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"Sequencing platforms in diagnostic laboratories may aid both patient management by detecting resistance associated mutations, and public health measures, by determining phylogenetic relationships between infections from different patients. Current platforms are limited by the timeframe required for generating a result and by the limited sequence information provided on pathogens. To overcome thes ...

Influenza A virus bears high morbidity and mortality burdens in humans following yearly seasonal epidemics and occasional yet potentially devastating pandemics. These burdens are a result of disease severity following infection in individual hosts, and the size of influenza epidemics/pandemics at the population level. The relationships and feedbacks between influenza virus pathogenesis at the indi ...