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28 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
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 29

 TERMINÉ 

Towards zero road accidents - nature inspired hazard perception (HAZCEPT)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"The number of road traffic accident fatalities world wide has recently reached 1.3 million each year, with between 20 and 50 million injuries being caused by road accidents. In theory, all accidents can be avoided. Studies showed that more than 90% road accidents are caused by or related to human error. Developing an efficient system that can detect hazardous situations robustly is the key to red ...
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 3

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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 18

 TERMINÉ 

Mitochondrial European Educational Training (MEET)

Date du début: 14 janv. 2013, Date de fin: 13 janv. 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

 TERMINÉ 

Advanced Multidisciplinary Training in Molecular Bacteriology (AMBER)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"The advancement in life sciences has created a growing number of disciplines that are required to elucidate the increasingly complicated biological questions. This has led to an unsurpassed level of knowledge, but it has also resulted in a continuous specialization in PhD trainings, which makes the students less prepared for complex present day biological questions. To provide a better comprehens ...
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 9

 TERMINÉ 

Platform for sharing best practices for management of rare diseases (RARE-BESTPRACTICES)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

RARE-Bestpractices will develop a sustainable networking platform, supporting the collection of standardized and validated data and efficient exchange of knowledge and reliable information on rare diseases (RD).RD are characterized by low prevalence (EU – 5:10000 persons). There are more than 5000, overall affecting about 30 million citizens of all ages in the EU. RD are often life-threatening and ...
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 16

 TERMINÉ 

The role of Chronic DNA damage in Ageing and Age-related pathology (CodeAge)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothe ...
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 9

 TERMINÉ 

Retina-inspired ENcoding for advanced VISION tasks (RENVISION)

Date du début: 1 mars 2013, Date de fin: 31 août 2016,

The retina is a sophisticated distributed processing unit of the central nervous system encoding visual stimuli in a highly parallel, adaptive and computationally efficient way. Recent studies show that rather than being a simple spatiotemporal filter that encodes visual information, the retina performs sophisticated non-linear computations extracting specific spatio-temporal stimulus features in ...
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 4

 TERMINÉ 

A phase I/IIa clinical trial in Duchenne muscular dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,

Duchenne muscular dystrophy (DMD) is a progressive, lethal muscle degenerative condition arising from the absence of dystrophin in skeletal and cardiac muscles. 65% of DMD boys have out-of-frame deletions. Modulation of pre-mRNA splicing by exon skipping is the most promising molecular intervention in DMD. 2 Phase Ib and 2 Phase IIa clinical trials (MDEX Consortium in collaboration with Sarepta Th ...
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 10

 TERMINÉ 

Mucus Permeating Nanoparticulate Drug Delivery Systems (ALEXANDER)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, ...
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 20

 TERMINÉ 

"Extension, enhancement and strengthening of established collaborations for the purpose of a community-driven knowledge base for micronutrient genomics" (MICROGENNET)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"MICROGENNET is a collaboration of 16 distinguished universities and research institutes worldwide. The overall aim of the exchange programme is to build, extend and strengthen sustainable collaborations between the partners so as to create a community driven knowledge base for micronutrient genomics research. Currently, the data on nutrient effects on health are scattered in publications and da ...
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 9

 TERMINÉ 

Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium (PROTECT)

Date du début: 1 sept. 2009, Date de fin: 30 avr. 2015,

Recent pharmacovigilance (PV) issues have led to questions regarding the ability of the current PV system to meet the global needs. Controversies around the assessment of spontaneous reports and conflicting results from pharmacoepidemiology studies may lead to delay in, or inappropriate, regulatory decisions. The PROTECT consortium, consisting of 20 core partners lead by the European Medicines Age ...
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 36

 TERMINÉ 

Personalised nutrition: An integrated analysis of opportunities and challenges (Food4Me)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

The present proposal sees the development of business and value creation models as central to the development of personalised nutrition and thus it is intended to engage in a series of interviews with key stakeholders, which will generate a number of scenarios to be considered by these stakeholders. Parallel to that we will run some focus groups with consumers and develop a tool to ascertain consu ...
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 28

 TERMINÉ 

Tailored implementation for chronic diseases (TICD)

Date du début: 1 févr. 2011, Date de fin: 28 févr. 2015,

Project aim. Chronic diseases represent an important challenge facing healthcare systems. Research has consistently shown gaps between knowledge and practice for chronic illness care. Tailoring implementation interventions implies that the choice and content of implementation interventions are based on assessment of local barriers and enabling factors. It is widely believed that tailoring contribu ...
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 7

 TERMINÉ 

Symbiomics: Molecular Ecology and Evolution of Bacterial Symbionts (Symbiomics)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

Symbiosis research is currently in the midst of a revolution as molecular techniques are leading to major breakthroughs in our understanding of interactions between animals and microbes. There is an emerging recognition that all animals are intimately associated with a complex community of beneficial microbes that are essential for their development, nutrition, and health. Thus, modern symbiosis r ...
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 10

 TERMINÉ 

Optimizing delivery of health care interventions (ODHIN)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

ODHIN is a Europe wide project involving research institutions from nine European countries that will help to optimize the delivery of health care interventions by understanding how better to translate the results of clinical research into every day practice. ODHIN will use the implementation of identification and brief intervention (IBI) programmes for hazardous and harmful alcohol consumption (H ...
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 21

 TERMINÉ 

Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)

Date du début: 1 déc. 2010, Date de fin: 30 sept. 2014,

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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 10

 TERMINÉ 

Pharmaceutical Medicine Training Programme (PHARMATRAIN)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

"The proposed Pharmaceutical Medicine Training Programme provides a comprehensive solution for the complex needs of integrated drug development for all professionals involved, incl. physicians, pharmaceutical scientists,biologists, biometricians, health economists, and safety and regulatory scientists from universities, regulatory agencies, large, middle-sized and small pharmaceutical enterprises, ...
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 52

 TERMINÉ 

The evolution of gene content in parasitic protozoa (EVOGCPROTO)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

"Protozoan parasites from diverse evolutionary lineages including Trypanosoma and Leishmania, Giardia, Entamoeba, Plasmodium and the microsporidia have a major impact on human health, especially in developing countries and among immunocompromised individuals. During their evolution as parasites these organisms can both lose pathways if they can steal host metabolites and gain genes that may help t ...
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 1

 TERMINÉ 

Genomic & Epigenomic Complex Disease Epidemiology (GEoCoDE)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2014,

Genetic and epigenetic epidemiology are rapidly developing aspects of population-based health research that have clear translational potential. These endeavours both benefit considerably from extensive international collaborations. Establishing robust associations between genetic variation and common complex disease phenotypes requires very large sample sizes than can only realistically be generat ...
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 9

 TERMINÉ 

Prostate Research Organizations-Network of Early Stage Training (PRO-NEST)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) ...
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 18

 TERMINÉ 

RICHE – a platform and inventory for child health research in Europe (RICHE)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2013,

"The European Commission and other funding agencies make a large investment in child health research. The health of our children is satisfactory, but there are serious concerns, for example, obesity, mental health, alcohol abuse, and sexuality. We know that there are strong links between the health of young people and their social inclusion and level of education. Our objective is to establish a s ...
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 27

 TERMINÉ 

Arrhythmogenic potential of drugs (ARITMO)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
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 21

 TERMINÉ 

Fatty liver: Inhibition of Progression (FLIP)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

"Non-alcoholic fatty liver disease (NAFLD) has become one of the top concerns for the practising hepatogastroenterologist due to the obesity epidemic and its potential to progress to advanced liver disease which significantly impacts on overall and liver-related mortality. The aim of the FLIP (Fatty Liver: Inhibition of Progression) project is to understand and prevent the progression of liver dis ...
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 17

 TERMINÉ 

The impact of Regulation (EC) No 1394/2007 on the development of Advanced Therapy Medicinal Products (ATMPs): an academic perspective (Academic GMP)

Date du début: 1 sept. 2010, Date de fin: 31 mai 2013,

Advanced Therapy Medicinal Products (ATMPs) are medicinal products for human use, based on gene therapy, somatic cell therapy or tissue engineering. A rapidly growing area in translational research, they represent the ‘next generation’ of complex medicines for complex diseases and pose particular challenges to medicines regulation.Regulation (EC) No 1394/2007 has been designed to ensure the free m ...
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 9

 TERMINÉ 

Characterization of factors involved in proliferation of Bacillus subtilis L-forms (CFILP)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2012,

"The main objective of the project will be to characterize the molecular cell biology of proliferation in cell-wall deficient (L-form) derivatives of Bacillus. subtilis. L-forms can apparently arise from a wide range of bacteria and are often found in clinical situations. Recent work in the Errington lab has provided a highly tractable model system for studying the L-form state. B. subtilis L-form ...
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 1

 TERMINÉ 

Identifying and validating pre-clinical biomarkers for diagnostics and therapeutics of Neuromuscular Disorders (BIO-NMD)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2012,

"The rapidly expanding knowledge of NMDs genetic diagnosis, pathogenesis and therapeutic possibilities has provided new targets for disease characterisation, early diagnosis, drug discovery and development as well as has raised many questions about how to translate this knowledge into clinical practice as (initial) clinical trials typically run for such a short time that clinical improvement can h ...
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 15