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TERMINÉ
A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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TERMINÉ
Systematic Identification and Validation of Epigenetic Cancer Lesions by Chemical Biology and Functional Genomics (EPICAL)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,
Epigenetic pathways contribute to cancer development and progression. These pathways act via proteins that modulate chromatin structure and gene expression, and can thereby give pro-proliferative and anti-apoptotic properties selected for in cancer. In total ~400 factors are known that either modify chromatin directly as epigenetic ‘writers’ (DNA methyltranserases, histone methyltransferases, acet ...
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