8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type 1/2 (XENOISLET)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
During the last five years, within the EU FP6 Integrated Project XENOME (LSHB-CT-2006-037377), we have convincingly demonstrated in primates that a complete control of induced type 1 diabetes is routinely obtained for 6/8 months after transplantation of subcutaneous alginate macroencapsulated porcine islets xenograft without the use of any immunosuppression. In order to improve the function of pig ...
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5
Participants partenaires
TERMINÉ
EpiHealthNet
Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life.Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity fornewly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient deli ...
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9
Participants partenaires
TERMINÉ
Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing (EpiHealth)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient de ...
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7
Participants partenaires
TERMINÉ
High resolution tools to understand the functional role of protein intrinsic disorder (IDPBYNMR)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,
Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated ...
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10
Participants partenaires
TERMINÉ
A IAPP on the Role of NCAM in Stem Cell Differentiation (STEMCAM)
Date du début: 1 sept. 2010, Date de fin: 31 août 2014,
The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMC ...
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6
Participants partenaires
TERMINÉ
Improved gene transfer system to iPS cells in mouse (InduVir)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
The scientific aim of InduVir is to produce novel comparative information on the generation, maintenance and characteristics of iPS cells in mouse and on their differentiation towards different, especially cardiac lineages. In InduVir we are aiming to develop a novel system, by using removable transposons and polycistronic, deletable lentiviruses and therefore significantly reduce the risk of mali ...
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1
Participant partenaire
TERMINÉ
Comparative Analysis of Rabbit and Mouse Pluripotency in Embryos and Stem Cells (RabPStem)
Date du début: 1 sept. 2010, Date de fin: 31 août 2013,
The RabPStem proposal is aimed at increasing the fundamental knowledge of basic biological processes of cell pluripotency and differentiation by generating new comparative data on gene expression associated with cell pluripotency. RabPStem links for the first time research activities in a non-rodent (rabbit) and rodent (mouse) mammalian systems and in different cell types, from pluripotent cells i ...
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1
Participant partenaire
TERMINÉ
Induced pluripotent stem cells for cardiomyocyte generation in mouse (InduHeart)
Date du début: 16 mars 2009, Date de fin: 15 mars 2013,
The scientific aim of InduHeart is to produce novel comparative information on the generation, maintenance, characteristics of iPS cells in mouse and on their differentiation towards the cardiac lineage. InduHeart will also employ mouse embryonic stem (ES) cell lines to develop innovative methods for the targeted preparation of differentiated cardiac muscle cells. The characteristics of cardiomyoc ...
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