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19 projets européens trouvés

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 TERMINÉ 

European stem cell consortium for neural cell replacement, reprogramming and functional brain repair (Neurostemcellrepair)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neurostemcellrepair aims at taking human stem cells through the final steps toward clinical application in cell replacement therapy for neurological disorders. PD will be taken as the prototypical disease because stem cell therapy is now close to clinical translation. Moreover, we will tackle next generation issues pertaining to stem cells at a basic level and develop new approaches and novel cell ...
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 13

 TERMINÉ 

Mechanisms of regulation of the blood-brain barrier; towards opening and closing the barrier on demand (BBBARRIER)

Date du début: 1 août 2012, Date de fin: 31 juil. 2017,

"In the bone-enclosed CNS, increased vascular permeability may cause life-threatening tissue swelling, and/or ischemia and inflammation which compromise tissue repair after trauma or stroke. The brain vasculature possesses several unique features collectively named the blood-brain barrier (BBB) in which passive permeability is almost completely abolished and replaced by a complex of specific trans ...
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 2

 TERMINÉ 

Role of chromatin-modifying enzymes in oligodendrocyte precursor state in development and multiple sclerosis (EPIOPC)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process which is defective in multiple sclerosis (MS). Although OL precursors can initially promote remyelination in MS, this process eventually fails. OL precursors (OPCs) go through several epigenetic states during development and MS, which ultimately define their potential to differentiate and myelinate. Transcription ...
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 1

 TERMINÉ 

NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies (NEURINOX)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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 15

 TERMINÉ 

Genetics and physiology of adolescent development in telencephalic interneurons (Adolescent Dev)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

To be developed
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 1

 TERMINÉ 

OSTEOIMMUNE - Unraveling the Interactions between the Immune System and Bone (OSTEOIMMUNE)

Date du début: 1 juin 2012, Date de fin: 31 mai 2016,

Inflammatory rheumatic diseases affect millions of European citizens causing chronic pain, disability and premature death. Curative treatments are lacking. Conventional research often focuses on one single organ system such as the bone or the immune system and. ignores interactions between organ systems. OSTEOIMMUNE is a supra-disciplinary training network that targets this gap by providing compre ...
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 12

 TERMINÉ 

GEnetic NEtworks as a tool for anti-CAncer Drug Development (GENECADD)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

Although several therapies target cellular pathways, current small molecules drug discovery is based on identification of inhibitors to single proteins, without knowledge of whether they are the most advantageous target. The objective of this proposal is to develop a novel method for drug discovery, combining phenotypic cell based screens with functional genetic networks to determine the molecular ...
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 2

 TERMINÉ 

Identification of genes important for human midbrain dopamine neuron development and Parkinson’s disease (DDPDGENES)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"The goal of this project is to determine whether the expression of developmental genes in defined subpopulations of DA neurons contributes to the specification of currently unrecognized midbrain DA neuron subtypes and whether their missexpression may contribute to the loss of DA neurons in the adulthood and to the pathogenesis of PD.Many developmental genes have been found to be implicated in the ...
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 5

 TERMINÉ 

Charting the landscape of brain development by large-scale single-cell transcriptomics and phylogenetic lineage reconstruction (BRAINCELL)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

Embryogenesis is the temporal unfolding of cellular processes: proliferation, migration, differentiation, morphogenesis, apoptosis and functional specialization. These processes are well understood in specific tissues, and for specific cell types. Nevertheless, our systematic knowledge of the types of cells present in the developing and adult animal, and about their functional and lineage relation ...
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 1

 TERMINÉ 

Nudix hydrolases in Cancer Therapy (NCAT)

Date du début: 12 août 2013, Date de fin: 11 août 2015,

Cancer is the activation of dysfunctional pathways leading to abnormal behaviour of cells. A hallmark of cancer is genomic instability, triggered by a range of DNA lesions such as 8-oxo-G, caused by reactive oxygen species (ROS). ROS are generated by the cell’s metabolism and are crucial for its homeostasis. However, excessive ROS levels can induce DNA lesions resulting in increased mutations, fue ...
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 1

 TERMINÉ 

Proof Of Concept Use of MTH1 Inhibitors as New Treatments for cancer (POCUMINT)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2015,

"In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used phenotypic screening and genetic networks to identify the DNA repair protein MTH1 as a critical component for cancer cell survival and we developed selective sub nM inhibitors to MTH1, which specifically kill cancer cells and tumours, whilst being less toxic to primary cells. Our approach provides a novel concept ...
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 2

 TERMINÉ 

Mechanisms of stem cell proliferation and senescence in the aged and damaged mouse brain (Aging stem cells)

Date du début: 1 janv. 2012, Date de fin: 12 nov. 2014,

Stem cell self-renewal is a consequence of the ability to proliferate indefinitely while maintaining pluripotency. In the adult brain, neural stem cells continuously produce neurons, and its importance for memory and repair after neurodegeneration and brain damage has been extensively investigated. However, adult neurogenesis is limited and significantly decreases throughout life. With aging, incr ...
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 1

 TERMINÉ 

Identification of a new mechanism of stem cell self-renewal; direct implications on self-repair and tumor initiating cells in the brain (STEMRENEWAL)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

"The self-renewing nature of stem cells is a consequence of their ability to proliferate indefinitely while maintaining pluripotency. Mechanisms of pluripotency are well known but mechanisms controlling stem cell proliferation are unknown. Proliferation of somatic cells takes place in G1 cell cycle phase. We have identified that embryonic and peripheral neural stem cell proliferation is regulated ...
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 1

 TERMINÉ 

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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 20

 TERMINÉ 

Neurobiological Mechanisms of Memory Loss in Alzheimer's Disease (MEMOLOAD)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2013,

"The MEMOLOAD project will focus on the molecular and biological mechanisms underlying memory loss that occurs in Alzheimer’s disease, the leading cause of dementia and an enormous medical, social and economic challenge to Europe. Several lines of evidence point to accumulation of beta-amyloid peptide (Aß) in the brain as the key pathologic event in the disease. There is growing evidence that ...
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 7

 TERMINÉ 

Novel strategies for the prevention and control of persistent infections (NOPERSIST)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

"Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infecte ...
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 12

 TERMINÉ 

"The identification, characterisation and exploitation of novel Gram-negative drug targets." (AEROPATH)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

"An ambitious long-term programme of multidisciplinary research with two closely linked objectives is proposed to support antimicrobial drug development. Firstly, to advance understanding, at the molecular level, of fundamental and important aspects of the biology of Gram-negative bacteria using the important pathogen model Pseudomonas aeruginosa. Secondly, and most important, to exploit our disco ...
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 5

 TERMINÉ 

EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS (EDICT)

Date du début: 1 févr. 2008, Date de fin: 30 juin 2012,

"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...
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 28

 TERMINÉ 

Defining the transcription factors code directing sensory lineage diversification and connectivity (sensory neurons code)

Date du début: 2 févr. 2009, Date de fin: 1 sept. 2010,

"How is the enormous cellular complexity that characterizes the vertebrate organism arising? Cell diversification depends on the coordinated deployment of multiple programs of cell commitment. One fundamental question is how a discrete number of transcriptional programs combine to produce different cell types. This research aims to address the principles of how cellular diversity is created in the ...
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 1