...cable dose adjustments during treatment and thus (iii) to improve efficacy while reducing risk of EDR or adverse effects.The MON4STRAT approach will be validated through a prospective, multicentre, randomized clinical trial with150 adults. Its applicability in paediatrics will be tested through an observational study with 70 children/neonates.Being generic in nature, MON4STRAT will be replicable t ...