12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
TRANSlating the role of Mitochondria in Tumorigenesis (TRANSMIT)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical eviden ...
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10
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TERMINÉ
Probing safety of nano-objects by defining immune responses of environmental organisms (PANDORA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, ...
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10
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TERMINÉ
Chromatin Dynamics in Development and Disease (Chromatin3D)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the ...
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12
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TERMINÉ
Cell-Based Models for Neurodegeneration Study and Use in Screening (CENSUS)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,
...g mature chemistry proprietary to Tissue Click Ltd (UK).8. Cell-based analysis products will be validated, and made user-friendly by in situ cell cryopreservation and analytical processes familiar to AvantiCell Science Ltd (UK).9. Each contributing technology is at TRL 6, and each has commercial utility in simpler combinations. The project assembles them in first-to-market formats beyond the curre ...
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4
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TERMINÉ
Additive Printing for Cell-Based Analysis (ANAPRINT)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2017,
The Project shall develop a unique manufacturing solution for the automated production of complex cell models widely used by industry to test biological activity and biosafety. No means of scalable manufacture presently exists. The technical solution is to assemble cell models by additive manufacturing; to control the resident cells’ locations within these 3D models; to supply the models to custom ...
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1
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TERMINÉ
Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers (PathChooser)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do ...
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9
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TERMINÉ
"Nano Engineering for Cross Tolerance: new approach for bioengineered, vascularised, chimeric islet transplantation in non-immunosuppressed hosts." (NEXT)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artifici ...
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6
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TERMINÉ
Cell-Based Models of Human Mucosal Immunity with Multiple Commercial Applications (HUMUNITY)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
...need of animal experimentation.Four trainees will experience an intersectoral training programme encompassing a 18-month internship in a UK SME expert in isolation and culture of human primary cells (AvantiCell Science), and 18 months in academic institutions (the Italian research organisation CNR, with secondments to the Universities of Pisa and Salzburg). Trainees enrolled in the PhD programme i ...
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2
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TERMINÉ
A bioartificial pancreas to treat type 1 diabetes: optimization of cell survival and function in preclinical and clinical phases (BIOSID)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
MAILPAN (MAcroencapsulation of PANcreatic Islets) is a prototype of bioartificial pancreas usable in the human designed to treat type 1 diabetic patients. The prototype was developed along different stages since 1996 and led to the creation of the SME called Defymed in 2011. Next step is now to bring the prototype to the pre-clinical and clinical phases necessary to the ensuing commercialization o ...
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8
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TERMINÉ
Additive Printing for Cell-based Analysis (ANAPRINT)
Date du début: 1 oct. 2014, Date de fin: 31 mars 2015,
The Project will develop and commercialise the additive printing of cell-based analysis systems. The objective is to deliver consistent, scalable manufacturing of cell-based models used by multiple industry sectors to evaluate materials ranging from new drugs to healthcare products and functional foods. The target market is global and growing (CAGR 12%; estimated $4.2Bn in 2016). Additive printing ...
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1
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TERMINÉ
Nanotechnology: Training Of Experts in Safety (NANOTOES)
Date du début: 1 nov. 2010, Date de fin: 28 févr. 2015,
Life Sciences and Nano Sciences interact today mainly in two areas: in the evaluation of accidental health and environmental effects derived from engineered nanomaterials, and in development and biological/clinical evaluation of nanoparticles with intended biological effects for application in medicine and biotechnology. It is essential for producers, distributors, consumers and regulators that th ...
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12
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TERMINÉ
Magnetic Scaffolds for in vivo Tissue Engineering (MAGISTER)
Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,
The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major ...
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