7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
FRAGments training NETwork (FRAGNET)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
The promise of more efficient lead discovery is fuelling the enthusiasm for fragment-based lead discovery (FBLD). In this approach, highly sensitive biochemical and biophysical screening technologies are being used to detect the low affinity binding of low molecular weight compounds (the so-called fragments) to protein targets that are involved in pathophysiological processes. By investigating the ...
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9
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TERMINÉ
European Gram Negative Antibacterial Engine (ENABLE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,
The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a ...
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42
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TERMINÉ
Synaptic Systems: dissecting brain function in health and disease (SYNSYS)
Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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19
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TERMINÉ
Development of novel antiviral drugs against Influenza (FLUCURE)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2014,
"Influenza viruses cause a highly contagious respiratory disease in both humans and animals. Typically, influenza spreads worldwide in seasonal epidemics resulting in an estimated 3 to 5 million cases of severe illness and 250,000 to 500,000 deaths annually. In addition to these seasonal epidemics there have been several pandemics since the early 1900’s, where highly virulent strains emerged, the ...
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11
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TERMINÉ
BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
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14
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TERMINÉ
Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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24
Participants partenaires
TERMINÉ
Combating influenza using a novel drug strategy (FluDrugStrategy)
Date du début: 1 mars 2008, Date de fin: 31 août 2010,
Objective: To find and produce novel target compounds against the influenza virus. Influenza A capsid protein is the target since it does not mutate at the same rate as the Hemagglutinin or Neuraminidase proteins. We aim to develop new therapeutic antiviral solutions to combat the disease. Beyond state of the art: The project combines knowledge based design and synthesis of compounds with unique p ...
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