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Signalling mechanisms of the class II isoforms of PI 3-kinase (PI3K-C2-SIG)
Date du début: 1 juin 2013, Date de fin: 31 mai 2015,
"PI 3-kinases (PI3Ks) generate intracellular lipid second messengers in signal transduction and membrane trafficking pathways. PI3Ks are implicated in cancer, inflammation and autoimmunity, and represent attractive drug targets. Mammalian PI3K isoforms are divided into class I, II and III PI3Ks. While the class I PI3Ks have been extensively studied and targeted in drug development, the other PI3Ks ...
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