE)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autogra ...
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 24

 TERMINÉ 

SAFER AND FASTER EVIDENCE-BASED TRANSLATION (SAFE-T)

Date du début: 15 juin 2009, Date de fin: 14 juin 2015,

The public-private consortium composed of complementary SMEs, academic and clinical centers of excellence and EMEA as partner proposes SAFE-T (Safer And Easter Evidence-based Iranslation) project for the establishment of a biomarker (BM) qualification process and its validation in clinical biomarker studies designed for the translation, performance testing and eventual regulatory qualifIcatIon of ...
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 26

 TERMINÉ 

Suicidality: Treatment Occurring in Paediatrics (STOP)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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 19

 TERMINÉ 

Paediatric European Risperidone Studies (PERS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

"Second-generation antipsychotics are increasingly being prescribed to children and adolescents. Their use, however, is mostly off-label, and adequate and sufficient data about efficacy and particular safety are lacking. This proposal focuses on two indications, the use of risperidone in children and adolescents with conduct disorder who are not mentally retarded, and the use of risperidone in ado ...
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 22

 TERMINÉ 

Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide (NEMO)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in 2-3/1000 live births and is a major cause of both acute mortality and long-term neurodisability. Seizures are the hallmark of HIE. The clinical and electrographic seizure burden in babies with HIE can be considerable and is often not reduced by current antiepileptic drugs. Phenobarbitone remains the first line drug for neonatal seizures des ...
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 15

 TERMINÉ 

Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria (SATURN)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

"Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of antimicrobial resistance (AMR) have lacked a holistic view combining all aspects into one study. The SATURN project aims to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. Two ...
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 16

 TERMINÉ 

Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics (PREDICT)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

"The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of t ...
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 16

 TERMINÉ 

No Pain during infancy by adapting off-patent medicines (NeoOpioid)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2013,

Preterm and newborn infant may suffer from pain in the same way as adults. They are even more sensitive to pain due to immaturity of endogenous modulation. Thus, they should have the same human right to be alleviated from pain. The overall aim of this project is to assess effects and safety of opioid treatment in very preterm up to full term newborn infants in relation to pharmacokinetics predisp ...
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 13

 TERMINÉ 

Fatty liver: Inhibition of Progression (FLIP)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

"Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepatogastroenterologist due to the obesity epidemic and its potential to progress to advanced liver disease which significantly impacts on overall and liver-related mortality. The aim of the FLIP (Fatty Liver: Inhibition of Progression) project is to understand and prevent the progression of liver dis ...
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 17

 TERMINÉ 

Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE)

Date du début: 1 juin 2009, Date de fin: 30 nov. 2012,

Recombinant growth hormone (GH) has been used since 1985. Current indications for GH use in children include GH deficiency and an increasing number of conditions where childhood short stature is not primarily due to deficient GH secretion. Approximately 40 000 children in the EU are treated with daily injections of GH. The efficacy of GH to increase adult height is undisputed in children with seve ...
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 10

 TERMINÉ 

Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease (EVINCI-study)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumora ...
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 22

 TERMINÉ 

Development of 6-mercaptopurine and Methotrexate oral liquid formulations for the maintenance treatment of Acute Lymphoblastic Leukæmia in children (LOULLA&PHILLA)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2012,

"Only for Children Pharmaceuticals, a French based Small and Medium-sized Enterprise (SME) developing drug for children, is the Coordinator of a multinational, multidisciplinary and complementary Consortium. This Consortium is composed of highly qualified organizations and notorious clinicians in pediatric hemato-oncology. The Consortium is an integrated team of competencies (clinicians, pædiatric ...
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 12

 TERMINÉ 

Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics (Mitotarget)

Date du début: 1 févr. 2009, Date de fin: 31 mars 2012,

Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question re ...
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 19

 TERMINÉ 

Services and Health for Elderly in Long TERm care (SHELTER)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,

"One of the most relevant obstacle to assess and compare nursing home (NH) services and patients across countries relates to the fact that standardized and validated methodologies are not routinely in use in daily practice in Europe. The Minimum Data Set (MDS) is a comprehensive assessment instrument which contains a standardized set of essential clinical and functional status measures and allows ...
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 8