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14 projets européens trouvés

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 TERMINÉ 

Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (Foie Gras)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of ...
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 11

 TERMINÉ 

Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia (TREATMENT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients ...
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 9

 TERMINÉ 

Advanced toolbox for rapid and cost-effective functional metagenomic screening - microbiology meets microfluidics. (METAFLUIDICS)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

Metagenomes comprise enormous reservoirs coding for proteins with useful activities. Unfortunately, harvesting this reservoir is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Screening campaigns of metagenomic libraries thus require massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and availab ...
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 14

 TERMINÉ 

Functional high-throughput analysis of the role of microRNAs in cardiac ischemia-reperfusion injury (microCardio)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2018,

Ischemia-reperfusion injury is a major cause of morbidity and mortality transversal to different clinical settings and pathologies, including myocardial infarction. Ischemia is characterised by insufficient supply of blood to tissues causing tissue oxygen deprivation. Importantly, damage by prolonged ischemia is further aggravated by reperfusion, leading to irreversible tissue damage. Identifying ...
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 1

 TERMINÉ 

Triggerable nanomaterials to modulate cell activity (NanoTrigger)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. F ...
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 1

 TERMINÉ 

CELLULAR AND SYNAPTIC DISSECTION OF THE NEURONAL CIRCUITS OF SOCIAL AND AUTISTIC BEHAVIOR (CELLSYNCIRCUITS)

Date du début: 1 août 2013, Date de fin: 31 juil. 2017,

"Synapses are the cellular specializations responsible for transducing information between neurons. Synaptic dysfunction is thought to underlie disorders such as schizophrenia, autism and mental retardation. Currently, a major challenge for modern neuroscience is to understand how synaptic computations give rise to behavioural and cognitive programs and identify how these same circuits are affecte ...
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 1

 TERMINÉ 

Mechanisms underlying hemogenic induction in human fibrobalsts (Inducing Hemogenesis)

Date du début: 18 févr. 2015, Date de fin: 17 févr. 2017,

Hematopoietic Stem Cell (HSC) transplantation whether from bone marrow, mobilized peripheral blood or cord blood is the best example of regenerative cell therapy. HSCs have remarkable therapeutic applications in a broad range of diseases that affect the blood forming and immune system. Nevertheless, there remains a shortage of usable genetically-matched material for all needs. Growing HSCs in vitr ...
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 1

 TERMINÉ 

Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion (CAFFEIN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Aim of the CAFFEIN network is to provide 10 early stage researchers (ESRs) and 2 exprerienced researchers (ERs) with excellent training in an industry relevant area of cancer research, complementary skills required for pharmaceutical industry, and knowledge in setting up biomedical start-up companies. To this end, the network comprises two full industrial partners: the established pharmaceutical ...
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 11

 TERMINÉ 

Novel nanoparticles for drug delivery to the skin (NANODRUG)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The aim of the NANODRUG Network is to contribute to the defragmentation of the emerging field of nanomedicine by providing a unique training programme that will cover all different aspects ranging from NP synthesis and characterisation, drug delivery, molecular biology to nanotoxicology, preclinical studies, risk assessment and nanotechnology policy making. The NANODRUG training program is far sup ...
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 9

 TERMINÉ 

TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases (TREATPOLYQ)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Protein aggregation is a hallmark of many late onset neurodegenerative disorders including Parkinson’s Disease (PD), Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), prion diseases as well as the group of polyglutamine diseases (polyQ). The aim of this proposal is to create a network of European partners bridging important basic mechanisms involved in proteinopathies, research of mod ...
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 17

 TERMINÉ 

The role of local mRNA translation in synapse formation (Presynaptogenesis)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

The objective of the proposed research is to identify the signaling mechanisms that lead to presynaptogenesis, the mechanism by which a functional presynaptic terminal is formed. Postsynaptic mechanisms such as LTF (long-term facilitation) in invertebrate neurons, and LTP (long-term potentiation) and LTD (long-term depression) in mammalian neurons have been well characterized and shown to be depen ...
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 1

 TERMINÉ 

Transplantation of magnetic-labelled vascular cells and cardiomyocytes isolated from human embryonic stem cells in a bioactive injectable gel for myocardium regeneration after infarct (HeartRegeneration)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2013,

Cardiovascular diseases remain the number one cause of death in the western world. Human embryonic stem cells (hESCs) represent a promising source of cells for the treatment of cardiovascular diseases because of their unlimited cell propagation and ability to give rise to different cell types, including cardiomyocytes, endothelial and smooth muscle cells. Cardiomyocytes isolated from hESCs have be ...
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 1

 TERMINÉ 

Role of Mitochondrial Physiology in Tumor Stem Cell Resistance to Chemotherapeutics (MitoCancerStem)

Date du début: 1 août 2010, Date de fin: 31 juil. 2012,

Although many advances in cancer research have heightened cases of long term survival, tumor re-growth is still a major concern. One hypothesis of the driving force behind tumor re-growth is the subpopulation of cancer stem cells found in varying types of tumors. Cancer stem cells have emerged as an important chemotherapeutic target over the past decade, as their ability to evade treatments provid ...
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 1

 TERMINÉ 

The role of reactive oxygen species in B cell tolerization and immune memory (BNOX)

Date du début: 1 juin 2009, Date de fin: 31 mai 2012,

"Chronic inflammation is a common feature in diseases like primary immunodeficiencies and autoimmunity. It is the consequence of the inability of the immune system to regulate and resolve the inflammatory process. Even though significant advances have been made in the past years to understand some of the mechanisms involved in chronic inflammation, which lead to the development of therapeutic stra ...
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 1