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25 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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 11

 TERMINÉ 

Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application (AFFINOMICS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

The Affinomics programme aims to leverage existing efforts in Europe to generate large-scale resources of validated protein-binding molecules (‘binders’) as affinity reagents for characterisation of the human proteome and to apply them in comprehensive structural and functional analyses of protein expression, interactions and complexes. Proteome targets will be focused on five categories of inter- ...
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 20

 TERMINÉ 

Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2015,

CHANCES aims at combining and integrating on-going cohort studies in order to produce evidence on ageing-related health characteristics and determinants in Europe, and their socio-economic implications. 15 cohorts participate, covering populations from 18 EU Member States, 4 associate countries, and 3 additional countries. The combination of these different studies would lead to an integrated appr ...
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 17

 TERMINÉ 

Target binders (TARGETBINDER)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

"We want to further develop our tools and technologies for high-throughput research, with the final goals being (I.) the particle-based combinatorial synthesis of 1 Mio different peptides on a glass slide for chemical costs of ~50€ (KIT, CBL, MS, TUV), and (II.) the labelling-free parallel readout of binding affinities by a variant reflectometric interference spectroscopy method for ~10.000 peptid ...
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 10

 TERMINÉ 

Augmenting PBGD expression in the liver as a Novel Gene therapy for Acute Intermittent Porphyria (AIPGENE)

Date du début: 1 janv. 2011, Date de fin: 31 oct. 2014,

Acute intermittent porphyria (AIP) is a rare genetic disease in which mutations in the porphobilinogen deaminase (PBGD) gene produce insufficient activity of a protein necessary for heme synthesis. This leads to an accumulation of toxic intermediates resulting in a wide variety of problems including acute, severe abdominal pains, psychiatric and neurological disorders, and muscular weakness. Acute ...
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 8

 TERMINÉ 

Collaborative Oncological Gene-environment Study (COGS)

Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

 TERMINÉ 

Selection and improving of fit-for-purpose sampling procedures for specific foods and risks (BASELINE)

Date du début: 1 août 2009, Date de fin: 30 nov. 2013,

"Food Safety Objectives (FSO) and Performance Objectives (PO) are new criteria complementing the existing concepts of microbiological criteria and MRL for many chemical contaminants. However, to achieve these objectives it is critically important a harmonisation of food safety control procedures.BASELINE project intends to obtain the following objectives: 1) To review the sampling schemes currentl ...
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 20

 TERMINÉ 

Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics (Predict-IV)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2013,

The overall aim of Predict-IV is to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in-silico modelling, in a rapid and cost effective manner. A better prediction of the safety of an investigational compound in early develo ...
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 20

 TERMINÉ 

Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
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 11

 TERMINÉ 

Persisting Transgenesis (PERSIST)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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 29

 TERMINÉ 

Three modality contrast imaging using multi-functionalized microballoons (3MICRON)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,

In vivo multimodality imaging is a fast growing field in medical research and, although the achievements at clinical level of this diagnostic method are recent, it is already one of the most promising approaches in the diagnosis of diseases in many research addressed medical centres. At present in this area, the USA plays the protagonist role as a result of the amount of resources engaged in the a ...
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 11

 TERMINÉ 

Natural Products and related Redox Catalysts: Basic Research and Applications in Medicine and Agriculture (Red Cat)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

Intracellular redox processes are pivotal for cell survival and proliferation. Redox active natural products, enzymes and their mimics may therefore be considered as regulators of various cellular processes which may, for instance, control inflammatory processes, cancer formation and proliferation, but also bacterial, fungal and microbial growth. It is now apparent that redox control exerted by su ...
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 10

 TERMINÉ 

Personalised and intergrated cardiac care: \nPatient-specific Cardiovascular Modelling and Simulation for In Silico Disease Understanding and Management (euHeart)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

Cardiovascular disease (CVD) has a significant impact on the European society in terms of mortality, morbidity and allied healthcare costs. The opportunity of multi-scale modelling spanning, sub-cellular level up to whole heart is to improve CVD outcomes by providing a consistent, biophysically-based framework for the integration of the huge amount of fragmented and inhomogeneous data currently av ...
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 21

 TERMINÉ 

Normalisation of immune reactivity in old age – from basic mechanisms to clinical application (TOLERAGE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2012,

"When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases ...
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 10

 TERMINÉ 

Development of carbohydrate array technology to systematically explore the functional role of glycans in healthy and diseased states (EuroGlycoArrays)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

The development and production of glycoarrays will provide the foreground knowledge necessary to lead to a step change in the diagnosis and treatment of diseases ranging from cancers to autoimmune diseases. Carbohydrates play a pivotal role in the molecular interactions that govern biological events at the centre of health and disease. This has become more evident as the characterisation and ident ...
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 17

 TERMINÉ 

European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Date du début: 1 mars 2008, Date de fin: 31 août 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

 TERMINÉ 

Distributed Dynamic Diversity Databases for Life (4D4Life)

Date du début: 1 mai 2009, Date de fin: 31 juil. 2012,

A coherent classification and species checklist of the world's plants, animals, fungi and microbes is fundamental for accessing information about biodiversity. The Catalogue of Life provides the world with a unique service: a dynamically updated global index of validated scientific names, synonyms and common names integrated within a single taxonomic hierarchy.The Catalogue of Life was initiated a ...
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 40

 TERMINÉ 

Advanced affinity tools and technologies for high throughput studies of the human proteome (AffinityProteome)

Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,

High specificity affinity reagents (‘binders’) are essential probes for proteome research, enabling the detection and localisation of multiple proteins in tissues and fluids in health and disease, through the application of binder-based technologies (affinity proteomics). This proposal links the high throughput production of quality-controlled, recombinant binding molecules of different types (ant ...
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 10

 TERMINÉ 

"Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine" (APO-SYS)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,

"A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apopto ...
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 24

 TERMINÉ 

Combinatorial synthesis of peptide arrays with a laser printer (PEPLASER)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,

"Our particle-based method allows us to synthesise high complexity peptide arrays by combinatorial synthesis and for an unrivalled prize. We plan to further develop this new technology up to the level of robust prototype machines, and mate it to bioinformatics and readout tools. Together, our procedure(s) should boost the field of proteomics in a similar way as the lithographic technologies did wi ...
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 12

 TERMINÉ 

Influence of oxidants on cell fate determination by use of a GFP coupled redox sensor (ROS in cell fate)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2011,

Reactive oxygen species are derivatives of aerobic metabolism. Their production is finely regulated to protect cells against severe and permanent damage to cellular components that could ultimately lead to programmed cell death. However at low levels, ROS act as second messagers in several signalling pathways leading to growth, differentiation, senescence or cell death. This dual function of ROS a ...
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 1

 TERMINÉ 

INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES (MITIN)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,

"A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for th ...
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 7

 TERMINÉ 

"Mathematical modelling of beta-catenin and ras signalling in liver and its impact on proliferation, tissue organization and formation of hepatocellular carcinomas" (CANCERSYS)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,

"The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with effects at the organ level will address the impact of these signalling networks on proliferation, tissue organization and form ...
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 10

 TERMINÉ 

Developmental Molecular Pathways in Drosophila as a Model for Human Cancer (CancerPathways)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,

Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution wi ...
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 8

 TERMINÉ 

The European Advanced Translational Research Infrastructure in Medicine (EATRIS)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

Efficient translation of research discoveries into industrial application is an essential element to maintain Europe’s competitiveness in the biomedical and health industry. The main bottleneck is the lack and the fragmented nature of essential research infrastructure and know-how, leading to unacceptable delays and/or preventing the development of new innovative medicines. The aim of EATRIS is to ...
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 20