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13 projets européens trouvés

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 TERMINÉ 

The role of essential DNA metabolism genes in vertebrate chromosome replication (DNAMEREP)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"Faithful chromosomal DNA replication is essential to maintain genome stability. A number of DNA metabolism genes are involved at different levels in DNA replication. These factors are thought to facilitate the establishment of replication origins, assist the replication of chromatin regions with repetitive DNA, coordinate the repair of DNA molecules resulting from aberrant DNA replication events ...
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 1

 TERMINÉ 

A novel direct role of non coding RNA in DNA damage response activation (DDRNA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

DNA, if damaged, cannot be replaced. If not replaceable, it must be repaired. The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair. Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physi ...
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 1

 TERMINÉ 

Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease (CosmoPHOS-nano)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic thera ...
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 20

 TERMINÉ 

Vascular Endothelial interactionS and SpEciaLization (Vessel)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The vascular network plays essential roles in animal biology. Local disruption or impaired function of the vascular network is known to cause various pathological conditions, such as ischemic heart disease and stroke. The angiogenic growth of blood vessels is critically required during development, growth and regeneration, but it can also promote the growth of cancer cells and contribute to diabet ...
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 9

 TERMINÉ 

Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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 10

 TERMINÉ 

The role of Chronic DNA damage in Ageing and Age-related pathology (CodeAge)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothe ...
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 9

 TERMINÉ 

Transcriptional regulation of endothelial blood brain barrier differentiation by Wnt signaling (Wnt for brain)

Date du début: 1 août 2011, Date de fin: 31 juil. 2016,

The brain vasculature has evolved to protect the central nervous system from the constantly changing milieu in the blood stream. Endothelial cells of brain capillaries form the so called blood brain barrier (BBB), an active permeability barrier and transport system which allows a selective passage of nutrients from blood to the nervous tissue. The continuous cross talk of endothelial cells, pericy ...
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 1

 TERMINÉ 

THE ENDOCYTIC AND CYTOSKELETAL MATRIX IN THE PLASTICITY OF TUMOR CELL INVASION AND MIGRATION (The MetaEndoMatrix)

Date du début: 1 août 2011, Date de fin: 31 juil. 2016,

"Tumor cells can adopt different modes of cell motility. The ability to switch between diverse modes of migration enables tumors to adapt to micro-environmental conditions and to metastasize. The critical pathways and cellular processes underlying the plasticity of tumor cell motility have only begun to be identified.Endocytosis, originally thought of as a device to internalize nutrients and membr ...
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 1

 TERMINÉ 

Regulatory mechanisms coordinating replication integrity and intra-S repair (REPSUBREP)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

"The RecQ family of helicases, including BLM in human and its Saccharomyces cerevisiae homolog Sgs1, have important roles in maintaining genome stability. Sgs1 plays a specific role in response to intra-S DNA damage by resolving the pseudo double HJs resulting from replication-related sister chromatid junctions (SCJs). These catenated DNA structures are thought to represent template switch (TS) in ...
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 1

 TERMINÉ 

Blood-brain barrier junctions as targets for paracellular drug delivery to the brain (JUSTBRAIN)

Date du début: 1 nov. 2009, Date de fin: 30 avr. 2014,

"To maintain homeostasis of the central nervous system (CNS) the blood-brain barrier (BBB) prevents the free transcellular passage of hydrophilic molecules from the blood into the CNS. Because of this, the BBB is now recognised as the major obstacle to the treatment of most neurological disorders, as it hinders the delivery of many potentially important therapeutic and diagnostic substances to the ...
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 8

 TERMINÉ 

Molecular mechanisms of the regulation of mammary stem cell homeostasis and their subversion in cancer (MAMMASTEM)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

Stem cells (SCs) are thought to be integral to the development and progression of cancer, and their eradication may be essential for the cure of cancer. Yet, direct proof is lacking due to our poor understanding of the molecular differences between normal and cancer SCs. We will investigate normal and cancer mammary stem cells (MSCs) by focusing on the role of the cell fate determinant Numb in two ...
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 1

 TERMINÉ 

Mechanisms coordinating chromosome replication with transcription (REPTRA)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

"Genome stability during chromosome replication can be challenged by drugs affecting fork progression and intra-S DNA damage. While the mechanisms preserving the integrity of replicating chromosomes in response to replication stress induced by exogenous genotoxic events have been widely studied (Branzei and Foiani 2005; Branzei and Foiani 2007), those controlling fork stability under unperturbed c ...
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 1

 TERMINÉ 

Targeting of DNA deaminase AID via transcription and the RNA pol II elongation complex (AID Recruitment)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2013,

In B cells, antibody repertoire is created via two DNA instability complexes, one of which uses DNA cytosine deamination and is needed for immunoglobulin (Ig) diversification. Targeting of DNA deamination is poorly understood and mis-targeting can lead to genetic pathologies. Activation induced deaminase (AID) catalyses the hydrolytic deamination of cytosine residues, with the resulting uracil ind ...
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 1