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28 projets européens trouvés

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 TERMINÉ 

Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery (ULTRA-DD)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

ULTRA-DD (Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery) will be an European-wide, highly collaborative and inclusive consortium, to validate new targets for drug discovery by (1) generating high quality research tools, with an emphasis on chemical probes; (2) generating the chemical probes in the most cost-effective manner, using structure-guided methods and harne ...
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 10

 TERMINÉ 

Vaccination In Atherosclerosis (VIA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Cardiovascular disease (CVD) is still a leading cause of death in the European Union (EU) accounting for nearly half of all deaths in Europe (48%). In addition, CVD complications lead to a vast number of hospitalizations and thus to a great burden of health care costs in the EU. Atherosclerosis and its final complication, plaque rupture and subsequent infarct in heart or brain, is the main underl ...
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 12

 TERMINÉ 

Treating stroke with Affibody molecules targeting the inflammatory mediator HMGB1 (COUNTERSTROKE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 perso ...
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 6

 TERMINÉ 

Targeting and exploiting B cell functions for treatment in cardiovascular disease (Athero-B-Cell)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Cardiovascular disease (CVD) mortality and morbidity is predicted to increase in Europe and worldwide in the next decades due to aging and the rise of diabetes and obesity. The link between metabolic and inflammatory disease is getting stronger, raising hopes for novel therapeutic targets to be exploited clinically. Clinical evidence generated by the Academic partners of the Athero-B-Cell Consorti ...
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 11

 TERMINÉ 

Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics. The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct cer ...
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 12

 TERMINÉ 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Regulation of gene expression in sebaceous glands (RNAsebgland)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2017,

In the pathogenesis of dermal inflammation, sebaceous glands (SGs) were considered as impotent players that are under the control of other cell types, but without any feedback on them. Only research of the past decade put SGs into our focus showing that besides their contribution to the lipid layer covering the skin surface and the hair, SGs are also capable of exerting inflammatory responses, thu ...
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 1

 TERMINÉ 

"King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies." (TRIGGER)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwid ...
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 11

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

Towards Early diagnosis and biomarker validation in Arthritis Management (EURO-TEAM)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

An ideal intervention in a chronic inflammatory disease such as Rheumatoid Arthritis (RA) would be a preventive one. In order to develop preventive strategies and therapies two key developments need to occur: (1) Biomarkers need to be identified that can be used to predict an individual’s risk of developing RA. (2) Modifiable disease mechanisms need to be identified and characterized in the early ...
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 17

 TERMINÉ 

Rheumatoid Arthritis and Periodontal Inflammatory Disease (RAPID) (RAPID)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

"The most prevalent chronic inflammatory diseases of humans are complex disorders of multifactorial aetiology influenced by genes, the environment and their interactions. Periodontitis (PD) and rheumatoid arthritis (RA) are two such chronic inflammatory diseases associated withsignificant morbidity and mortality, and have recently shown to have a bi-directional association. Moreover, the prevalenc ...
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 15

 TERMINÉ 

Genes, environment and immunity in the pathogenesis of rheumatoid arthritis (PreventRA)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2016,

Aims and significance: The aims of this program are (1) To obtain new understanding of how environmental and life style factors interact with genes to induce immune reactions able to cause the different forms of arthritis that are defined as RA; (2) To use this understanding to develop prevention and targeted therapy for different forms of RA, and to enable efficient and eventually curative therap ...
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 1

 TERMINÉ 

Kinetic analysis of molecular profiles during human induced regulatory T cell (iTreg) differentiation: an integrative study (ITREGDIFFERENTIATION)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2015,

Regulatory T cells (Tregs) suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance, preventing autoimmune disease but hampering tumor rejection. Therapeutic manipulations of Treg number and function are therefore subject to numerous clinical investigations. First in-man trials of adoptive Treg transfer to prevent graft-versus-host disease showed very promising ou ...
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 1

 TERMINÉ 

CAncer Risk and INsulin analoGues (CARING)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

"Several studies have linked the use of insulins to the risk of cancer, and it is certainly plausible that as a growth factor, exposure to administered insulin could stimulate neoplastic growth. However, the meta-analyses of randomized clinical trials comparing different insulin analogues were too small to quantify the risks, especially the proportion of patients that were followed for more than ...
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 8

 TERMINÉ 

SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2015,

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
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 27

 TERMINÉ 

Protein citrullination as a link between periodontal diseases and rheumatoid arthritis (RA) and target for development of novel drugs to treat RA (GUMS AND JOINTS)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

Autoimmunity in rheumatoid arthritis (RA) is characterised by an antibody response to citrullinated proteins. Periodontitis (PD) is largely caused by infection, in whichPorphyromonas gingivalis is a major pathogen. The two diseases combine specific HLA-DRB1alleles and smoking as risk factors, and have a similar pathophysiology characterised by destructive inflammation. A possible causative link be ...
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 14

 TERMINÉ 

Modelling and simulation environment for systems medicine\n(Chronic obstructive pulmonary disease -COPD- as a use case) (SYNERGY-COPD)

Date du début: 1 févr. 2011, Date de fin: 30 avr. 2014,

Synergy will develop a simulation environment and a decision-support system aiming at enabling deployment of systems medicine. The three core elements are a knowledge base (KB), an inference engine (IE), and a graphical visualisation environment (GVE). The project focuses on patients with chronic obstructive pulmonary disease (COPD).The KB will include five well established physiological models ad ...
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 9

 TERMINÉ 

Treatment of reperfusion injury using a mitochondrial targeted approach: towards a better understanding of the disease (MITOCARE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

"Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperf ...
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 18

 TERMINÉ 

European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2013,

"The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the developmen ...
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 19

 TERMINÉ 

Prevent Rheumatoid Arthritis in Practice (PRACTICE)

Date du début: 1 sept. 2012, Date de fin: 31 août 2013,

The idea is to develop vaccines and companion diagnostics for treatment of rheumatoid arthritis (RA). The idea is built on (i) knowledge that the immune systems harbors a capacity for specific reregulation of its actions, both in increasing its actions (e.g. existing vaccination against polio, measles etc.) and in decreasing its actions (“vaccinations” against autoimmune diseases, which has so far ...
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 1

 TERMINÉ 

Deciphering the molecular basis of regulatory T cell suppression (TREG suppression)

Date du début: 1 sept. 2009, Date de fin: 31 août 2013,

Regulatory T cells (TREG) comprise a subset of CD4+ T cells that maintain immunological tolerance by suppressing immune activation in a dominant manner. TREG helps shaping the immune responses to autoantigens, alloantigens, tumors, pathogens and allergens, and are thus considered a therapeutical target in a large variety of diseases. One aspect of TREG biology that remains poorly understood is wh ...
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 1

 TERMINÉ 

Virtual Physiological Human Network of Excellence (VPH NoE)

Date du début: 1 juin 2008, Date de fin: 31 mai 2013,

Description The Virtual Physiological Human Network of Excellence (VPH NoE), 2008-2013, served as a rallying point and source of best-practice information for the VPH community.  This role has now has been passed to the VPH Institute (http://www.vph-institute.org/).  The tools and educational/outreach materials developed by the VPH NoE – and ...
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 23

 TERMINÉ 

Identification of New Genetic Determinants of Plasma Fibrinogen Concentration (INDEFIC)

Date du début: 1 juil. 2010, Date de fin: 28 févr. 2013,

"The proposed project aims at the identification and characterization of novel genes, genetic variants and pathways implicated in the regulation of plasma fibrinogen concentration, which is an independent risk factor for cardiovascular disease (CVD). Several genome-wide linkage and association studies have identified some interesting regions which may contain candidate genes that are not yet ident ...
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 1

 TERMINÉ 

Influence of the in utero environment on the risk of allergy development for the child (Inuteral)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2010,

Today allergies are a major public health problem. Previous cross-sectional studies have found that children growing up with an anthroposophic lifestyle have a lower prevalence of IgE-mediated allergic diseases. This observation strengthens the hypothesis on importance of interaction between environment and our immune system during early childhood regarding allergy. The focus of this project is to ...
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 1

 TERMINÉ 

"GENOME-WIDE CHARACTERIZATION OF TRANSCRIPTIONAL REGULATORY ELEMENTS, PATHWAYS AND ASSOCIATED GENETIC VARIATIONS INVOLVED IN THE PATHOGENESIS OF CORONARY ARTERY DISEASE" (GENTRECAD)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,

"GENTRECAD builds on PROCARDIS, a large European integrated project designed to identify susceptibility genes for coronary artery disease (CAD). CAD has a complex multifactorial aetiology including a substantial heritable component. The current challenge addressed by GENTRECAD is to identify and characterise the genes and gene variants that are functionally implicated, as a basis for designing new ...
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 1

 TERMINÉ 

Prospective cohort studies of children with substantial medical diagnostic exposure (CHILD-MED-RAD)

Date du début: 1 sept. 2008, Date de fin: 30 nov. 2009,

The growing use of diagnostic X-rays and of high-dose techniques (CT, interventions) in children and adolescents is a topic of concern in radiological protection. Studies of other populations indicate that children are generally more sensitive to health effects of radiation than adults. In addition, children have a longer life-span to express any radiation-related health effect and, because of the ...
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 10