4 projets européens trouvés
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TERMINÉ
Unravelling the immune signature of natural malaria transmission blocking immunity by protein microarray (SIGNAL)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
"Malaria continues to be the most important parasitic disease with as many as one million deaths annually. Despite these sobering figures, there is a decline in the burden of malaria that has stimulated researchers to set an agenda for worldwide malaria eradication. Malaria transmission blocking vaccines (MTBV) that induce antibody responses that prevent the transmission of malaria from man to mo ...
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1
Participant partenaire
TERMINÉ
Identifying correlates of protection to accelerate vaccine trials: systems evaluation of two models of experimentally-induced immunity to malaria (SysMalVac)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2014,
Vaccine development is an empirical process (trial and error) and involves a long, expensive clinical development pipeline to license an efficacious vaccine candidate. Better tools for vaccine evaluation are needed to adapt to a rising number of candidate vaccines entering clinical trials for many diseases. Surrogate biomarkers of immunity offer the possibility of expediting the clinical developme ...
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8
Participants partenaires
TERMINÉ
Clinical development of a Pfs48/45-based malaria transmission blocking vaccine (REDMAL)
Date du début: 1 mars 2010, Date de fin: 30 nov. 2014,
Malaria vaccines are needed to reduce the unacceptably high burden of disease and death in particular in the lowest income countries. Malaria vaccines aim at interruption of the life cycle of the parasite Plasmodium falciparum by induced immune responses in the humans. Transmission-blocking vaccines (TBMV) specifically aim at an arrest sexual stage development preventing the generation of infectio ...
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6
Participants partenaires
TERMINÉ
Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)
Date du début: 1 sept. 2009, Date de fin: 28 févr. 2014,
Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
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