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 TERMINÉ 

Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling (ChromatinRemodelling)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,

The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure and their aberrant regulation or dysfunction has been implicated in various cancers and severe developmental disorders. A better understanding of the roles of chromatin-interacting complexes i...
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 1

 TERMINÉ 

Chemistry and Biology in Synergy - Studies of hydrogenases using a combination of synthetic chemistry and biological tools (CaBiS)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

My proposal aims to take advantage of my ground-breaking finding that it is possible to mature, or activate, the [FeFe] hydrogenase enzyme (HydA) using synthetic mimics of its catalytic [2Fe] cofactor. (Berggren et al, Nature, 2013) We will now explore the chemistry and (bio-)technological potential of the enzyme using an interdisciplinary approach ranging from in vivo biochemical studies all the ...
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 1

 TERMINÉ 

The Violence Early-Warning System: Building a Scientific Foundation for Conflict Forecasting (ViEWS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The challenges of preventing, mitigating, and adapting to large-scale political violence are daunting, particularly when violence escalates where it is not expected. Early-warning systems of sufficient quality and transparency do not exist, limiting the ability of the international community to effectively assist affected populations. We propose to develop, test, and iteratively improve a pilot Vi...
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 1

 TERMINÉ 

Fundamental and Applied Science on Molecular Redox-Catalysts of Energy Relevance in Metal-Organic Frameworks (MOFcat)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Organometallic redox-catalysts of energy relevance, i.e. water and hydrogen oxidation, and proton and carbon dioxide reduction catalysts, will be incorporated into metal-organic frameworks (MOFs). Immobilization and spatial organization of the molecular catalysts will stabilize their molecular integrity and ensure longevity and recyclability of the resulting MOFcats. The organized environment prov...
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 1

 TERMINÉ 

Contexts, networks and participation: The social logic of political engagement (CONPOL)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The statement that individuals’ immediate social circumstances influence how they think and act in the political sphere is a truism. However, both theoretical and empirical considerations have often prevented political scientists from incorporating this logic into analyses of political behavior. In the CONPOL project we argue that it is necessary to return to the idea that politics follows a socia...
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 1

 TERMINÉ 

Marine Renewable Infrastructure Network for Enhancing Technologies 2 (MARINET2)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2021,

Integrating activities planned under MaRINET 2 build upon the achievements of the advanced community created in MaRINET FP7. MaRINET 2 will ensure the continued integration and enhancement of all leading European research infrastructure and facilities specialising in research, development and testing of offshore renewable energy systems including electrical sub systems and grid integration through...
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 39

 TERMINÉ 

Integrating spatial and genetic information via automated image analysis and interactive visualization of tissue data (TissueMaps)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Digital imaging of tissue samples and genetic analysis by next generation sequencing are two rapidly emerging fields in pathology. The exponential growth in digital imaging in pathology is catalyzed by more advanced imaging hardware, comparable to the complete shift from analog to digital images that took place in radiology a couple of decades ago: Entire glass slides can be digitized at near the ...
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 1

 TERMINÉ 

Evolutionary Stability of Ubiquitous Root Symbiosis (HeteroDynamic)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Virtually all terrestrial plants depend on symbiotic interactions with fungi. Arbuscular mycorrhizal (AM) fungi evolved over 450 million years ago, are obligate biotrophs and cannot complete their lifecycle without obtaining carbon from host roots. Mediating nutrient uptake and sequestering carbon in soil this symbiosis lie at the core of all terrestrial ecosystems. Plants on the other hand are fa...
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 1

 TERMINÉ 

Mosaic loss of chromosome Y (LOY) in blood cells - a new biomarker for risk of cancer and Alzheimer’s disease in men (DIALOY)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

My recent discoveries show that mosaic loss of chromosome Y (LOY) in peripheral blood is associated with increased risks of cancer and Alzheimer’s disease (AD). These conditions are responsible for >50% of morbidity/mortality in aging men. More than 15% of men older than 70 show some degree of LOY and these men survive on average only half as long as men without LOY. Smoking is strongly associated...
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 1

 TERMINÉ 

Technology demonstration of large-scale photo-electrochemical system for solar hydrogen production (PECSYS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The objective of the project PECSYS is the demonstration of a system for the solar driven electrochemical hydrogen generation with an area >10 m². The efficiency of the system will be >6% and it will operate for six month showing a degradation below 100 cm²) and will be subject to extensive stability optimization. Especially, the use of innovative ALD based metal oxide sealing layers will be studi...
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 6

 TERMINÉ 

Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia (TREATMENT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients...
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 9

 TERMINÉ 

Management of Climatic Extreme Events in Lakes Reservoirs for the Protection of Ecosystem Services (MANTEL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Environmental perturbations to lakes and reservoirs occur largely as episodic climatic events. These range from relatively short mixing events to storms and heat waves. While the driving events occur along a continuum of frequency and magnitude, however, their effect is generally longer lasting than the events themselves. In addition, the more extreme weather events are now becoming increasingly ...
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 8

 TERMINÉ 

Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen (U-PGx)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and ...
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 16

 TERMINÉ 

International Master in Innovative Medicine

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

REFERENCE: 564524-EPP-1-2015-1-NL-EPPKA1-JMD-MOB_IMIMTITLE: International Master in Innovative Medicine, IMIMObjectiveThe mission of the Erasmus Mundus Joint Master Degree International Master in Innovative Medicine (IMIM) is to educate a future generation of excellent translational biomedical scientists and professionals who have the skills and competences to work effectively in different multi-/...
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 7

 TERMINÉ 

Unraveling Principles of PDZ-mediated Cell Signaling (PDZnet)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role...
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 10

 TERMINÉ 

Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery (INTESTINANOS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

My research program explores molecular interplay between drug, dosage form and the complex environment of the gastrointestinal tract (GIT). Drug molecules currently being discovered to cure e.g. CNS diseases, cancer and the metabolic syndrome show poor water solubility and 70-90% of recently discovered drugs have too poor solubility to allow absorption from the GIT. For such compounds the dosage f...
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 1

 TERMINÉ 

Dynamics of Supersymmetry in Curved Space (CurvedSusy)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Quantum field theory provides a theoretical framework to explain quantitatively natural phenomena as diverse as the fluctuations in the cosmic microwave background, superconductivity, and elementary particle interactions in colliders. Even if we use quantum field theories in different settings, their structure and dynamics are still largely mysterious. Weakly coupled systems can be studied perturb...
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 2

 TERMINÉ 

HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making (HarmonicSS)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along wi...
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 39

 TERMINÉ 

Sustainable Integrated Management FOR the NEXUS of water-land-food-energy-climate for a resource-efficient Europe (SIM4NEXUS)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

Land, food, energy, water and climate are interconnected, comprising a coherent system (the ‘Nexus’), dominated by complexity and feedback. The integrated management of the Nexus is critical to secure the efficient and sustainable use of resources. Barriers to a resource efficient Europe are policy inconsistencies and incoherence, knowledge gaps, especially regarding integration methodologies and ...
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 28

 TERMINÉ 

Clean energy from ocean waves (CEFOW)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

The most advanced wave power demonstrations today have showed the feasibility of power generation with single device deployments and MW-scale performance within several testing periods of several years. The next step beyond this is to deploy multiple wave energy converters in MW-scale with improved power generation capability and demonstrate that they are able to survive rough sea conditions over ...
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 10

 TERMINÉ 

Organ-specific mechanisms of lymphatic vascular development and specialisation (LYMPHORG)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Lymphatic vasculature maintains tissue fluid homeostasis and has important emerging roles in inflammation, immunity, lipid metabolism, blood pressure regulation and cancer metastasis. Lymphatic vessels are specialised to fulfil the functional needs of different organs while diseases associated with lymphatic dysfunction frequently affect vessels of specific tissues. How functional specialisation o...
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 1

 TERMINÉ 

Spore killer genomics: elucidating causes and consequences of a fungal meiotic drive element (SpoKiGen)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

The traditional view of the genome is that of a highly coordinated network that has evolved to produce a successful individual. However, the alternative view of the genome as containing intrinsically conflicting parts that coevolve antagonistically, has recently emerged. Today, it is widely accepted that conflicts caused by selfish genetic elements is a driving force for evolutionary innovation, a...
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 1

 TERMINÉ 

Molecularly defined models of human childhood brain tumors (Medulloblastoma)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

MYC proteins like MYC and MYCN are transcription factors that are mis-regulated in more than half of all types of human cancer including medulloblastoma, the most common brain malignancy in children. The two main challenges that can guide research in the field of pediatric brain tumors is improving survival and reducing long-term detriments due to treatment toxicities, especially from craniospinal...
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 1

 TERMINÉ 

Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia (AML-VACCiN)

Date du début: 1 janv. 2016, Date de fin: 31 mars 2020,

Eradicating minimal residual disease (MRD) in patients with acute myeloid leukaemia (AML) is an area of high unmet medical need. AML is a deadly rare disease that affects both children and adults. Approximately 45% of younger AML patients who are treated will be cured, and in older patients (>60 years of age), 85% will relapse and die within 2 years.Immunotherapy has great potential for treating M...
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 12

 TERMINÉ 

Adaptive ADAS to support incapacitated drivers Mitigate Effectively risks through tailor made HMI under automation (ADASANDME)

Date du début: 1 sept. 2016, Date de fin: 29 févr. 2020,

ADAS&ME (“Adaptive ADAS to support incapacitated drivers &Mitigate Effectively risks through tailor made HMI under automation”) will develop adapted Advanced Driver Assistance Systems, that incorporate driver/rider state, situational/environmental context, and adaptive interaction to automatically transfer control between vehicle and driver/rider and thus ensure safer and more efficient road usage...
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 30

 TERMINÉ 

Optimising the management and sustainable use of forest genetic resources in Europe (GenTree)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The goal of GenTree is to provide the European forestry sector with better knowledge, methods and tools for optimising the management and sustainable use of forest genetic resources (FGR) in Europe in the context of climate change and continuously evolving demands for forest products and services. To reach its goal, GenTree will make scientific, technological and implementation breakthroughs in: (...
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 22

 TERMINÉ 

Silicon based materials and new processing technologies for improved lithium-ion batteries (SINTBAT)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

According to the European Energy Storage Technology Development Roadmap towards 2030 (EASE/EERA) energy storage will be of the greatest importance for the European climate energy objectives. The Sintbat project aims at the development of a cheap energy efficient and effectively maintenance free lithium-ion based energy storage system offering in-service time of 20 to 25 years. Insights gained from...
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 9

 TERMINÉ 

Deep-sea Sponge Grounds Ecosystems of the North Atlantic: an integrated approach towards their preservation and sustainable exploitation (SponGES)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The objective of SponGES is to develop an integrated ecosystem-based approach to preserve and sustainably use vulnerable sponge ecosystems of the North Atlantic. The SponGES consortium, an international and interdisciplinary collaboration of research institutions, environmental non-governmental and intergovernmental organizations, will focus on one of the most diverse, ecologically and biologicall...
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 19

 TERMINÉ 

European Gram Negative Antibacterial Engine (ENABLE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a...
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 42

 TERMINÉ 

Reinventing Democracy in Europe: Youth Doing Politics in Times of Increasing Inequalities (EURYKA)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2020,

The proposed project aims to study the relations between inequalities and young people's ways of doing politics as well as to advance scenarios for future democratic models and political systems in Europe that are more inclusive for young people. It has three main objectives: (1) To provide systematic evidence on the ways in which inequalities are lived by young people and (re)acted upon, explorin...
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 10

 TERMINÉ 

Advanced European Network of E-infrastructuresfor Astronomy with the SKA (AENEAS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The objective of the AENEAS project is to develop a concept and design for a distributed, federated European Science Data Centre (ESDC) to support the astronomical community in achieving the scientific goals of the Square Kilometre Array (SKA). The scientific potential of the SKA radio telescope is unprecedented and represents one of the highest priorities for the international scientific communit...
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 31

 TERMINÉ 

Role of European Mobility and its Impacts in Narratives, Debates and EU Reforms (REMINDER)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The overarching goal of the project is to understand the economic, social, institutional and policy factors that have shaped the impacts of free movement and public debates about it. It aims to help European policymakers develop policy responses that inspire public trust, ensure the fairness and sustainability of free movement, and maintain inclusive policies that reduce inequalities across the co...
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 14

 TERMINÉ 

Accelerated Early staGe drug diScovery (AEGIS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia.The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cros...
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 11

 TERMINÉ 

Meaningful Personalization of Hybrid Virtual Museum Experiences Through Gifting and Appropriation (GIFT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

"A main challenge with the development of virtual museums is establishing meaningful user experiences that allow for personal, complex and emotional encounters with art and cultural heritage. The GIFT project suggests creating meaningful personalization through digital gifting and emotional appropriation: Designs for allowing visitors to create their own museum tours as digital "mixtapes", and to ...
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 7

 TERMINÉ 

Advanced Networking for Nuclear Education and Training and Transfer of Expertise (ANNETTE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain a...
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 25

 TERMINÉ 

Values and ethics in Innovation for Responsible Technology in EUrope (VIRT-EU)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The networked future promises new relationships between people and artifacts, the private and the public, the individual and the collective. The increased networking capabilities of pervasive technologies mean that of personal data are being produced, analyzed, monetized and connected to other data streams in ways that hold both enormous potential and pose profound challenges for European society....
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 7

 TERMINÉ 

Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes (SINGEK)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism...
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 9

 TERMINÉ 

Advanced strategies for substitution of critical raw materials in photovoltaics (STARCELL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

STARCELL proposes the substitution of CRM’s in thin film PV by the development and demonstration of a cost effective solution based on kesterite CZTS (Cu2ZnSn(S,Se)4) materials. Kesterites are only formed by elements abundant in the earth crust with low toxicity offering a secure supply chain and minimizing recycling costs and risks, and are compatible with massive sustainable deployment of electr...
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 15

 TERMINÉ 

OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment (OpenRiskNet)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks su...
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 14

 TERMINÉ 

Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells with high Manufacturability (ARCIGS-M)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells with high Manufacturability (ARCIGS-M)This project´s goal is advanced materials and nanotechnologies for novel CIGS PV device architectures with efficiencies ≥ 23.0 %, thus beyond that of the current state-of-the-art technologies. The technology targets the BIPV sector and enables several innovative solutions for BIPV.The novel...
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 15