8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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43
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TERMINÉ
European Prevention of Alzheimer’s Dementia Consortium (EPAD)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,
Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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40
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TERMINÉ
PIVOTAL ASSESSMENT OF THE EFFECTS OF BIOACTIVES ON HEALTH AND WELLBEING. FROM HUMAN GENOMA TO FOOD INDUSTRY - PATHWAY (PATHWAY-27)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
Scientific understanding of the role and mechanisms of bioactives is fragmented. Research often addresses the theoretical possibility of health improvement effects rather than their real, practical use for everyday diets. Bioactives cannot be considered as discrete chemical compounds and research must focus on bioactive-enriched foods (BEF), if consumer demands for foods delivering appropriate hea ...
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28
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TERMINÉ
Scaffolds for alternative delivery (SADEL)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds.Existing Nf hits against validated targets will progre ...
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10
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TERMINÉ
Mucus Permeating Nanoparticulate Drug Delivery Systems (ALEXANDER)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,
The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, ...
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20
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TERMINÉ
Development of antibiofilm coatings for implants (COATIM)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, bu ...
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11
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TERMINÉ
Identifying correlates of protection to accelerate vaccine trials: systems evaluation of two models of experimentally-induced immunity to malaria (SysMalVac)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2014,
Vaccine development is an empirical process (trial and error) and involves a long, expensive clinical development pipeline to license an efficacious vaccine candidate. Better tools for vaccine evaluation are needed to adapt to a rising number of candidate vaccines entering clinical trials for many diseases. Surrogate biomarkers of immunity offer the possibility of expediting the clinical developme ...
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8
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TERMINÉ
Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)
Date du début: 1 sept. 2009, Date de fin: 28 févr. 2014,
Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
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