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12 projets européens trouvés

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 TERMINÉ 

SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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 18

 TERMINÉ 

Children’s Liver Tumour European Research Network (ChiLTERN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying ...
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 21

 TERMINÉ 

Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap (ARISE)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2019,

65,000 aortic valve replacements (AVR) are performed in Europe each year to treat acquired and congenital aortic valve diseases. In affected patients, mortality without AVR is extremely high and 50 % die within 2 years. Current AVR options are, however, limited for young patients - especially female patients - and those unwilling to accept life-long medical anticoagulation with its inherent risks. ...
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 9

 TERMINÉ 

Defining the role of xeno-directed and autoimmune events in patients receiving animal-derived bioprosthetic heart valves (TRANSLINK)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a ...
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 14

 TERMINÉ 

Global Research in Paediatrics (GRiP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

 TERMINÉ 

European clinical study for the application of regenerative heart valves (ESPOIR)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

Acquired and congenital heart disease can necessitate heart valve replacement. However, current heart valve substitutes are not considered ideal as they need anticoagulation, bearing the risk of bleeding when manufactured from non-organic material, or they degenerate when they derive from animals or human tissue donators (homografts) thereby leading to frequent reoperation especially in the young ...
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 15

 TERMINÉ 

DEferiprone Evaluation in Paediatrics (DEEP)

Date du début: 1 janv. 2011, Date de fin: 31 août 2016,

"β-thalassaemia major is one of the most severe forms of chronic congenital anaemia. The recommended treatment consists in regular blood transfusions combined with chelating therapy to remove harmful iron accumulation in the body. The use of deferoxamine, the first chelating agent only available for subcutaneous administration is limited due to toxicity and the lack of compliance, despite its sat ...
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 18

 TERMINÉ 

Surgery network on extended cross-border areas (E-SURGERYNET)

Date du début: 30 sept. 2011, Date de fin: 30 mai 2014,

The project anticipate the creation of cross-border network of surgical excellence in order to establish the clinical and organizational models of surgical intervention and management. Expected Results: Common technology platf ...
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 10

 TERMINÉ 

European Paediatric Oncology Off-Patent Medicines Consortium (EPOC)

Date du début: 1 févr. 2009, Date de fin: 31 oct. 2013,

Cancer chemotherapy has a key role in the successful treatment of a number of childhood cancers. Nevertheless, at least 20% of patients are not cured by current therapies and a significant number experience debilitating toxicities. Given the high cure rates and potential life-span of survivors of childhood cancer, it is particularly important to minimize the impact of potential chronic toxicities. ...
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 11

 TERMINÉ 

Patient Centric Approach for an Integrated, Adaptive, Context Aware Remote Diagnosis and Management of Cardiovascular Diseases (BRAVEHEALTH)

Date du début: 1 mars 2010, Date de fin: 31 juil. 2012,

BRAVEHEALTH proposes a patient-centric vision to CVD management and treatment, providing people already diagnosed as subjects at risk with a sound solution for continuous and remote monitoring and real time prevention of malignant events. The solution proposed will be made up of the following sub-systems: 1)WEARABLE UNIT: it is an innovative concept of miniaturised multi-parameter sensor, able to ...
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 18

 TERMINÉ 

Safety Of non-Steroidal anti-inflammatory drugs (SOS)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2012,

"The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs). The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD an ...
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 11

 TERMINÉ 

Relating Expectations and needs to Participation and Empowerment of children in Clinical Trials (RESPECT)

Date du début: 1 juin 2008, Date de fin: 31 août 2011,

"There are two objectives for this project, firstly to clarify the expectations and needs of children and their families who have participated or who might participate in clinical trials for new drugs in Europe. Secondly, to identify methods by which the expectations and needs can be translated into empowering and motivating participants in future clinical trails research. This will be achieved in ...
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 7