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Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...

There is a high demand for patient specific cardiovascular disease therapeutics. Paediatric cardiology, in particular, faces difficult challenges due to the evolving nature of a child's heart and vascular system. Comprehensive and accurate computer models reconstructed from patient specific data and simulated physical constraints are needed to help determine better and more reliably risk stratific ...