3 projets européens trouvés
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TERMINÉ
Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongl ...
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12
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TERMINÉ
Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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10
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TERMINÉ
The role of Chronic DNA damage in Ageing and Age-related pathology (CodeAge)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothe ...
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