9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment (ESCAPE-NET)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
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17
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TERMINÉ
Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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25
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TERMINÉ
MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy (EPIMIRNA)
Date du début: 1 sept. 2013, Date de fin: 31 août 2018,
Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling p ...
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19
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TERMINÉ
Methods for Integrated analysis of Multiple Omics datasets (MIMOmics)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,
MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with nove ...
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15
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TERMINÉ
Dengue research Framework for Resisting Epidemics in Europe (DENFREE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
"WHO estimates that one of the main consequences of global warming will be an increased burden of vector-borne diseases. Among these, dengue appears to be particularly problematic, with tens of millions of cases of dengue fever estimated to occur annually, including up to 500,000 cases of the life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent years, the global burden of den ...
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15
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TERMINÉ
Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations (MEDIGENE)
Date du début: 1 janv. 2012, Date de fin: 31 juil. 2016,
MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and Nort ...
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22
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TERMINÉ
High Throughput Systematic Single Cell Genomics using Micro/Nano-Fluidic Chips for Extracting, Pre-analysing, Selecting and Preparing Sequence-ready DNA (CELL-O-MATIC)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
We propose a technology that will sit at the front-end of sequencing pipelines, present and future, and will significantly enhance the quality and throughput of DNA sequencing.Although much attention has been given to throughput/cost of the sequencing process itself, the same cannot be said for the preparation of samples. Identified bottlenecks are (1) sequencing technologies require days of upfro ...
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14
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TERMINÉ
SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2015,
Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
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27
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TERMINÉ
Genotype-To-Phenotype Databases: A Holistic Solution (GEN2PHEN)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,
"The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seaml ...
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