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16 projets européens trouvés

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 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Despite dramatic advances in molecular and imaging technologies, there are currently no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD). Major obstructions to this include a lack of aetiologically-driven or pathophysiologically-accurate animal models; an absence of tests that indicate efficacy; and reliance of clinical trials on DSM/ICD10 categories wh ...
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 29

 TERMINÉ 

European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity (EuroTARGET)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical ...
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 15

 TERMINÉ 

A European Initial Training Network on the History, Archaeology, and New Genetics of the Trans-Atlantic Slave Trade (EUROTAST)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The principal aim of this ITN is to examine the history of the transatlantic slave trade and its legacies from a variety of different angles. The idea is to hire thirteen Early Stage Researchers (ESRs) and two Experienced Researchers (ERs) across Europe and a wide range of disciplines, including history, archaeology, sociology, heritage studies and genetics, to investigate various aspects of the s ...
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 10

 TERMINÉ 

Pharmacogenomic biomarkers as clinical decision making tools for clozapine treatment of schizophrenia (CRESTAR)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Treatment resistant schizophrenia (TRS) is the most disabling of all psychiatric illnesses, affecting about 1/3 of patients (~1 million Europeans), a considerable economic and social burden. First-line treatments include atypical (e.g. olanzapine) and typical (e.g. haloperidol) antipsychotics. The original atypical, clozapine, is a final option, and although it is the only antipsychotic shown to b ...
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 11

 TERMINÉ 

Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
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 15

 TERMINÉ 

Aerodynamic Shape Optimization by Physics-Based Surrogates (ASOPBS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

"The main objective of the research project is to develop computationally efficient and robust procedures and algorithms for aerodynamic shape optimization using high-fidelity computational fluid dynamic (CFD) simulators that would go beyond the current state of the art and its limitations. The developed methodology will handle both two-dimensional and three dimensional aerodynamic/hydrodynamic su ...
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 1

 TERMINÉ 

Next generation disease mapping (NextGene)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2014,

During the last few years, most major disease phenotypes have been studied through genome-wide association mapping. This has been a remarkably successful enterprise, resulting in the discovery of more than 500 validated SNP-phenotype associations. Yet, these associations do not explain all the heritability of many common genetic diseases and it is not at all clear how they exert their effect at th ...
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 2

 TERMINÉ 

IAPP on novel genetic and phenotypic markers of Parkinson's disease and Essential Tremor (MarkMD)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2013,

Copy number variations (CNV) are ubiquitously found throughout in the human genome. Their role in monogenic as well as multifactorial disorders as potential disease modifier is more and more stressed (Abecasis et al., 2007). In order to investigate the role of CNV in Parkinson’s disease (PD) and Essential Tremor (ET), two frequent neurological diseases, MARKMD brings together the unique expertises ...
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 2

 TERMINÉ 

Comparative Genomics and Next Generation Sequencing (COGANGS)

Date du début: 1 nov. 2010, Date de fin: 28 févr. 2013,

"The activity of genes is absolutely essential for all life – from viruses and bacteria to crops and human beings. Despite the many technological breakthroughs within life science research during the last 20-30 years, we are however still far away from fully understanding the activity of genes and which factor influence (regulates) the gene activity. Such knowledge is, by nature, of very high impo ...
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 6

 TERMINÉ 

European Network for Genetic and Genomic Epidemiology (ENGAGE)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,

"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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 26

 TERMINÉ 

A comprehensive dissection of pneumococcal-host interactions (PNEUMOPATH)

Date du début: 1 mars 2009, Date de fin: 31 août 2012,

"This project is a fundamental, comprehensive study of the host-pathogen interactions during infection with Streptococcus pneumoniae. The expectation is that the basic knowledge gained from this work will give new targets for vaccination, diagnosis and treatment. In PNEUMOPATH, academic and industrial partners will work together in six scientific workpackages. 1) The molecular epidemiology of anti ...
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 15

 TERMINÉ 

Humanoids that Learn Socio-Communicative Skills by Observation (HUMANOBS)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

Description Developing new cognitive architectural principles to allow intelligent agents to learn socio-communicative skills by observing and imitating people Automatic imitation learning of socio-communicative skills is an interesting research topic with significant potential benefits for future ...
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 7

 TERMINÉ 

Copy number variations conferring risk of psychiatric disorders in children (PsychCNVs)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The recent technical improvements for the study of the cytogenetic basis of disease have led to the identification of many microdeletion and microduplication syndromes. De novo copy number variants (CNVs) are seen more often than expected in autistic patients, and rare chromosomal aberrations are known to account for a small fraction of schizophrenia and bipolar disorder. Recurrent spontaneous mut ...
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 8

 TERMINÉ 

Copy Number Variation and Endophenotypes in Psychiatric Disorders (PsychGene)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

A genome-wide copy number variant (CNV) association study for schizophrenia (SZ), bipolar disorder (BP) and major depression (MD) will be conducted at deCODE genetics using a discovery sample of 2400 affected (800 SZ, 600 BP, 1,000 MD) and 20,000 controls. CNV data will be generated from the newly released HumanCNV370-Duo array designed by deCODE genetics and Illumina. In this array there are abou ...
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 3

 TERMINÉ 

Identification and functional characterization of genetic cancer risk variants (CancerGene)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

This Industry-Academia Partnership and Pathways (IAPP) joins three groups which have hitherto focused on different aspects of cancer genetics. deCODE genetics (deCODE) has recently identified several genetic risk variants that are associated with increased risk of cancer, including two distinct genetic prostate cancer risk variants on chromosome 8q24. The University of Torino (UNITO) group has id ...
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 3