9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Intelligent Assessment of Pharmaceutical in the Environment (IPIE)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Active pharmaceutical ingredients (APIs) can be released to the natural environment during the manufacturing process, following use by patients or when unused medicines are disposed of. As APIs are biologically active compounds concerns have been raised about the potential effects of APIs in the environment on human and environmental health. Over the past 15 years, a substantial amount of work has ...
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29
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TERMINÉ
Innate signaling networks in B cell antibody production: new targets for vaccine development (B-INNATE)
Date du début: 1 avr. 2012, Date de fin: 30 sept. 2017,
The long-term goal of this proposal is to explore a novel immune pathway that involves an unexpected interplay between marginal zone (MZ) B cells and neutrophils. MZ B cells are strategically positioned at the interface between the immune system and the circulation and rapidly produce protective antibodies to blood-borne pathogens through a T cell-independent pathway that remains poorly understood ...
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1
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TERMINÉ
Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities (ETOX)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2016,
The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This will be achieved by coordinating the efforts of specialists from academia and SMEs in the wide scope of disciplines that are required to move towards a more reliable modell ...
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30
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TERMINÉ
ASSESSMENT OF THE SAFETY OF LABAS IN ASTHMA IN ROUTINE CARE BY COMBINING HEALTH-CARE DATABASES AND DIRECT PATIENT FOLLOW-UP (ASTRO-LAB)
Date du début: 1 déc. 2011, Date de fin: 31 mai 2016,
Background: The efficacy of long-acting β-agonists (LABAs) in asthma has been demonstrated but their safety remains an issue, particularly in children. Co-therapy with inhaled corticosteroids (ICs) is recommended in persistent asthma. However, drug-use studies suggest frequently inadequate IC adherence, possibly explaining the occurrence of exacerbations. There is a need for detailed analyses of p ...
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9
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TERMINÉ
The Open Pharmacological Concepts Triple Store (OPEN PHACTS)
Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,
Drug discovery is data-hungry and all major pharmaceutical companies maintain extensive in-house instances of public data alongside internal. Analysis and hypothesis generation for drug-discovery projects requires assembly, overlay and comparison of data from many sources, requiring shared identifiers and common semantics. Expression profiles need to be overlaid with gene or pathway identifiers an ...
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32
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TERMINÉ
Uncovering the Role of Notch Modifiers in the Generation of Hematopoietic Stem Cells in the Embryo (FringEHE)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,
Hematopoietic Stem Cell (HSC)-based therapies are becoming a great expectation for the cure of several disorders that require HSCs for treatment. However, the incapacity to generate and maintain fully potent transplantable HSCs in vitro is still nowadays one of the main limitations for their wide application in cellular therapies. The study of the molecular mechanisms underlying HSC ontogeny in em ...
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1
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TERMINÉ
Arrhythmogenic potential of drugs (ARITMO)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,
The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
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21
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TERMINÉ
Improvement in Postoperative PAIN OUTcome (PAIN-OUT)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
The main objective of the proposed project is to develop and to validate a system for measurement and feedback of outcome quality and support of decision making. The project will be executed in the areas of postoperative pain management which serves as an example for other fields of medicine with a high variation of care. The project will provide the medical community with a unique, user-friendly ...
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18
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TERMINÉ
EuroDRG – Diagnosis-Related Groups in Europe: towards Efficiency and Quality (EuroDRG)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2011,
Payment systems are fundamental to any health care system, introducing powerful incentives and fierce technical design complexities. DRG-systems aim at fairly assessing the costs of patient treatment, taking into account measurable patient characteristics such as diagnosis or comorbidity – but to a varying degree also interventions chosen. Using a representative sample of inpatient data on 10-12 “ ...
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