8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Recombination in Adaptive Evolution (EvolRecombAdapt)
Date du début: 1 août 2014, Date de fin: 31 juil. 2019,
Meiotic recombination is a key source of genetic diversity with considerable implications for the genomic landscape and evolutionary process. By shuffling parental alleles to produce novel haplotypes, recombination impacts the strength of selection on nearby polymorphisms, and can increase the rate of adaptation in natural populations. Recombination defects can have serious phenotypic consequences ...
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TERMINÉ
NMR Spectroscopy of very large complexes: the atomic details of the mRNA degradation machinery (mRNA-decay)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
The cellular environment is extremely complex and contains thousands of different bio-molecules. To determine how these bio-molecules assemble into a highly organized molecular system has remained a major challenge. Here, we aim to unravel how dozens of proteins assemble into a large molecular machinery that degrades mRNA in an efficient and regulated manner.On an atomic level, we will determine t ...
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TERMINÉ
The Plant Immune System: Epistasis and Fitness-Tradeoffs (IMMUNEMESIS)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"A fundamental question in biology is how multicellular organisms distinguish self and non-self. The requirement to specifically recognize only foreign cells and molecules constrains the diversification of the immune system, resulting in conflicts between effective detection of enemies, adaptive changes in the cellular machinery and mating with divergent genotypes from the same species. In plants, ...
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TERMINÉ
analysis of postmitotic chromatin decondensation (CHROMDECON)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,
"Chromatin undergoes fascinating structural and functional changes during the metazoan cell cycle. It massively condenses at the beginning of mitosis with a degree of compaction up to fiftyfold higher than in interphase. At the end of mitosis, mitotic chromosomes decondense to re-establish their interphase chromatin structure. This process is indispensable for reinitiating transcription and trepli ...
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TERMINÉ
Towards a mechanistic understanding of mRNA localization (RNPlocalization)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The localization of mRNAs has been increasingly recognized as a prominent mode of regulation of gene expression in eukaryotes. Localized RNAs can have crucial roles during animal development, in the maintenance of cell polarity and in nervous system function. Studies of RNA localization in model organisms have revealed many components of the process, some of which are conserved across eukaryotes. ...
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TERMINÉ
Identity and functions of polyphosphate polymerases in eukaryotes (EUROPolYps)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Inorganic polyphosphate (polyP), a linear polymer of dozens to thousands of orthophosphate units, has been found in virtually every pro- and eukaryotic cell. PolyP regulates blood clotting, inflammation and bone formation in humans, symbiotic interactions in plants and stress responses in bacteria. The molecular functions of this high-energy polymer however remain largely enigmatic and its synthes ...
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2
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TERMINÉ
Multidisciplinary training in evo-devo and neurobiology of marine animal models (NEPTUNE)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
NEPTUNE will train a new generation of biologists through cutting edge research on marine animal models. The network unites 8 leading European labs with complementary expertise in evolutionary developmental biology (EvoDevo), bioinformatics, functional neurobiology, and palaeontology; four leading visiting researchers from Europe and the US; a full partner from industry, Sigma-Aldrich, specialised ...
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8
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TERMINÉ
Chromosome Packing in Plants (CPiP)
Date du début: 1 juin 2013, Date de fin: 31 mai 2015,
The three-dimensional organization of the genome in the nucleus is critical for many cellular processes. Hi-C is a newly developed, cutting edge method to analyze chromosome packing on a whole-genome scale using next-generation sequencing tools. Application of Hi-C to fungal and animal genomes has already revealed many new insights, providing a very high resolution picture of the nuclear arrangeme ...
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