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10 projets européens trouvés

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 TERMINÉ 

Structural and mechanistic insights into RING E3-mediated ubiquitination (RINGE3)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Ubiquitin (Ub) conjugation regulates a myriad of cellular processes in the eukaryotic cell. Ub-ligases (E3) play a pivotal role in deciding the substrate’s fate and function by catalyzing the transfer of Ub from Ub-conjugating enzyme (E2) to a substrate protein lysine sidechain. Successive rounds of E3-catalyzed substrate ubiquitination lead to the formation of poly-Ub chains or multi-monoubiquiti ...
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 1

 TERMINÉ 

Metabolic functions of p53 in non-cancer pathologies (METABOp53)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

Extensive study of the p53 protein has resulted in a detailed understanding of its role in tumour suppression, information that is being used to develop small molecule modulators of p53 that are presently under evaluation for cancer therapy. However, it has recently become clear that p53 also plays roles in aspects of human health and disease extending beyond cancer - although most of these are po ...
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 1

 TERMINÉ 

SYSTEMS-BASED VIEW OF MELANOMA PROGRESSION: TOWARDS NOVEL DIAGNOSTIC (AND THERAPEUTIC) APPLICATIONS (SYS-MEL)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis a ...
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 7

 TERMINÉ 

Targeting downstream effectors of Wnt signaling in colorectal cancer (ColonCan)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Colorectal cancer (CRC) is one of the most common cancers of the western world. The underlying initiating mutation for the majority of CRC is within the Adenomatous Polyposis Coli (Apc) gene. The APC protein performs an important role in controlling the levels of Wnt signalling by targeting beta-catenin for degradation. Loss of the APC protein leads to the activation of Wnt signaling target genes ...
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 1

 TERMINÉ 

Characterization of Intestinal Cancer Cell Invasion (CICCI)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2017,

Approximately ninety percent of all cancer-related deaths are caused by the spread of cancer cells to distant sites rather than the growth of the primary tumour. The process of metastasis formation requires the ability of tumour cells to spread from primary tumours, by invasion of surrounding tissue, and afterwards by spreading to distant organs in order to manifest its devastating consequences fo ...
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 1

 TERMINÉ 

PRIMES: Protein interaction machines in oncogenic EGF receptor signalling (PRIMES)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

"PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit ...
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 14

 TERMINÉ 

Regulation of RNA polymerase III transcription by Id proteins and E47 (Id and Pol III)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The Id (Inhibitor of differentiation) family consists of four related transcription factors that are expressed at high levels in rapidly proliferating cells, including those found tumour cells. Overexpression of Id proteins in transgenic mice causes cancers. Ids have been shown to inhibit differentiation and promote cell proliferation in a variety of systems. This is achieved through interactions ...
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 2

 TERMINÉ 

The role of Chk1 in hair follicle stem cells and skin tumorigenesis (Chk1 in stem cells)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2012,

We have found that the ablation of Chk1, a serine-threonine kinase that is activated after DNA damage, strongly reduced the formation of chemically (DMBA/TPA) induced skin tumours, thus suggesting a role of this protein in hair follicle stem cells population, from which tumours are thought to arise. We have observed that deletion of Chk1 causes cell proliferation, DNA damage, and apoptosis within ...
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 1

 TERMINÉ 

Wnt Signalling in Colorectal Carcinogenesis and Intestinal Homeostasis (Wnt in the Intestine)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,

The intestinal epithelium is a highly self-renewing tissue, which is replenished by multipotent stem cells. Deregulation of normal intestinal homeostasis often results in malignant transformation. Colorectal carcinoma is one of the most common cancers in western world. Inactivating mutations of the Apc (Adenomatous Polyposis Coli) gene is key for colorectal cancer; up to 80% of sporadic colorectal ...
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 1

 TERMINÉ 

How biochemical networks encode biological specificity: Modulation of cell migration by isoform specific ERK and Akt signaling (BioSpec)

Date du début: 2 mars 2009, Date de fin: 1 mars 2011,

Understanding how biochemical signaling networks encode biological specificity is a fundamental challenge for biologists in the 21st century. Genome sequences by providing the “parts list” for such signaling networks, were expected to advance insight. However, it has become clear that to understand specificity analyzing only the “parts list” is not enough; it is the complex orchestration of these ...
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 2