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Upscaling human insulin-producing beta cell production by efficient differentiation and expansion of endoderm progenitors (HumEn)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro. The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) gener ...
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