3 projets européens trouvés
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TERMINÉ
Cellular biology of virus infection (ViRNA)
Date du début: 1 févr. 2009, Date de fin: 31 janv. 2014,
...ased and systematic fashion, we will identify the critical host cell proteins needed by monitoring infection in human tissue culture cells after silencing individual genes using genome-wide siRNA libraries and large sub-libraries based on the human genome. The three viruses are vaccinia virus (a poxvirus), human papilloma virus 16, and Uukuniemi virus (a bunyavirus). They are members of importan ...
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1
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TERMINÉ
Molecular Mechanisms of Cell Entry of Enveloped Viruses (Virus Entry)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactio ...
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4
Participants partenaires
TERMINÉ
Cellular factors and pathways in the entry of Bunyaviridae (Bunyaviridae entry)
Date du début: 1 juin 2008, Date de fin: 31 mai 2010,
...factors involved in the attachment of Bunyaviridae at the cell surface and in the subsequent pathways taken by these viruses to enter cells and reach the cytoplasm. To achieve this goal, we will use various cell biology and molecular approaches, including light and electron microscopic methods and FACS techniques, combined with a large panel of perturbants of cellular entry pathways. To obtain a d ...
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