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Restoring Mueller glia cell – photoreceptor interactions with Crumbs (CRUMBS IN SIGHT)
Date du début: 1 avr. 2008, Date de fin: 31 mai 2012,
"Mutations in the Crumbs homologue 1 (CRB1) gene cause photoreceptor degeneration resulting in progressive retinitis pigmentosa (RP) or Leber congenital amaurosis (LCA), which both currently are untreatable blinding diseases. CRB1 is localized in Mueller glia cells at a subapical region (SAR) adjacent to adherens junctions between Mueller glia cells and photoreceptors. Loss of CRB1 function result ...
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