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 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 24

 TERMINÉ 

Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The current healthcare systems are built around the traditional paradigm of patients suffering from a single acute illness. They are therefore largely unprepared to face the increasing demands for health services arising from the expansion of an older population with specific medical needs related to multiple chronic disorders. As a consequence, the medical conditions of a large and growing seg ...
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 27

 TERMINÉ 

A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer (GANNET53)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2019,

"Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours, which are characterised by a high frequency of p53 mutations, and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. With current standard therapy the median overall survi ...
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 20

 TERMINÉ 

The Molecular Anatomy of Neurons (NeuroMolAnatomy)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

The brain is nowadays the object of a number of extensive systematic studies that focus on seemingly all aspects of its morphology and function, from overall brain architecture to neuronal connections, neuronal morphology and gene expression. However, at least one basic aspect is as yet incompletely studied: the molecular anatomy of the neuron, i.e., the copy numbers and the spatial arrangement of ...
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 1

 TERMINÉ 

Mitochondrial translational regulation coupled to respiratory chain assembly and protein import (MITRAC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Mitochondrial respiratory chain complexes assemble from nuclear- and mitochondria-encoded subunits in the inner membrane. To protect cells from accumulating unassembled subunits in the membrane, ROS generation, or damage of mitochondrial integrity, regulatory mechanisms to balance and control the fidelity of the assembly process have evolved, encorporating a retention system enabling the preserva ...
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 1

 TERMINÉ 

"Mitochondria, Peroxisomes and Lysosomes - the ""menage a trois"" of cellular metabolism" (MITOPEXLYSONETWORK)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

The metabolic roles of mitochondria, peroxisomes and lysosomes are well established. Numerous genetic defects affecting the function of these organelles result in a wide spectrum of metabolic diseases. The involvement of these organelles in signalling pathways is receiving increasing attention. Furthermore, interactions between them and other cellular components have been elucidated. Evidence is n ...
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 1

 TERMINÉ 

Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity (MU TUNING)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber contractions they elicit. The MN-muscle fiber units display marked plasticity towards chronically altered physical activity ...
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 1

 TERMINÉ 

The biogenesis of tail-anchored membrane proteins: knowledge and exploitation (TAMPTING)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to creat ...
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 8

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Molecular Mechanisms of Fungal Pathogen Host Interactions (ImResFun)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

ImResFun shall provide state-of-the-art training in infectious disease research and medical immunology targeting the most common human fungal pathogens, the opportunistic Candida species. The key objectives of ImResFun are: (i) to understand how immune cells and infected organs respond to invasion by Candida spp, (ii) to decipher host-defense mechanisms mediating pathogen elimination, and (iii) to ...
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 12

 TERMINÉ 

Innovative methodology for small populations research (InSPiRe)

Date du début: 1 févr. 2014, Date de fin: 31 mai 2017,

The HEALTH.2013.4.2-3 call identifies a need for new or improved statistical methodology for clinical trials for the efficient assessment of safety and/or efficacy of treatment for small population groups. This project brings together international experts in innovative clinical trial design methodology in these specific areas along with key stakeholders including regulatory authorities, industry ...
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 9

 TERMINÉ 

Clinical European study on the outcome of surgical and hormonal therapy and psychological intervention in disorders of sex development (DSD) (DSD-LIFE)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2017,

Disorders of sex development (DSD) are a conglomerate of rare diseases with an estimated incidence of 1: 4500. The causes of DSD are mainly disorders with gonadal dysgenesis, decreased androgen synthesis or function in XY males or disorders with elevated androgen production in XX females. Decision on sex of rearing is difficult in some cases as the prenatal androgen imbalances result in ambiguous ...
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 17

 TERMINÉ 

Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies (CELLEUROPE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is ...
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 13

 TERMINÉ 

DECODING THE NEURAL CODE OF HUMAN MOVEMENTS FOR A NEW GENERATION OF MAN-MACHINE INTERFACES (DEMOVE)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2016,

"The generation of a movement is the combination of discrete events (action potentials) generated in the brain, spinal cord, nerves, and muscles. These discrete events are the result of ion exchanges across membranes, electrochemical mechanisms, and active ion pumping through energy expenditure. The ensemble of spike trains discharged in the various parts of the neuromuscular system constitutes th ...
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 1

 TERMINÉ 

Disc-shaped point-of-care platform for infectious disease diagnosis (DiscoGnosis)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,

The project aims to develop a fully integrated, automated and user-friendly platform for infectious disease diagnosis. Malaria can be treated in just 48 hours, but delayed or false diagnosis or missing a relevant alternative cause of fever may be lethal. Therefore, other diseases with similar clinical symptoms will be investigated too. DiscoGnosis will integrate micro, nano, and bio components int ...
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 8

 TERMINÉ 

MYOELECTRIC INTERFACING WITH SENSORY-MOTOR INTEGRATION (MYOSENS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

"Biological signals recorded from the human body can be translated into actions of external devices to create man-machine interaction. This concept has clinical implications in rehabilitation technologies for replacing or recovering impaired motor functions. Among the possible biosignals for man-machine interaction (brain, nerve, and muscle signals), muscle signals, i.e. electromyography (EMG), ar ...
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 5

 TERMINÉ 

VISUAL MODELLING USING GANGLION CELLS (VISUALISE)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2016,

The processing capabilities of biological visual systems are still vastly superior in terms of performance for real-time and low-power applications compared with conventional artificial vision. There is increasing evidence that biology has evolved a multitude of cell types, including at the level of the retina, to adapt to an extensive set of dynamic visual environments. Existing bio-inspired arti ...
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 5

 TERMINÉ 

Modulation of synaptic plasticity and circuit function by regulation of neurotrophin exocytosis (SYT ACTIVITY)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

A fundamental question in neuroscience is how individual synapses and neurons act in concert to create functional circuits. While the basic mechanisms of synaptic transmission between neurons are well understood, much less is known about how individual synapses, neurons, and circuits dynamically adjust their transmission properties in response to perturbations in network activity. During the past ...
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 1

 TERMINÉ 

Novel biomimetic strategy for bone regeneration (INNOVABONE)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Our overall approa ...
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 14

 TERMINÉ 

Joint European and South African Research Network in Anxiety Disorders (EUSARNAD)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

The overall aim of our proposal is to build on the strengths of an existing European network for research into causes and maintaining factors in anxiety disorders and to extend these by establishing firmer research collaboration with the University of Cape Town in South Africa.Through establishing this research exchange, we aim to share knowledge and expertise among participating centres, and ensu ...
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 13

 TERMINÉ 

A portable device for Early detection and treatment of Traumatic Brain Injury based on advanced qEEG and HD-TES to prevent major Health problems and specially for use in emergencies and telemedicine (EMEREEG)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2015,

Traumatic Brain Injury (TBI) is recognized as a major public health concern, especially for teenagers and young adults, since it can lead to significant disruption in education, working ability, and quality-of-life in general. It is one of the leading causes of death and disability worldwide. 1.2 million EU citizens are hospitalized with TBI each year and of which 50.000 die. The total economic bu ...
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 8

 TERMINÉ 

Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Date du début: 1 sept. 2010, Date de fin: 31 août 2015,

Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in bio ...
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 19

 TERMINÉ 

Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia (NEUROSIS)

Date du début: 1 mars 2009, Date de fin: 31 août 2015,

HYPOTHESIS: Early inhalation of Budesonide (BS) reduces the absolute risk of developing bronchopulmonary dysplasia (BPD) or death in preterm infants born between 23 and 27 weeks gestational age (GA) by 10%. PRIMARY OBJECTIVE: Survival without BPD at 36 weeks GA. SECONDARY OBJECTIVES: (1) neurodevelopment at a corrected age of 18-22 months; (2) adverse treatment effects; (3) mortality at 36 weeks G ...
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 15

 TERMINÉ 

Crimean Congo Hemorrhagic Fever; Modern Approaches to Diagnostics, Surveillance, Prevention, Therapy and Preparedness (CCH Fever)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

Over the last years, large outbreaks of Crimean Congo Hemorrhagic fever virus (CCHFV) in several European countries and neighbouring areas are on the rise. This disease poses a great threat to public health due to its high mortality rate, modes of transmission and geographical distribution. Climate changes and observation of the CCHFV vector in central Europe alarm the European community as we can ...
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 18

 TERMINÉ 

Identification and therapeutic targeting of common arrhythmia trigger mechanisms (EUTRIGTREAT)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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 15

 TERMINÉ 

Micro and Nano Engineered Bi-Directional Carbon Interfaces for Advanced Peripheral Nervous System Prosthetics and Hybrid Bionics (MERIDIAN)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,

The main goal of this proposal is to bring novel technology of biocompatible, low bio-fouling, high electrochemical performance carbon nanomaterials to in-vivo preclinical applications and at the same time to use this materials to develop a highly advanced concept of intimate intracellular contact, based on bottom - up technology of, engulfing the micro-electrode by neural cells. Such bionic inter ...
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 11

 TERMINÉ 

A novel concept for support to diagnosis and remote management of tremor (NeuroTREMOR)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,

Tremor is the most common movement disorder and is strongly increasing in incidence and prevalence with ageing. The most frequent types of tremor are those arising from two neurodegenerative disorders: Parkinson's disease and essential tremor. Although not life threatening, upper limb tremors hamper independent life of 65% of those suffering from them, greatly impacting on their quality of life. T ...
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 7

 TERMINÉ 

Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

"Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atyp ...
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 21

 TERMINÉ 

Advanced Myoelectric Control of Prosthetic Systems (AMYO)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

In spite of decades of research and many capabilities and potentials as well as incremental improvements, advanced human-maschine interfaces based on the electromyogram (EMG) still have a significant distance from professional and commercial applications. This is also and particularly true for myoelectric prosthetic devices. Available commercial myoelectric control systems for prostheses can only ...
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 6

 TERMINÉ 

The Interaction between the Central and Peripheral Exercise-Related Fatigue (ICPEF)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

"Understanding the complex interactions between the fatigue and neuromuscular activation has been under intensive research for more than a century. Nevertheless, it remains one of the most challenging research topics in neurophysiology. The factors influencing the development of fatigue involve both peripheral (muscle) and central (spinal and supraspinal) aspects but their complex interactions are ...
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 1

 TERMINÉ 

Synapses: from molecules to higher brain function and diseases (SYMBAD)

Date du début: 1 déc. 2009, Date de fin: 28 févr. 2014,

SyMBaD aims to move forward our knowledge on synapse structure and function in the normal and pathological brain. Brain diseases represent a considerable social and economic burden in Europe. Emerging evidence indicates that synaptic dysfunction is associated with a majority of neurological and psychiatric disorders. Novel therapeutical approaches relie on a better knowledge of the synapse and its ...
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 13

 TERMINÉ 

The Synapse Nanomap (Nanomap)

Date du début: 1 sept. 2008, Date de fin: 31 août 2013,

Stimulated Emission Depletion (STED) microscopy is one of the most important recent developments in light microscopy (Willig et al., 2006, Nature 440:935-9). STED allows for imaging cellular elements with diffraction-unlimited resolution; in practical terms, the resolution (normally limited to ~200-300 nm) is improved down to 30-60 nm. Together with the development of two-color STED microscopy (Do ...
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 1

 TERMINÉ 

Public Private Partnership for Asthma Imaging and Genomics (P3AGI)

Date du début: 1 août 2009, Date de fin: 31 juil. 2013,

The main objective of this project is to develop a research network that includes both private and public institutions focused on the exchange of expertise in imaging, genomics and bioinformatics to be utilized in monitoring therapies and disease progression in severe allergic asthma (AA): • Aeirtec, a research-service SME with Hu-SCID in vivo models of AA that would benefit from academic expertis ...
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 5

 TERMINÉ 

Innate and adaptive immune responses to nanocell-based tumor-targeted cancer therapeutics (CD14)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2013,

"According to the project ‘Fighting against cancer today’ (FACT, funded by the EU 2008), molecularly targeted drugs with associated sophisticated diagnostic systems to personalize care are likely to have a great impact on cancer control in Europe. At the same time, drug delivery is going to be progressed by nanomedicines that can ferry high amounts of active drugs to the tumor. A recent achievemen ...
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 1

 TERMINÉ 

BNCI-driven Robotic Physical Therapies in Stroke Rehabilitation of Gait Disorders (BETTER)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2013,

Cerebral vascular accident (CVA, Stroke) is the most prevalent neurological condition leading to physical impairment in Western society. About 4.7 million stroke survivors are alive today. Impaired walking ability contributes to post-stroke walking disability. Walking incorrectly creates a stigma and makes patients more susceptible to injury, affecting quality of life. Most promising interventions ...
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 10

 TERMINÉ 

Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease (LipidomicNet)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2012,

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quan ...
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 27

 TERMINÉ 

Personalized health monitoring (PHM)- Interdisciplinary research to analyse the relationship between ethics, law and psychosocial as well as medical sciences (PHM-Ethics)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2012,

The aim of PHM-Ethics is to scientifically analyse the dependencies between ethics, law and psychosocial sciences in a dynamic part of IT development, i.e. personalized health monitoring (PHM), from a European perspective. First, the development of PHM will be reviewed to identify core steps that delineate major changes from an ethical, legal and psychosocial point of view. A taxonomy will be elab ...
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 7

 TERMINÉ 

Advanced gene therapy tools for treatment of CNS-specific disorders (NEUGENE)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Curative therapies still do not exist for most CNS diseases but gene therapy is a promising new approach. We propose that it will be possible to modify brain function and pathophysiology by targeted delivery of specific curative factors to selected populations of brain cells that are affected by disease. This opens the door for effective treatment regimes, which can be tailored to individual pati ...
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 6

 TERMINÉ 

The Pathophysiology and Natural Course of Patients with Primary Antibody Deficiencies (PAD) (EURO-PADnet)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,

This medium-sized collaborative project will document and monitor the natural course and study the pathophysiology of Primary Antibody Deficiencies (PAD). PADs are rare inborn errors of the immune system with an estimated incidence of
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 13