20 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
REgenerative therapy of intervertebral disc: a double blind phase 2b trial of intradiscal injection of mesenchymal stromal cells in degenerative disc disease of the lomber SPINE unresponsive to conventional therapy (RESPINE)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
...s. In addition, MRI T2 relaxation measurements demonstrated a significant improvement. To develop the world’s first rigorously proven, effective treatment of DDD, RESPINE aims to assess, via a multicentre, randomized, controlled, phase 2b clinical trial including 112 patients with DDD, the efficacy of an allogenic intervertebral mesenchymal stem cell (MSC)-based therapy. This innovative therapy ai ...
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18
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TERMINÉ
Are HPV vaccines ‘evolution-proof’? Multilevel evolutionary ecology of human oncoviruses (EVOLPROOF)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
There is a threat that evolutionary responses can render vaccines ineffective, as illustrated by the emergence of the increasingly virulent Marek Disease Virus strains in poultry following vaccination campaigns. Assessing the ‘evolution-proof’ nature of vaccines targeting human viruses is challenging because it requires an understanding of the epidemiology, the within-host ecology and the evolutio ...
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2
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TERMINÉ
Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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21
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TERMINÉ
THE MILESTONE PROJECT: Managing the Link and Strengthening Transition from Child to Adult Mental Health Care (MILESTONE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and socie ...
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14
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TERMINÉ
COMPACT BIOPHOTONIC PLATFORM FOR DRUG ALLERGY DIAGNOSIS (COBIOPHAD)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,
Drug hypersensitivity to antibiotics, mainly Beta-lactams (BLCs) affects more than 2.5 million European citizens. Moreover, preventable adverse drug reactions are estimated in additional hospitalization costs of 1750-4500 €/patient. Currently, the allergy diagnosis is mainly based on the information given by invasive, single, and risky in vivo assays. In daily practice, few in vitro diagnostic met ...
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11
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TERMINÉ
Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
...(ASCs) are attractive for cellular therapy given the abundance of tissue, high frequency of MSCs and minimally invasive harvest procedure. The EU consortium ADIPOA has shown in a ‘first in man’ 2-centre Phase I safety study that intraarticular injection of a single dose of autologous ASCs to the knee (18 patients, 12 month follow-up) was well-tolerated, had no adverse effects, and resulted in an i ...
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20
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TERMINÉ
I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly (I-MOVE-plus)
Date du début: 1 mai 2015, Date de fin: 31 oct. 2018,
The I-MOVE+ Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share val ...
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33
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TERMINÉ
Natural sensory feedback for phantom limb pain modulation and therapy (EPIONE)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
"Amputation of a limb may result from trauma or surgical intervention. The amputation traumatically alters the body image, but often leaves sensations that refer to the missing body part. In 50-80% amputees, neuropathic pain develops, also called phantom limb pain (PLP). Both peripheral and central nervous system factors have been implicated as determinants of PLP. Also, PLP may be triggered by ph ...
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13
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TERMINÉ
BeTheCuRE (BTCURE)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
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TERMINÉ
Clinical European study on the outcome of surgical and hormonal therapy and psychological intervention in disorders of sex development (DSD) (DSD-LIFE)
Date du début: 1 oct. 2012, Date de fin: 31 mars 2017,
Disorders of sex development (DSD) are a conglomerate of rare diseases with an estimated incidence of 1: 4500. The causes of DSD are mainly disorders with gonadal dysgenesis, decreased androgen synthesis or function in XY males or disorders with elevated androgen production in XX females. Decision on sex of rearing is difficult in some cases as the prenatal androgen imbalances result in ambiguous ...
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17
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TERMINÉ
A bioartificial pancreas to treat type 1 diabetes: optimization of cell survival and function in preclinical and clinical phases (BIOSID)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
MAILPAN (MAcroencapsulation of PANcreatic Islets) is a prototype of bioartificial pancreas usable in the human designed to treat type 1 diabetic patients. The prototype was developed along different stages since 1996 and led to the creation of the SME called Defymed in 2011. Next step is now to bring the prototype to the pre-clinical and clinical phases necessary to the ensuing commercialization o ...
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8
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TERMINÉ
Health and Wellness on the Beat (BEAT-HEALTH)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
There is a tight link between the rhythm of external information (e.g., auditory) and movement. It can be seen when we spontaneously or deliberately move on the beat of music (e.g., in dance), or when we enjoy performing physical and sport activities (e.g., running or cycling) together with music. This propensity to match movement to rhythm is natural, develops very precociously, and is likely har ...
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6
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TERMINÉ
Enhancing Social Interaction with an AlterEgo Artificial Agent (AlterEgo)
Date du début: 1 févr. 2013, Date de fin: 31 juil. 2016,
Description
AlterEgo: Humanoid robotics and Virtual Reality to improve social interactions
The objective of AlterEgo is the creation of an interactive cognitive architecture, implementable in various artificial agents, allowing a continuous interaction with patients suffering from social disorders ...
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7
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TERMINÉ
Suicidality: Treatment Occurring in Paediatrics (STOP)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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19
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TERMINÉ
Bringing the artificial pancreas home (AP@home)
Date du début: 1 févr. 2010, Date de fin: 31 oct. 2014,
Description
In order to improve treatment of diabetes patients at home, the main goal of AP@Home is to build and evaluate an artificial pancreas (AP). The AP will allow automated glucose control: It monitors your blood glucose (sugar) levels and a software algorithm calculates how much insulin to deliver at any time via a built-in insulin in ...
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15
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TERMINÉ
ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,
Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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12
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TERMINÉ
Personal Glucose Predictive Diabetes Advisor (DIAdvisor)
Date du début: 1 mars 2008, Date de fin: 30 juin 2012,
The DIAdvisor is a large scale integrating project (IP) aiming at development of a prediction based tool which uses past and easily available information to optimise the therapy of type I and developed type II diabetes.The DIAdvisor does not depend on specific sensor technologies and technologies like standard strip sensing, minimally-invasive continuous glucose sensors and non-invasive methods.Fo ...
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13
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TERMINÉ
Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics (Mitotarget)
Date du début: 1 févr. 2009, Date de fin: 31 mars 2012,
Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question re ...
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19
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TERMINÉ
Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers (EUROTRAPS)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2011,
The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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9
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TERMINÉ
The proposal aims at improving the quality and effectiveness of education and professional training of pharmacists by developing a set of standards of postgraduate education in Industrial and Clinical Pharmacy. To this effect, the project will develop an International postgraduate programme in Industrial and Clinical Pharmacy as well as an e-learning educational platform for continuous and profess ...
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