4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies (NEURINOX)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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15
Participants partenaires
TERMINÉ
The prion protein in health and disease (PRIONS)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,
Oligomers are toxic in an array of protein misfolding and aggregation (PMA) disorders. However, the chain of events from protein aggregation to dysfunction is poorly understood. Prion diseases are marked by accumulation of PrPSc, a misfolded variant of wild-type PrPC. PrPC mediates PrPSc neurotoxicity and counteracts toxic PrPC mutants, indicating that a subversion of normal PrPC function may unde ...
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1
Participant partenaire
TERMINÉ
Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,
"Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atyp ...
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21
Participants partenaires
TERMINÉ
Luminescent polymers for in vivo imaging of amyloid signatures (LUPAS)
Date du début: 1 nov. 2009, Date de fin: 31 déc. 2012,
"In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative metho ...
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