2 projets européens trouvés
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TERMINÉ
Enzymatic and genomic targets of histone modifying enzymes and their role in liver metabolism and hepatocarcinogenesis (SET-NET)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
"In this proposal we will study the role of histone methytransferases Set9, PR-SET7, Smyd2, Smyd3 and the demethylase LSD1 in hepatocarcinogenesis and in the regulation of hepatic metabolic pathways.The hypothesis raised here suggests that the function of histone modifying enzymes is realized through 4 overlapping regulatory layers: i. via modifications of chromatin, ii. via modifications of recen ...
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TERMINÉ
Nuclear HuR-hnRNP interactions in post-transcriptional regulation of inflammatory gene expression (nRNPs & inflammation)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2013,
Inflammation, essential component of the innate immune response, allows multicellular organisms to repair damaged tissue. Excessive inflammation however, can itself exacerbate tissue damage, leading to chronic inflammation-related disease. The expression of crucial mediators of the inflammatory response is tightly regulated at transcriptional and post-transcriptional levels. Recent studies have sh ...
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