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Cell adhesion molecules (CAMs) mediate many critical processes in the mammalian brain, including formation and maturation of synapses. CAMs have been implicated in cognitive diseases, such as autism and schizophrenia, as candidate genes. These studies highlight the importance of understanding the mechanisms by which CAMs participate in normal and pathophysiological conditions. Synaptic adhesion-li ...

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...