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Plus de 40 projets européens trouvés

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 TERMINÉ 

Conservation of the French populations of Galemys pyrenaicus and its populations on the French Pyrénées (LIFE+ DESMAN)

Date du début: 1 juin 2014, Date de fin: 31 mai 2020,

Background The Pyrenean desman (Galemys pyrenaicus) is a small semi-aquatic mammal that was discovered in 1811. Its distribution worldwide is restricted to the north-western Iberian Peninsula and the Pyrenean mountain range, a habitat that is seriously threatened by fragmentation. Since 2010, the DREAL Midi-Pyrénées in collaboration with the CEN MP has ...
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 7

 TERMINÉ 

Understanding evolutionary rates on the Tree of Life in time and space (ToLERates)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

According to models of adaptive radiation and sexual selection trait divergence is a key step in the speciation process. At a macroevolutionary scale this leads to the prediction that speciation is driven by the rate of trait evolution rather than the state of the trait. Despite the established theoretical links between trait evolution and speciation, most macroevolutionary studies focus on predic ...
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 1

 TERMINÉ 

Powering cells with light: the synthetic biology of photosynthesis (SYNTHPHOTO)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Billions of tonnes of chlorophylls are synthesised every year, then incorporated into the photosynthetic complexes that harvest and trap the solar energy that powers the biosphere. An understanding of the mechanisms that deliver chlorophylls to the growing photosynthetic apparatus is important for fundamental reasons, and also for future exploitation of photosynthesis as an energy source.The SYNTH ...
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 1

 TERMINÉ 

"Understanding the determinants of suicidal behaviour, serious accidents and violence in young people" (SAVYP)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Direct comparisons of risk factor profiles for different forms of self-destructive, hazardous and violent behaviour in young people have rarely been made in the same study cohort. This maintains a possibly erroneous assumption that these behaviours have distinct aetiologies. These outcomes may represent different aspects of the same complex underlying aetiology, rather than being disjunctive phen ...
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 2

 TERMINÉ 

Life in a cold climate: the adaptation of cereals to new environments and the establishment of agriculture in Europe (ADAPT)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"This project explores the concept of agricultural spread as analogous to enforced climate change and asks how cereals adapted to new environments when agriculture was introduced into Europe. Archaeologists have long recognized that the ecological pressures placed on crops would have had an impact on the spread and subsequent development of agriculture, but previously there has been no means of di ...
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 5

 TERMINÉ 

Ensuring the Integrity of the European food chain (FOODINTEGRITY)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Food Integrity “the state of being whole, entire, or undiminished or in perfect condition”.Providing assurance to consumers and other stakeholders about the safety, authenticity and quality of European food (integrity) is of prime importance in adding value to the European Agri-food economy. The integrity of European foods is under constant threat from fraudulently labelled imitations that try to ...
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 64

 TERMINÉ 

HiPERCAM: A high-speed camera for the study of rapid variability in the Universe (HiPERCAM)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

When stars die, they form white dwarfs, neutron stars or black holes. These are key objects in astrophysics as their extreme gravities, densities and pressures allow us to test our theories of fundamental physics at the limits of their predictive powers. One of the best ways of studying white dwarfs, neutron stars and black holes is via their variations in brightness. Unfortunately, due to the sma ...
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 3

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Labeling of Enalapril from Neonates up to Adolescents (LENA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Children are often treated as small adults—not as the special patients they are. Regulations exist to encourage the development of drugs and formulation for children. However, off-patent drugs are often administered to children without appropriate formulations or systematic investigations. Therefore, the paediatric use marketing authorisation (PUMA) has been designed.The EMA Paediatric Working Par ...
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 14

 TERMINÉ 

A “Universal” Influenza Vaccine through Synthetic, Dendritic Cell-Targeted, Self-Replicating RNA Vaccines (UniVax)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

 TERMINÉ 

EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 TERMINÉ 

Health and Environment-wide Associations based on Large population Surveys (HEALS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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 37

 TERMINÉ 

Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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 15

 TERMINÉ 

Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 

Climate Governance: Implementing public policies to calculate and reduce organisations' carbon footprint (LIFE Clim'Foot)

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Background The European Union has a set of objectives and policies to mitigate climate change and to shift towards a resource-efficient, low-carbon and climate-resilient economy. These objectives require the involvement of all European stakeholders with the support of national policymakers. The EU Emissions Trading System (ETS) has led to the development ...
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 7

 TERMINÉ 

Num@uvergne

Date du début: 1 sept. 2016, Date de fin: 31 août 2018,

This new project aims to make mobility one of the main strategies of our school development. The team that drives it and who is in charge of the preparation and organization process is now familiar with the mobility projects and is getting more and more accurate from a professional point of view, with the different actions conducted . The opening of a European class in September 2015 is a new guar ...
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 2

 TERMINÉ 

Carbon dioxide regulation of Earth’s ecological weathering engine: from microorganisms to ecosystems (CDREG)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

CDREG develops the major new Earth system science research hypothesis that tectonic-related variations in Earth’s atmospheric CO2 concentration ([CO2]a) drive negative ecological feedbacks on terrestrial silicate weathering rates that stabilise further [CO2]a change and regulate climate. This paradigm-changing hypothesis integrates ecological and abiotic controls on silicate weathering to underst ...
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 5

 TERMINÉ 

"The Economics of Cultural Transmission and Applications to Communities,Organizations and Markets" (TECTACOM)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"A central pillar of economic analysis is the assumption of exogenous preferences. This position however is specific to the discipline: other social sciences have always recognised that individuals may have endogenous preferences and values, influenced by the society in which they live. Recently however, there has been mounting evidence in the economic literature about the importance of cultural d ...
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 1

 TERMINÉ 

Definition and characterization of type I interferonopathies (T1-IFN)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

"Although the concept of grouping Mendelian disorders associated with an up-regulation of type I interferon (IFN) has not been previously recognised in the medical literature, my past and current work argues that this concept has scientific validity and clinical utility. I believe that such conditions, which include Aicardi-Goutières syndrome (AGS), spondyloenchondrodysplasia, and some cases of sy ...
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 2

 TERMINÉ 

Strategies to develop effective, innovative and practical approaches to protect major European fruit crops from pests and pathogens (Dropsa)

Date du début: 1 janv. 2014, Date de fin: 28 févr. 2018,

The DROPSA consortium will create new knowledge and understanding of the damage and losses of fruit crops resulting from pests and pathogens, with a specific focus on the new and emerging threats due to Drosophila suzukii and quarantine pathogens Pseudomonas syringae, Xanthomonas fragariae and X. arboricola. The project will deliver a cost effective approach that can be widely implemented by the E ...
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 27

 TERMINÉ 

Genetic High Throughput Screenings by random mutagenesis to identify Plasmodium falciparum critical genes for asexual growth, sexual differentiation and virulence affecting host immune responses (GeneticHTS reveal Pf)

Date du début: 1 févr. 2011, Date de fin: 21 févr. 2018,

Malaria is a global health problem that demands immediate practical actions to contain the high infection and mortality rates caused by Plasmodium species. Protective vaccine is still missing. Available drugs diminish their impact against Plasmodium as resistances are rising and expanding on the territories. While no vaccine of the current portfolio showed ideal protection and low-cost feasibility ...
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 2

 TERMINÉ 

MAGnetic Innovation in Catalysis (MAGIC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"The aim of the MAGIC Innovative Doctoral Programme is to train the future generation of leading investigators of biological catalysis/enzymology with a view to developing new enabling technologies that can advance physical understanding of catalysis and mechanism. Recent research has shown that enzyme catalysts exploit the coupling of motions to the reaction coordinate and employ classical and qu ...
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 1

 TERMINÉ 

Polymerisation-induced self-assembly (PISA)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The efficient, reproducible synthesis of bespoke organic nanoparticles of controlled size, morphology and surface functionality in concentrated solution is widely regarded to be a formidable technical challenge. However, recent advances by the Principal Investigator (PI) suggest that this important problem can be addressed by polymerisation-induced self-assembly (PISA) directly in aqueous solution ...
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 1

 TERMINÉ 

Pluripotent stem cell resources for mesodermal medicine (PLURIMES)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progeni ...
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 12

 TERMINÉ 

Exciton-Polaritons: New Physics and Long Term Applications (EXCIPOL)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

This proposal combines novel experimentation and physical insight with state-of-the-art advances in technology to establish the field of exciton-polariton physics in major new directions. The new physics takes advantage of unique polariton properties including very light mass, strong non-linearities, bosonic character and direct access to density, phase and quantum statistics. The major goals are: ...
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 1

 TERMINÉ 

Priming of plant immunity: from its onset to trans-generational maintenance (PRIME-A-PLANT)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Plant defence depends on speed: the sooner a plant recognises its attacker, the more effective its defence response will be. Over the course of evolution, plants have acquired the ability to prime their immune system after perception of specific environmental signals. This heightened state of defence enables a faster and/or stronger activation of inducible defence mechanisms after pathogen attack, ...
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 1

 TERMINÉ 

The analysis of mitochondrial dynamics in ageing and neurodegeneration (DYNAMITO)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The survival of our most active tissues, such as the brain and heart, throughout decades of a human lifespan presents an extraordinary biological challenge. Mitochondria are central to the life and death of these tissues. They provide the cellular energy required by these cells and protect them by buffering potentially lethal levels of cytoplasmic calcium, while at the same time mitochondria produ ...
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 2

 TERMINÉ 

Operational Potential of Ecosystem Research Applications (OPERAs)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Human use and exploitation of the biosphere is increasing at such a pace and scale that the sustainability of major ecosystems is threatened, and may not be able to continue to function in ways that are vital to the existence of humanity. Re-framing environmental resource use has led to the emergence of the concepts of ecosystem services (ES) and natural capital (NC). This discourse indicates not ...
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 27

 TERMINÉ 

Systems medicine of chronic inflammatory bowel disease (SYSMEDIBD)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillat ...
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 13

 TERMINÉ 

The biogenesis of tail-anchored membrane proteins: knowledge and exploitation (TAMPTING)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to creat ...
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 8

 TERMINÉ 

Bedside monitoring of infection based on exhaled breath (BreathDx)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Molecular analysis of exhaled breath is a new frontier in medical testing with an enormous potential for monitoring respiratory disease.Breath tests are non-invasive and require minimal patient effort. This makes them applicable in a wide range of settings varying from theintensive care unit (ICU) to home. Respiratory infections are the primary cause of death in ICU. More than half of the patients ...
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 4

 TERMINÉ 

EuroAprendiendo FP3

Date du début: 1 juin 2016, Date de fin: 30 sept. 2017,

The EuroAprendiendo FP3 Project encourages our students of Vocational Training to develope their Profesional Practices in Europe.GSD is a Cooperative Group since 1985 with over 15,000 students in the Community of Madrid. Within educational levels offered, becomes relevant in the last two years ( with the addition of the center of Buitrago ) the number of students of Medium and High Vocational Trai ...
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 7

 TERMINÉ 

DRIVING RE-INVESTMENT IN R&D AND RESPONSIBLE ANTIBIOTIC USE (DRIVE-AB)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2017,

Antimicrobial resistance (AMR) is widespread. Its global human and economic burden is tremendous and increasing annually. Yet today only a few pharmaceutical companies retain active antibacterial drug discovery programmes. While the elaboration of antibiotics with novel mechanisms of action is scientifically complex, the chief challenge is diminishing incentives. Pre-market regulatory requirements ...
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 27

 TERMINÉ 

Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PathChooser)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do ...
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 9

 TERMINÉ 

Methods for Integrated analysis of Multiple Omics datasets (MIMOmics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with nove ...
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 15

 TERMINÉ 

Sensing and integration of signals governing cell polarity and tropism in fungi (FUNGIBRAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"Cell polarity and directed growth (tropism) are fundamental biological processes. Most fungi are dependent on these processes because they grow as polarised filaments called hyphae, whose growth and developmentare governed by physical and chemical cues from the environment. Such cues include surface-contact, light, nutrients, mating partners, host organisms, or ‘self’ hyphae from within the fung ...
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 13

 TERMINÉ 

Distributed REal-Time Architecture for Mixed Criticality Systems (DREAMS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The objective of DREAMS is to develop a cross-domain architecture and design tools for networked complex systems where application subsystems of different criticality, executing on networked multi-core chips, are supported.DREAMS will deliver architectural concepts, meta-models, virtualization technologies, model-driven development methods, tools, adaptation strategies and validation, verification ...
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 16

 TERMINÉ 

Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington’s disease (Repair-HD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

This project will tackle the huge complexity of taking stem cell therapies to clinical application for neurodegenerative disease by focusing on selective differentiation of a single neuronal phenotype (medium spiny striatal neuron: MSN) for a single well-defined disease (Huntington’s: HD). Our consortium contains expertise in all elements required to drive this technology to the point of clinical ...
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 10

 TERMINÉ 

The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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 14

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53