8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A drug strategy targeting stabilised mutant p53 to fight metastatic platinum-resistant ovarian cancer (GANNET53)
Date du début: 1 oct. 2013, Date de fin: 31 mars 2019,
...otherapy versus standard chemotherapy alone in EOC patients with Pt-R Type II tumours. We established a highly efficient consortium with previously proven capability and manpower to perform this multicentre clinical trial and assess our innovative therapeutic concept in this deadly disease. Our consortium consists of national clinical trial groups in gynaecological oncology and high-volume Univers ...
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20
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TERMINÉ
EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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21
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TERMINÉ
Development of very promising humanized therapeutic mAbs efficiently neutralizing a novel immunosuppressive pathway involved in a wide range of cancers (TumAdoR)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Studies have demonstrated the importance of CD73 in the spread of cancer. Overexpressed in numerous cancer types, this enzyme leads to the production of high amounts of extracellular Adenosine, creating an immunosuppressive microenvironment, and contributing to tumor proliferation and dissemination. Neutralizing its activity represents a highly potent and innovative therapy.Following on the recent ...
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8
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TERMINÉ
First in Man Novel Anticancer Therapeutic based on Dependence Receptors Concept (HERMIONE-2MAN)
Date du début: 1 sept. 2013, Date de fin: 31 août 2016,
It is usually assumed that transmembrane receptors are inactive unless bound by their respective ligand. Against this dogma, the CLB proposed that some receptors may also be active in the absence of ligand and in this case trigger cell death. These receptors were called dependence receptors (DR) as their expression at the cell surface leads the cell to be dependent for its survival on ligand avail ...
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5
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TERMINÉ
EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS (ENCCA)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"ENCCA aims to establish a durable, European Virtual Institute clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This ...
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34
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TERMINÉ
Collaborative Oncological Gene-environment Study (COGS)
Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,
The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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16
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TERMINÉ
Developing and validating disease management evaluation methods for European health care systems (DISMEVAL)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
Chronic health conditions that impose a heavy burden on society and account for a large share of health care costs. Better prevention and management could potentially decrease costs and improve quality of care and health outcomes. An important means of accomplishing these goals is through the use of disease management (DM) interventions that educate patients about prevention and health management ...
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10
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TERMINÉ
Investigating a novel role of Notch3 as a dependence receptor and its relevance in vivo (NOTCH3DR)
Date du début: 1 juil. 2010, Date de fin: 31 août 2011,
"Cell survival depends on the integration of numerous signals provided by the extracellular environment. Activation of signal transduction by transmembrane receptors is assumed to occur following interaction with a specific ligand. However, some receptors, called dependence receptors (DRs) have been shown to mediate a signal in the absence of ligand. These receptors share the ability to mediate tw ...
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