12 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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15
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TERMINÉ
Randomized controlled trial of metformin and dietary restriction to prevent age-related morbid events in people with metabolic syndrome (MeMeMe)
Date du début: 1 août 2013, Date de fin: 31 juil. 2018,
Age–related chronic diseases (ArCD) are complex non-linear processes that depends on a large number of interconnected genetic and metabolic pathways which should be tackled with a many faceted preventive strategy. Calorie-dense diet and sedentary lifestyle are responsible of the growing prevalence of metabolic syndrome (MetS), which, together with tobacco, is the major preventable cause of ArCD, m ...
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1
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TERMINÉ
Immunostimulatory Agonist antibodies for Cancer Therapy (IACT)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
"This concerted action aims at providing new treatment options for cancer patients through boosting innovative drug development by European academia and industry. A wealth of preclinical data shows that the therapeutic impact of cytotoxic regimens is enhanced by simultaneous application of drugs that strengthen the immune system. The recent FDA-approval of Ipilimumab demonstrated that cancer immun ...
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11
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TERMINÉ
Determinants of eating behaviour in European children, adolescents and their parents (I.Family)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
Nutrition-related diseases caused a loss of over 56 million years of healthy life of European citizens in 2000. I.Family will make a significant contribution to reduce this burden by studying the interplay and impact of the main drivers of dietary behaviour and food choice. It will take advantage of the unique opportunity to follow-up the large IDEFICS children’s cohort to not only provide added v ...
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17
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TERMINÉ
A European Platform for Translational Cancer Research (EUROCANPLATFORM)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,
Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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29
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TERMINÉ
Toward enhancing activities of European institutions in the FDUSCC-IM cancer research joint institute in China (IMMUNOCAN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"The joint institute Fudan University Shanghai Cancer Centre – Institut Mérieux laboratory (FDUSCC-IM), created in May 2010, is conducting ambitious scientific research projects on oncology in China. Its 2 founding partners, Fudan University (China) and Transgene (part of Institut Mérieux, France) wish to increase their translational medical research cooperation with European countries. In a firs ...
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5
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TERMINÉ
Determining (epi)genetic therapeutic signatures for improving lung cancer prognosis (CURELUNG)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,
"Lung cancer (LC) is still the most lethal type of cancer worldwide. The extremely poor prognosis for LC patients is partly due to the lack of effective therapies. At present, most patients with pulmonary carcinomas are treated with chemotherapy. This essentially consists of classic cytotoxic drugs which only improve survival in small cohorts in few cases. In spite of the rapidly growing understan ...
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11
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TERMINÉ
Genomic predictors and oncogenic drivers in hepatocellular carcinoma (HEPTROMIC)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2014,
"Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers, and is a major health problem. Its incidence is growing and with more than 700,000 annual cases worldwide -50,000 in Europe-, it is the 3rd cause of cancer-related mortality. Most patients are diagnosed at advanced stages with dismal survival rates lower than 1 year, even after sorafenib, the sole systemic therapy availab ...
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10
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TERMINÉ
Role and Modulation of Jak and STAT signaling in Graft Rejection and Graft versus Host Disease (HSCT and Jak-STAT)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,
Our interest is to extend the understanding of Jak and STAT signaling in the immunologic processes conditioning the outcome of allogeneic hematopoietic stem cell transplant (allo-HSCT) and to develop new strategies to overcome graft rejection (GR) and graft versus host disease (GVHD).Allo-HSCT is a potentially curative strategy for many patients. GR and GVHD hamper the success of allo-HSCT by con ...
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1
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TERMINÉ
Transfection Ability and Intracellular Pathway of LbL Nanostructured siRNA Delivery Systems (Nanosirna)
Date du début: 2 janv. 2011, Date de fin: 1 janv. 2014,
The scientific objective of the research carried out in this International Research Staff Exchange Scheme, is the development of a new technology to effectively deliver siRNA to cancer cells by the embedding of a polyplex into the multilayers and multifunctional nanocapsules. We propose to target pro-survival and anti-apoptotic factors in human cancer cells by using siRNA encapsulated into polyele ...
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3
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TERMINÉ
Three modality contrast imaging using multi-functionalized microballoons (3MICRON)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,
In vivo multimodality imaging is a fast growing field in medical research and, although the achievements at clinical level of this diagnostic method are recent, it is already one of the most promising approaches in the diagnosis of diseases in many research addressed medical centres. At present in this area, the USA plays the protagonist role as a result of the amount of resources engaged in the a ...
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11
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TERMINÉ
Standardisation and improvement of generic pre-analytical tools and procedures for in vitro diagnostics (SPIDIA)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,
"In vitro diagnostics have allowed a great deal of progress in medicine but are limited by two factors: (a) the lack of guidelines in collection, handling, stabilisation and storage of biosamples which limits the reproducibility of subsequent diagnoses, and (b) its scale is restrained to the cellular level. To address this first point, this IP, SPIDIA, built of clinicians, academics, tool and assa ...
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