7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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11
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TERMINÉ
New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,
Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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20
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TERMINÉ
Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function (ProProteinRegulation)
Date du début: 1 sept. 2012, Date de fin: 31 août 2016,
Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that ...
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2
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TERMINÉ
Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,
"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategie ...
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7
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TERMINÉ
"Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity" (NIMBL)
Date du début: 1 juin 2010, Date de fin: 30 nov. 2013,
"Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL condition ...
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10
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TERMINÉ
Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies (INFLA-CARE)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
Epidemiological and experimental evidence supports a link between chronic inflammation and cancer and indicates a role for inflammatory cells in the initiation, progression and metastasis of malignancy. The objective of the collaborative integrated project INFLA-CARE is to structure a European collective of scientific and technological excellence in the field of ‘Inflammation & Cancer’ which will ...
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22
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TERMINÉ
Analysis of the pathological implications of the abnormal accumulation of glycogen in specific cell types (MGS and disease)
Date du début: 1 juil. 2010, Date de fin: 13 juil. 2012,
Glucose is stored in specialized tissues (mainly liver and muscle) in the form of a branched polymer called glycogen. Glycogen Synthase is the only enzyme able to catalyze this polymerization and its two isoforms (LGS and MGS) are mainly expressed in liver and in muscle, respectively. However, MGS is also expressed in all other tissues, regardless of their limited capacity to produce Glycogen. MGS ...
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