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 TERMINÉ 

SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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 18

 TERMINÉ 

Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection (HIVACAR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planne ...
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 16

 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Neural circuit dynamics underlying expectation and their impact on the variability of perceptual choices (PRIORS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Just as our experience has its origin in our perceptions, our perceptions are fundamentally shaped by our experience. How does the brain build expectations from experience and how do expectations impact perception? In a Bayesian framework, expectations determine the environment’s prior probability, which combined with stimulus information, can yield optimal decisions. While the accumulation-to-bou ...
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 1

 TERMINÉ 

New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinase 3 (NEW DEAL)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Inflammatory bowel diseases (IBD) are the second most common immune-mediated disorders in Europe, affecting more particularly young people. The current therapies, including antibodies, show three main drawbacks: efficacy, tolerability and convenience. NEW DEAL solution will offer radical therapeutic progress for all IBD patients, thanks to the improved efficacy and increased safety of the specific ...
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 11

 TERMINÉ 

Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

 TERMINÉ 

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 TERMINÉ 

HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making (HarmonicSS)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along wi ...
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 39

 TERMINÉ 

Laser and Ultrasound Co-Analyzer for thyroid nodules (LUCA)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who are experts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards a concentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems (near-infrared diffuse correlation ...
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 8

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. (HEP-CAR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and be ...
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 9

 TERMINÉ 

Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes (T2DSystems)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Type 2 diabetes (T2D) is a major public health problem, affecting 55 million European citizens. T2D ensues in individuals who develop a progressive pancreatic beta cell failure. T2D probably comprises a heterogeneous group of diseases. A new molecular taxonomy of T2D is essential for the development of medical care that is predictive, preventive and personalized. Currently available T2D therapies ...
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 12

 TERMINÉ 

KONFIDO - Secure and Trusted Paradigm for Interoperable eHealth Services (KONFIDO)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

KONFIDO advances the state of the art of eHealth technology with respect to four key dimensions of digital security, namely: data preservation, data access and modification, data exchange, and interoperability and compliance. To address the challenges of secure storage and exchange of eHealth data, protection and control over personal data, and security of health related data gathered by mobile de ...
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 16

 TERMINÉ 

Clinical evaluation of carbons of controlled porosity as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease. (CARBALIVE)

Date du début: 1 mai 2015, Date de fin: 31 oct. 2019,

Chronic liver disease affects about 29-million Europeans accounting for about 170,000 deaths at a cost of around €15.8bn. This chronic non-communicable disease is increasing at an alarming rate due to increasing European obesity, alcohol use and ageing. The three main causes of the disease; alcohol, fatty liver and viral hepatitis are amenable to prevention and treatment. Gut-derived endotoxins an ...
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 15

 TERMINÉ 

Personalised Connected Care for Complex Chronic Patients (CONNECARE)

Date du début: 1 avr. 2016, Date de fin: 30 sept. 2019,

The ambition of the CONNECARE consortium is to co-design, develop, deploy, and evaluate a novel smart, adaptive integrated care system for chronic care management. This will save European healthcare organisations huge sums whilst improving patient outcomes. The consortium contains all the necessary partners to ensure success.Based on the concept of 4P medicine, CONNECARE will provide decision supp ...
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 10

 TERMINÉ 

Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance (RELEVANCE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

Anaemia is the most common pathological condition affecting 1.6 billion individuals worldwide. It thus presents a serious health care problem and an economic burden. Reduction in red blood cell (RBC) number can be caused by blood loss, diet, stress conditions including endurance sport, and pathologies which are caused by primary genetic aberrations or are secondary to the malfunction of other cell ...
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 13

 TERMINÉ 

Sustainable intEgrated care modeLs for multi-morbidity: delivery, FInancing and performancE (SELFIE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

Over 50 million people in Europe have more than one chronic disease. This number will increase dramatically in the near future. This will increase health care spending to a staggering 20% of GDP. Multi-morbidity becomes the number one threat to population health and economic sustainability of health care systems. New models of care for multi-morbid patients are urgently needed. Given the diversity ...
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 8

 TERMINÉ 

Characterizing Atrial fibrillation by Translating its Causes into Health Modifiers in the Elderly (CATCH ME)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a prevalence of 1.5-2% in European populations. By being a major cause of stroke, dementia, heart failure, and premature death, AF is a major threat to healthy ageing. Despite increasing knowledge on the diverse mechanisms that cause the AF substrate in individual patients, current strategies for prevention and therapy of AF rema ...
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 9

 TERMINÉ 

Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap (ARISE)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2019,

65,000 aortic valve replacements (AVR) are performed in Europe each year to treat acquired and congenital aortic valve diseases. In affected patients, mortality without AVR is extremely high and 50 % die within 2 years. Current AVR options are, however, limited for young patients - especially female patients - and those unwilling to accept life-long medical anticoagulation with its inherent risks. ...
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 9

 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

 TERMINÉ 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish (ZENCODE)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The recent explosion of next generation sequencing (NGS) data has caught Europe unprepared and led to a critical shortage of computational biology expertise. As NGS methods are expected to become pervasive from basic science to personalised medicine there is an urgent need for highly skilled young scientists trained in both computational biology and experimental wet lab biology. Our network addres ...
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 11

 TERMINÉ 

Does vascular endothelial growth factor gene therapy safely improve outcome in severe early-onset fetal growth restriction? (EVERREST)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

Fetal growth restriction (FGR) globally occurs in 8% of pregnancies, is severe and early onset in 1:500 cases, affecting 11,000 babies annually in the EU. In most cases, reduced uterine blood flow restricts substrate delivery to the fetus causing growth to slow or cease. There is no treatment. Currently the fetus is delivered very preterm before fetal death or irreversible organ damage occurs. Aff ...
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 10

 TERMINÉ 

Aetionomy – Organising Mechanistic Knowledge about Neurodegenerative Diseases for the Improvement of Drug Development and Therapy (AETIONOMY)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and (II) the focused application of this pipeline to derive clinically significant mechanistic taxonomies of neurodegenerativ ...
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 20

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

Combined Molecular Microscopy for Therapy and Personalized Medication in Rare Anaemias Treatments (CoMMiTMenT)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The aim of CoMMiTMenT is the development of combined imaging technologies based on optofluidic microscopy and scanning ion conductance microscopy. An integrated, completely simultaneous device named µCOSMOS will be used as a proof-of-principle for therapeutic interventions in rare anaemias. Both techniques rely on molecular detection: optofluidic microscopy relies on molecular biomarkers, and scan ...
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 9

 TERMINÉ 

A new therapeutic platform based on nanotechnology to promote T- and B-regulatory networks (NANOBreg)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2018,

The complexity of autoimmune responses is a barrier to the design of strategies that can selectively purge the immune system of autoreactivity without impairing systemic immunity. Recently, Santamaria et al. have shown that nanoparticles (NPs) coated with type 1 diabetes (T1D)-relevant peptide–MHC (pMHC) complexes can restore normoglycemia in diabetic animals by blunting the diabetogenic autoimmun ...
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 1

 TERMINÉ 

Graphene-based disruptive technologies (GrapheneCore1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS ...
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 158

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

Extracellular Vesicles and exosomes from adult stem cells in the regeneration of organ injury (EVESTEMINJURY)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages.The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs ca ...
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 5

 TERMINÉ 

Human monoclonal antibody therapy to prevent hepatitis C virus reinfection of liver transplants: advancing lead monoclonal antibodies into clinical trial (HepaMAb)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Worldwide, 200 million people are infected with the hepatitis C virus (HCV). An estimated 15 million individuals are living with HCV infection within the EU. The economic, health and societal costs of chronic HCV infection are significant. HCV is the principal cause of death from liver disease and the leading indication for liver transplantation. The only treatment for end-stage liver disease is a ...
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 7

 TERMINÉ 

Therapeutic TriMix / mRNA based Vaccine in Chronic HIV-1 Infected Patients Receiving Antiretroviral Therapy (IHIVARNA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

To find a therapy alternative to cART for life is one of the hot topics of investigation in HIV field. Therapeutic vaccination seems to be the best option. We have reported in a double-blind placebo controlled study some of the best, most solid data showing that HIV-1 specific immune responses elicited by therapeutic dendritic cell (DC) vaccines pulsed ex vivo with inactivated autologous whole vir ...
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 8

 TERMINÉ 

Contrast-enhanced uLtrasound for livEr-disease eValuation: development and validation of a novel E-Health-software for Risk-stratification (CLEVER)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"The CLEVER project is a 4-years training and transfer of knowledge program between a highly innovative company working in advanced biomedical image processing and two renowned academic groups working in the field of liver diseases and ultrasound research. The scientific and industrial aim of CLEVER is to develop, validate and transfer to clinical practice a novel electronic-health system based on ...
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 4

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Analysis of tridimensional changes caused by type 2 Diabetes-Associated varianTs (3D-ADAPT)

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

Despite the worldwide growing incidence of type-two diabetes (T2D), the molecular mechanisms are largely unknown. Genome Wide Association Studies (GWAS) have identified dozens of loci harbouring common SNPs that affect T2D susceptibility. The host lab recently showed that many associated SNPs lie in clusters of islet-specific regulatory elements that form tridimensional chromatin structures in the ...
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 1

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

 TERMINÉ 

Metabolic Impact of Dietary Protein Supplementation in Surgical Weight Loss (MIPS)

Date du début: 12 août 2013, Date de fin: 11 févr. 2017,

"Gastric bypass surgery (GBP) and vertical sleeve gastrectomy (VSG) result in 40% weight loss with normalization of metabolism in severely obese patients. Protein deficiencies have been described after bypass surgeries. Guidelines recommend protein supplementation after the surgery, but without evidence based data to support these recommendations. Dietary proteins have positive effects on energy h ...
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 1

 TERMINÉ 

Diagnosis of skin cancer using optics (DIAGNOPTICS)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,

DIAGNOPTICS deals with novel tools for the diagnosis and prognosis of skin cancer. Biophotonics-based tools for in-vivo and ex-vivo analysis of lesions will be combined in a pilot diagnostic workflow, which pursues using them as consecutive filters discarding benign lesions, and confirming the malignancy of others in order to guide them to surgery only when required. The in-vivo techniques will be ...
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 8