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24 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Understanding and exploiting complex glycan metabolism in the human microbiota (Human microbiota)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

The human large bowel is colonized by a community of microbes, the microbiota, which has a significant impact on human health and nutrition through the production of short chain fatty acids, and by interactions with the host immune system. The major nutrients available to these organisms are dietary glycans that are not metabolized by mammalian enzymes in the small intestines. Dietary and nutraceu ...
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 2

 TERMINÉ 

Reversibility and tissue specificity of mitochondrial translation defects in early childhood (reversibleCOX)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

We have recently identified the molecular genetic cause of a puzzling clinical syndrome, initially termed “benign infantile mitochondrial myopathy due to reversible cytochrome c oxidase (COX) deficiency”. While childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions with fatal outcome, this syndrome stands out by showing complete (or almost complet ...
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 1

 TERMINÉ 

Molecular basis of the outer membrane permeability (TRANSLOCATION)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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 28

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Universal Influenza Vaccines Secured (UNISEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

UNISEC brings together a European consortium of 3 University partners, 5 National Health Institutes and 3 SMEs, all with leading expertise in influenza vaccine research and development, to work on promising recently developed concepts for a universal influenza vaccine. The consortium is exceptionally strong, interdisciplinary and intersectional in nature, and encompasses a unique combination of sc ...
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 15

 TERMINÉ 

MOLECULAR BASIS OF ANTIBIOTIC TRANSLOCATION (Translocation)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Multidrug resistant bacteria are now ubiquitous in both hospitals and the larger community. Drug-resistant pathogens are becoming increasingly pervasive, for example, the resurrection of tuberculosis provides one ominous example highlighting the risk associated with evolved drug resistance. Moreover, many pharmaceutical companies abandoned this field and no truly novel active antibacterial compoun ...
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 11

 TERMINÉ 

Bacterial Persistence (PERSIST)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

"Almost all bacterial species generate persisters, individual cells that are tolerant to antibiotics. Persisters have entered a dormant or slow growing state in which they are recalcitrant to the killing activity of most known antibiotics. The molecular mechanisms underlying bacterial persistence are unknown and there is a pressing need to develop new methods and approaches to study the phenomenon ...
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 2

 TERMINÉ 

Life-like visual information processing for robust collision detection (LIVCODE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"To be able to detected collision efficiently is of vital importance for the survival of animals that are migrating at speed, especially for those flying in dense swarms like locusts. Vision plays a critical role in collision detection for most animal species in a dynamic world. It is expected that in future, many human made machines, such like ground vehicles, mobile robots, and unmanned aerial v ...
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 3

 TERMINÉ 

Advanced Training in Industrial Enzyme Manufacturing (ATRIEM)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"One of the main activities in the biotech industry is the manufacturing of enzymes, and access to cheap and diverse enzymes is crucial for the development of a sustainable biobased economy. However, improving the production efficiency of an increasingly large variety of commercial proteins and enzymes poses significant challenges for industrial-scale fermentations. In addition, the European biote ...
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 2

 TERMINÉ 

PERMETTRE LA MOBILITE DES JEUNES PAR UNE VALORISATION DES COMPETENCES ACQUISES GRACE AUX APPRENTISSAGES REALISES AU SEIN DE L’ESPACE EUROPEEN RENFORCER ET ENRICHIR LES PRATIQUES PROFESSIONNELLES DES EQUIPES ENGAGEES DANS UNE OUVERTURE A L'EUROPE

Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,

ALLOW THE YOUTH MOBILITY BY UPGRADING SKILLS ACQUIRED THROUGH LEARNING MADE WITHIN THE EUROPEAN SPACE The Regional Federation of MFR (FRMFR) in Brittany undertakes, in its mission of facilitating networks, eight MFR located throughout the Breton territory. The 161 young people involved in the Erasmus + program will go to twelve different countries: Switzerland, Ireland, Spain, Sweden, Poland, Port ...
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 165

 TERMINÉ 

Consortium for Products across Europe in Duchenne Muscular Dystrophy (SCOPE-DMD)

Date du début: 1 juin 2013, Date de fin: 31 mai 2016,

"This project builds on results from the TREAT-NMD and BIO-NMD European projects to develop a personalised-medicinal product through to market for the treatment of Duchenne Muscular Dystrophy (DMD). DMD is an inheritable, childhood rare disease that affects approximately 1 in 3,500 newborn boys. This rare disease is caused by mutations in the dystrophin gene, resulting in the absence or defect of ...
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 5

 TERMINÉ 

Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

 TERMINÉ 

The Plant Cell Wall Training Consortium (WallTraC)

Date du début: 1 juin 2011, Date de fin: 29 févr. 2016,

"Plant cell walls constitute a highly complex and dynamic entity of extreme importance in plant growth and development. Growing cell walls can be considered as ""fibre composites"", where cellulose microfibrils are embedded in a matrix of complex glycans. It is becoming increasingly apparent (i) that cell wall glycans are diverse in structural terms, (ii) that these structures are developmentally ...
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 11

 TERMINÉ 

Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

 TERMINÉ 

Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

 TERMINÉ 

Endoglin-Mediated Vascular Regeneration to Promote Heart Repair (VASC-GEN)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

"The standard emergency treatment for myocardial infarction (MI) has so improved over the last decade that most patients survive. However, many of these patients still go on to develop heart failure over the subsequent months and years. Vascular regeneration using autologous cells, if given at an early stage in patient treatment, can promote cardiac repair following MI and reduce the adverse card ...
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 1

 TERMINÉ 

Mechanisms of Transcription Proofreading (MTP)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2013,

Transcription, the copying of DNA into RNA, is the first step in the realisation of genetic information. RNA is either directly used by the cell or decoded into proteins during translation. The accuracy of transcription is thus essential for proper functioning of the cell. In all living organisms transcription is performed by multisubunit RNA polymerases, enzymes that are highly conserved in evolu ...
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 1

 TERMINÉ 

Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

 TERMINÉ 

Exploring the fundamental biology of microsporidian mitosomes (MICMIT)

Date du début: 2 mai 2011, Date de fin: 1 mai 2013,

"Microsporidia are tiny obligate intracellular parasites of other eukaryotes including patients with HIV/AIDS. Despite their importance, detailed knowledge of the biology of microsporidia is limited. Microsporidia were thought to lack mitochondria but the proposed host laboratory discovered, and have started to functionally characterise, highly reduced remnant mitochondria in these parasites, cal ...
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 1

 TERMINÉ 

Molecular biology of cell wall regeneration in L-form bacteria (Regenerate)

Date du début: 2 mai 2011, Date de fin: 1 mai 2013,

Cell wall deficient (L-form) bacteria are thought to be important in various resistant, persistent or chronic infections. L-form cells are highly abnormal in size and shape and are sensitive to osmotic shock but highly resistant to antibiotics that work on the cell wall (e.g. penicillins and cephalosporins). How these unusual cells arise and how they proliferate in the absence of a wall, is poorly ...
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 1

 TERMINÉ 

Gene- Environment Interactions in Heart Development (CHeartED)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM inci ...
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 11

 TERMINÉ 

Improving Plant Cell Walls for Use as a Renewable Industrial Feedstock (RENEWALL)

Date du début: 1 août 2008, Date de fin: 31 juil. 2012,

"With oil reserves diminishing and the effects of industrial emissions on global climate, there is a need for renewable carbon-neutral industrial feedstocks. First generation biorefineries, producing biofuels and bioplastics by the fermentation of sugar or starch, are seeing a rapid expansion and are adding stress to food supplies. A more sustainable option is to use plant biomass from agricultura ...
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 17

 TERMINÉ 

Pathophysiology and natural course of autoimmune adrenal failure in Europe (Euradrenal)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,

Autoimmune Addison’s disease (AAD) is an endocrine disease resulting from the immune system’s destruction of hormone producing cells in the adrenal cortex. Diagnosis is frequently first established after a life-threatening adrenal crisis, often resulting in untimely fatalities. The disease is rare, more common in women than in men, and also affects children. AAD very frequently occurs with other a ...
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 12

 TERMINÉ 

Reductive evolution of parasite genomes with a focus on the microsporidian Trachipleistophora hominis (TraHomGen)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,

Trachipleistophora hominis is a member of the microsporidia, a large group of obligate intracellular parasites of other eukaryotes including patients with HIV/AIDS. Microsporidia were originally thought to be early-branching eukaryotes lacking mitochondria. Recent data, key elements published by the proposed host laboratory, have now shown that they are highly reduced fungi with largely metabolica ...
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 1