Plus de 40 projets européens trouvés
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TERMINÉ
SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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18
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TERMINÉ
European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment (ESCAPE-NET)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
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17
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TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis (CD40-INN)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Atherosclerosis, the underlying cause of the majority of cardiovascular diseases (CVD), is a lipid driven, inflammatory disease of the large arteries. Despite a 25% relative risk reduction achieved by lipid-lowering treatment, the vast majority of atherosclerosis-induced CVD risk remains unaddressed. Therefore, characterizing mediators of the inflammatory aspect of atherosclerosis is a widely rec ...
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1
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TERMINÉ
Skilled Intentionality for 'Higher' Embodied Cognition: Joining forces with a field of affordances in flux (AFFORDS-HIGHER)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
In many situations experts act adequately, yet without deliberation. Architects e.g, immediately sense opportunities offered by the site of a new project. One could label these manifestations of expert intuition as ‘higher-level’ cognition, but still these experts act unreflectively. The aim of my project is to develop the Skilled Intentionality Framework (SIF), a new conceptual framework for the ...
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1
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TERMINÉ
Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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19
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TERMINÉ
Multidisciplinary European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality (PRINT-AID)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
According to ECDC, over 4 million healthcare-associated infections in the EU cause 37,000 deaths and cost EUR 7 billion/year. Half of them are related to medical devices (i.e., catheters, implants) and 80% of these are related to bacterial biofilms. A recent EC report highlighted the medical device sector’s role in driving EU economic growth, employing 500k people in 25k companies (80% are SMEs) w ...
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8
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TERMINÉ
European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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43
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TERMINÉ
Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia (EU-GliaPhD)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,
The research in which the young scientists of the EU-GliaPhD consortium will be trained is centred on the role of neuron-glia interactions in brain function and pathology.Prompted by exciting discoveries of recent years, many academic research groups are currently focussing their research on the field of neuron-glia interactions for a better understanding of brain function. Also the private sector ...
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13
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TERMINÉ
European AIDS Vaccine Initiative 2020 (EAVI2020)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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27
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TERMINÉ
HIV-1 sensing and signaling in dendritic cells (SENTINEL)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,
HIV-1 is a major global health problem with over 2 million new infections every year, and although antiretroviral therapy is effective, chronic infected patients suffer from severe co-morbidities due to immune dysfunction. With the proposed SENTINEL project, I aim to identify novel strategies to enhance innate antiviral immunity to HIV-1 to limit establishment and progression of chronic disease. O ...
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1
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TERMINÉ
Stromal cells as primary drivers of immunopathology: towards targeted disease modification in spondyloarthritis (Inflammostrome)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Pro-inflammatory cytokines play a crucial role in chronic inflammatory diseases. Focusing on spondyloarthritis (SpA), a prevalent and debilitating rheumatic condition characterized by inflammation and abnormal new bone formation, we demonstrated that TNF and IL-23/IL-17 inhibition potently blocks inflammation. However, these treatments have no proven effect on pathologic new bone formation and the ...
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1
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TERMINÉ
PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS)
Date du début: 1 juin 2015, Date de fin: 31 mai 2020,
Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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20
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TERMINÉ
Coordination of regional dopamine release in the striatum during habit formation and compulsive behaviour (CoordinatedDopamine)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,
The basal ganglia consist of a set of neuroanatomical structures that participate in the representation and execution of action sequences. Dopamine neurotransmission in the striatum, the main input nucleus of the basal ganglia, is a fundamental mechanism involved in learning and regulation of such actions. The striatum has multiple functional units, where the limbic striatum is thought to mediate ...
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2
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TERMINÉ
Metabolic flexibility: breaking down food effectively to prolong life (MetaFlex)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2020,
Aging has long been considered a passive process. More recently studies have defined an important, active role for metabolic pathways in aging and age-related diseases. I have previously demonstrated a marked dysregulation of fat metabolism in aged mice that contributes to their overweight and glucose intolerance. Here, I propose a model that links healthy aging to efficient processing of nutrient ...
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1
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TERMINÉ
Molecular Subtype Specific Stem Cell Dynamics in Developing and Established Colorectal Cancers (CRCStemCellDynamics)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2020,
Annually 1.2 million new cases of colorectal cancer (CRC) are seen worldwide and over 50% of patients die of the disease making it a leading cause of cancer-related mortality. A crucial contributing factor to these disappointing figures is that CRC is a heterogeneous disease and tumours differ extensively in the clinical presentation and response to therapy. Recent unsupervised classification stud ...
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1
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TERMINÉ
Methods in Research on Research (MIROR)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
Our aim is to create, in Europe, an innovative and ambitious multidisciplinary intersectoral joint doctoral training programme, dedicated to Methods in Research on Research (MIROR) in the field of clinical research. “Research on Research”, is an emerging new scientific discipline that aims to reduce waste in research and increase research value. Waste in research represents tens of billions of Eur ...
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7
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TERMINÉ
European Sepsis Academy: towards new biomarkers to improve sepsis management (ESA -ITN)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) to determine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics for sepsis will be developed by buildin ...
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7
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TERMINÉ
Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)
Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,
Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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23
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TERMINÉ
Translating neuroimaging findings from research into clinical practice (PSYSCAN)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,
Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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24
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TERMINÉ
European Glaucoma Research Training Program-Plus (EGRET-Plus)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Glaucoma is the most common age-related neurodegenerative eye-disease in western society and one of the four major blinding eye diseases. If untreated or detected too late, glaucoma will end in blindness, yielding a profound loss of quality of life for the individual and major costs to society. Given the vast complexity of glaucoma, to advance assessment and therapy beyond the current state-of-the ...
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8
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TERMINÉ
Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes (iHealth-T2D)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,
South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinica ...
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13
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TERMINÉ
Targeting epigenetic REPROGRamming of innate immune cells in Atherosclerosis Management and other chronic inflammatory diseases (REPROGRAM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Up to 70% of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, considered to be in ...
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11
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TERMINÉ
COllaborative Management Platform for detection and Analyses of (Re-)emerging and foodborne outbreaks in Europe (COMPARE)
Date du début: 1 déc. 2014, Date de fin: 30 nov. 2019,
COMPARE aims to harness the rapid advances in molecular technology to improve identification and mitigation of emerging infectious diseases and foodborne outbreaks. To this purpose COMPARE will establish a “One serves all” analytical framework and data exchange platform that will allow real time analysis and interpretation of sequence-based pathogen data in combination with associated data (e.g. c ...
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32
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TERMINÉ
The making and breaking of ubiquitin chains in cholesterol metabolism (UNICOM)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
"Elevated levels of circulating LDL-cholesterol are a major determinant contributing to atherogenesis and coronary artery disease. Therefore, many studies address the central transcriptional pathways that regulate cholesterol metabolism. However, transcriptional regulation does not allow cells to quickly adapt to the cholesterol fluxes that they encounter. For this, rapid and reversible post-trans ...
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1
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TERMINÉ
Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging (DYNAHEALTH)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,
The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive fun ...
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14
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TERMINÉ
The roles of innate lymphoid cells and rhinovirus in asthma exacerbations (AsthmaVir)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
Asthma exacerbations represent a high unmet medical need in particular in young children. Human Rhinoviruses (HRV) are the main triggers of these exacerbations. Till now Th2 cells were considered the main initiating effector cell type in asthma in general and asthma exacerbations in particular. However, exaggerated Th2 cell activities alone do not explain all aspects of asthma and exacerbations. B ...
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1
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TERMINÉ
Challenging the gaps in global cancer concepts by a real life tumor: human childhood neuroblastoma (RealLifeCancer)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
The successes of cancer research stem from the identification of oncogenes and tumour suppressor genes and the study of their pathways in animal and cell line models. Confronting these models with ‘real life’ human cancer has often been a challenge. This grant aims at integral understanding of the aggressive childhood tumor neuroblastoma. Starting point is a huge database for this tumor. We establ ...
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1
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TERMINÉ
AN INNOVATIVE CAUSAL THERAPY FOR ALLERGY: SAFE AND RAPID INDUCTION OF AN ANTI-INFLAMMATORY IMMUNE RESPONSE USING A MUTANT HYPOALLERGEN AND VITAMIN D3 (BM4SIT)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Allergy is the most prevalent chronic inflammatory disease, having great socio-economic impact. Chronic lifelong dependency on symptomatic drugs is an expensive reality for the vast majority of allergy sufferers. Allergen-specific immunotherapy is the only causal and effective treatment targeting the underlying immune mechanism in a more cost-effective way. Yet, long treatment duration and risk of ...
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10
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TERMINÉ
Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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27
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TERMINÉ
The next generation epigenetic medicine for inflammation (EPIMAC)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Epigenetic mechanisms allow cells to adjust gene expression in response to environmental cues. Increased understanding of this area has led to excitement about the potential of applying epigenetic regulation to drug discovery. EPIMAC aims to pursue the potential of epigenetics as a novel and innovative therapeutic modality for immuno-inflammatory diseases, in particular Inflammatory Bowel Disease ...
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2
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TERMINÉ
Continuous Regional Analysis Device for neonate Lung (CRADL)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,
Each year 15 million babies are born prematurely and many suffer from respiratory failure due to immaturity of the lung and lack of control of breathing. Although respiratory support, especially mechanical ventilation, can improve their survival, it also causes severe injury to the vulnerable lung resulting in severe and chronic pulmonary morbidity lasting in to adulthood. Heterogeneity of lung ae ...
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11
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TERMINÉ
The Extracellular Matrix in Epileptogenesis (ECMED)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network ...
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10
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TERMINÉ
Multi-country cOllaborative project on the rOle of Diet, FOod-related behaviour, and Obesity in the prevention of Depression (MooDFOOD) (MOODFOOD)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
MooDFOOD is a Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression. Depression is one of the most prevalent, severe and disabling disorders in the EU and places a heavy burden on individuals and families. A large proportion of the EU population is overweight which increases depression risk. Improving food-related behaviour and ...
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17
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TERMINÉ
Functional optical probes for otology (FOIPO)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,
Various pathologies directly impede the conduction of sound through the human middle ear, and thereby produce a ‘conductive’ hearing loss which is the second most prevalent health issue globally. According to Hearing Health Foundation more than 360 million people suffer from hearing disorders worldwide. Hearing depends on a series of events that change sound waves in the air into electrical signal ...
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1
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TERMINÉ
Improving Metabolism via Prolonged Bile Acid Signalling targeting hepatic bile acid uptake to fight metabolic diseases (ProlongBileSignaling)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Bile acids play a pivotal role in energy supply as they facilitate the solubilization and absorption of fat in the intestine. Furthermore, bile acids are recently identified as important signalling molecules regulating glucose metabolism, inflammation and energy expenditure. Targeting bile acid signalling is, therefore, appealing to treat metabolic diseases such as diabetes and atherosclerosis. Th ...
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1
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TERMINÉ
Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe (ANTIDotE)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against ...
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8
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TERMINÉ
Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior (MyNewGut)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Emerging evidence indicates that the gut microbiome contributes to our ability to extract energy from the diet and influences development and function of the immune, endocrine and nervous systems, which regulate energy balance and behaviour. This has led to hypothesize that developing microbiome-based dietary interventions can be cost-effective measures to prevent diet-related and behavioural diso ...
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30
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TERMINÉ
Targets and biomarkers for antiepileptogenesis (EPITARGET)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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20
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TERMINÉ
Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex (EPISTOP)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usual ...
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