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22 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 TERMINÉ 

Setting an interdisciplinary/sectorial/international research network to explore dry storage as an alternative strategy for cells/germplasm biobanking (DRYNET)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

The number of biobanks for diagnostic/clinical/biodiversity preservation purposes is increasing exponentially, representing an economic burden for the EU. Cryopreservation (Liquid Nitrogen LN) is the only cells/gametes long-term repository method. LN storage is expensive though, requires dedicated facilities, is hazardous, carries pathogens and has high carbon footprint. DRYNET objective is to set ...
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 8

 TERMINÉ 

An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment (in3)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro a ...
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 14

 TERMINÉ 

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases (CaSR Biomedicine)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer ...
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 13

 TERMINÉ 

Patient-specific stem cell-derived models for Alzheimer’s disease and related neurodegenerative disorders (STEMMAD)

Date du début: 1 févr. 2013, Date de fin: 31 déc. 2017,

Future treatment of incurable neurodegenerative disorders, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), spinocerebellar ataxia (SCA), and Huntington’s disease (HD), has to be tailored to individual patients or cohorts of patients to obtain an optimal effect. The STEMMAD project is aimed to create a highly innovative international collaboration between 2 R&D intensive SME and ...
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 5

 TERMINÉ 

Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases (D-BOARD)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

"Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in jo ...
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 15

 TERMINÉ 

Next Generation Science Challenges Using Digital and Social Media to Make Science Education and Careers Attractive for Young People (SciChallenge)

Date du début: 1 sept. 2015, Date de fin: 31 août 2017,

Science education is tremendous in shaping the present and future of modern societies. Thus, the EU needs all its talents to increase creativity and competitiveness. Especially young boys and girls have to be engaged to pursue careers in Science, Technology, Engineering and Mathematics (STEM). However, statistics still show that enrolment rates in STEM-based degree programs are low and will lead t ...
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 9

 TERMINÉ 

Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type 1/2 (XENOISLET)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

During the last five years, within the EU FP6 Integrated Project XENOME (LSHB-CT-2006-037377), we have convincingly demonstrated in primates that a complete control of induced type 1 diabetes is routinely obtained for 6/8 months after transplantation of subcutaneous alginate macroencapsulated porcine islets xenograft without the use of any immunosuppression. In order to improve the function of pig ...
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 5

 TERMINÉ 

EpiHealthNet

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life.Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity fornewly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient deli ...
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 9

 TERMINÉ 

Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing (EpiHealth)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient de ...
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 7

 TERMINÉ 

"Induced pluripotent stem cells in rabbit, pig" (ANISTEM)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

"The ANISTEM project is aimed at creating a 4-years training and transfer of knowledge program between a Hungarian SME and a Dutch and a Hungarian University in the field of stem cell research in mammalians (rabbit, pig), which will open opportunities for a mutuallybeneficial long term partnership of veterinary and medical research and for applications between the industrial and academic participa ...
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 3

 TERMINÉ 

Effect of neuropeptides on selective neuronal differentiation of mouse embryonic stem cells (PepStem)

Date du début: 21 mai 2012, Date de fin: 20 mai 2015,

The capacity of embryonic stem cells (ES cells) to differentiate into neuronal cells represents a potential source for neuronal replacement and a model for studying factors controlling early stages of neuronal differentiation. Various molecules have been used to induce such differentiation but so far neuropeptides acting via G-protein coupled receptors have not yet been profoundly investigated. Si ...
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 1

 TERMINÉ 

High resolution tools to understand the functional role of protein intrinsic disorder (IDPBYNMR)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated ...
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 10

 TERMINÉ 

A IAPP on the Role of NCAM in Stem Cell Differentiation (STEMCAM)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMC ...
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 6

 TERMINÉ 

Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair (RESOLVE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"RESOLVE has been outlined to better understand the regulatory networks that control the devel-opmental processes in organ repair and to identify mechanisms which cause the termination of regu-lar organ development leading to fibroproliferative wound healing. Fibroproliferative wound healing represents a major pathology in elderly people shifting regular organ development into progressive organ fi ...
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 14

 TERMINÉ 

Improved gene transfer system to iPS cells in mouse (InduVir)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

The scientific aim of InduVir is to produce novel comparative information on the generation, maintenance and characteristics of iPS cells in mouse and on their differentiation towards different, especially cardiac lineages. In InduVir we are aiming to develop a novel system, by using removable transposons and polycistronic, deletable lentiviruses and therefore significantly reduce the risk of mali ...
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 1

 TERMINÉ 

Comparative Analysis of Rabbit and Mouse Pluripotency in Embryos and Stem Cells (RabPStem)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

The RabPStem proposal is aimed at increasing the fundamental knowledge of basic biological processes of cell pluripotency and differentiation by generating new comparative data on gene expression associated with cell pluripotency. RabPStem links for the first time research activities in a non-rodent (rabbit) and rodent (mouse) mammalian systems and in different cell types, from pluripotent cells i ...
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 1

 TERMINÉ 

NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE (NAD)

Date du début: 1 sept. 2008, Date de fin: 31 août 2013,

The search for effective therapies and early detection strategies for Alzheimer’s Disease (AD), the major cause of dementia in Europe, is imperative. It is known that β-amyloid (Aβ) peptide plays a central role in neurodegeneration. In AD brain, Aβ is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of Aβ are a hallmark of po ...
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 19

 TERMINÉ 

Induced pluripotent stem cells for cardiomyocyte generation in mouse (InduHeart)

Date du début: 16 mars 2009, Date de fin: 15 mars 2013,

The scientific aim of InduHeart is to produce novel comparative information on the generation, maintenance, characteristics of iPS cells in mouse and on their differentiation towards the cardiac lineage. InduHeart will also employ mouse embryonic stem (ES) cell lines to develop innovative methods for the targeted preparation of differentiated cardiac muscle cells. The characteristics of cardiomyoc ...
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 1

 TERMINÉ 

Comparative stem cell research in mouse and humans (INDUSTEM)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

The InduStem project is aimed at creating a mutually beneficial training and transfer of knowledge program between a Hungarian SME and a Dutch and a German academic research institution. The scientific and industrial aim is to generate novel information on the generation and maintenance of induced pluripotent stem (iPS) cells in mouse and human and on their differentiation towards cardiac cells. T ...
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 3

 TERMINÉ 

Comparative embryonic stem cell research in mammalians (PARTNERS)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

The PartnErS project is aimed at creating a mutually beneficial training and transfer of knowledge program between a Hungarian SME and a Danish and a Thai academic institution. The scientific and industrial aim is to generate new comparative information on the generation and maintenance of embryonic stem cells (ESCs) in mouse, pig and human and on their differentiation towards the neural lineage. ...
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 3

 TERMINÉ 

Systems biology approaches to understand cell pluripotency Acronym: PluriSys (PluriSys)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The PluriSys project is aimed at increasing the fundamental knowledge of basic biological processes of cell pluripotency and differentiation by generating new holistic data on gene expression and epigenetic modifications associated with cell pluripotency. The project integrates the multidisciplinary excellence in Europe in cell biology, molecular biology and bioinformatics. It also builds on earli ...
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 7