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Plus de 40 projets européens trouvés

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 TERMINÉ 

ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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 13

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte...
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 44

 TERMINÉ 

Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL) (Autonomous CLL-BCRs)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,

The proposed project aims at investigating the molecular mechanisms that activate B cell antigen receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL). While it is widely accepted that the unbroken BCR expression in CLL cells is indicative for a key role in disease development, the mechanisms that induce BCR activation and survival of malignant cells are still elusive. Using a unique re...
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 1

 TERMINÉ 

Bounded Rationality in Sensorimotor Coordination (BRISC)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Despite their many successes and great computational power and speed, why are machines still so blatantly outperformed by humans in uncertain environments that require flexible sensorimotor behavior like playing football or navigating a disaster zone? Answering this question requires understanding the mathematical principles of biological sensorimotor control and learning. Over the recent years Ba...
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 2

 TERMINÉ 

Composable Models and Software for Robotics Systems (RobMoSys)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

RobMoSys will coordinate the whole community’s best and consorted effort to build an open and sustainable, agile and multi-domain European robotics software ecosystem.RobMoSys envisions an integration approach built on-top-of, or rather around, the current code-centric robotic platforms, by means of the systematic application of model-driven methods and tools that explicitly focus on (system-of-) ...
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 9

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica...
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 17

 TERMINÉ 

Single Molecule Mechanisms of Spatio-Temporal Chromatin Architecture (ChromArch)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Chromatin packaging into the nucleus of eukaryotic cells is highly sophisticated. It not only serves to condense the genomic content into restricted space, but mainly to encode epigenetic traits ensuring temporally controlled and balanced transcription of genes and coordinated DNA replication and repair. The non-random three-dimensional chromatin architecture including looped structures between ge...
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 1

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M...
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 23

 TERMINÉ 

The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe (HYPERDIAMOND)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous p...
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 11

 TERMINÉ 

Citizenship, Recovery and Inclusive Society Partnership (CRISP)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

People with mental health problems experience significant inequalities including high levels of early mortality, morbidity, unemployment, poverty, isolation and social exclusion. This also presents major health, social and economic challenges to wider society. Our International Network unites leaders from academia, policy, practice, business and community organisations from the EU and US. Each par...
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 4

 TERMINÉ 

Quantum sensors - from the lab to the field (Q-Sense)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Q-SENSE will promote international and inter-sector collaboration for the advancement of science and the development of innovation in the area of cold atom quantum sensors. In particular it fosters a shared culture of research and innovation that turns the Nobel-prize winning ideas of cold atom research and precision measurement (Nobel prizes 1997 and 2005) into innovative products. In particular,...
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 10

 TERMINÉ 

Reliable Capacity Provisioning and Enhanced Remediation for Distributed Cloud Applications (RECAP)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

Large-scale computing systems are today built as distributed systems (for reasons of scale, heterogeneity, cost and energy efficiency) where components and services are distributed and accessed remotely through clients and devices. In some systems, in particular latency-sensitive or high availability systems, components are also placed closer to end-users (in, e.g., radio base stations and other s...
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 9

 TERMINÉ 

Multi-cloud Execution-ware for Large-scale Optimized Data-Intensive Computing (MELODIC)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

MELODIC will enable data-intensive applications to run within defined security, cost, and performance boundaries seamlessly on geographically distributed and federated cloud infrastructures. Serving the user’s needs and constraints, MELODIC will realise the potential of Cloud computing for big data and data-intensive applications by transparently taking advantage of distinct characteristics of ava...
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 7

 TERMINÉ 

A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates (ProteinConjugates)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu...
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 8

 TERMINÉ 

Automation as accepted and trustful teamMate to enhance traffic safety and efficiency (AutoMate)

Date du début: 1 sept. 2016, Date de fin: 31 août 2019,

Automation in passenger cars is constantly increasing. In order to leverage the introduction of highly automated vehicles to the market and to fully exploit the automation’s potential to improve traffic safety and efficiency the careful design of the human-machine interaction is of utmost importance. Human drivers will remain part of the system for a long time. The vision of AutoMate is a novel dr...
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 10

 TERMINÉ 

Interactive Science for Kids and Youngsters in Primary Education

Date du début: 1 oct. 2016, Date de fin: 30 juin 2019,

Skills in science are becoming an increasingly important part of basic literacy in today’s knowledge economy. To keep Europe growing, there is strong need of science-aware citizens who can make informed decisions and develop critical thinking. As confirmed by numerous EU education policy strategies and research analysis, motivation should be fostered among young people in early education, as missi...
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 8

 TERMINÉ 

Diamond Quantum Devices and Biology (BioQ)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2019,

Many of the most remarkable contributions of modern science to society have arisen from interdisciplinary work of scientists enabling novel imaging and sensing technologies (NMR, X-ray diffraction, electron microscopy). BioQ will revolutionize the state of the art to create novel sensing technologies for the broad field of life sciences research that provide unprecedented access and insight into s...
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 1

 TERMINÉ 

aDverse wEather eNvironmental Sensing systEm (DENSE)

Date du début: 1 juin 2016, Date de fin: 31 mai 2019,

Current driver assistance systems are not all-weather capable. They offer comfort and safety in sound environmental conditions. However, in adverse weather conditions where the accident risks are highest they malfunction or even fail. Now that we are progressing towards automated cars and work machines, the requirements of fully reliable environment perception are only accentuated. The project is ...
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 16

 TERMINÉ 

SITless: Exercise Referral Schemes enhanced by Self-Management Strategies to battle sedentary behaviour (SITless)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

The increase of the elderly population leads to increased prevalence of frailty, risk for poor health outcomes, and related health and social care costs. Lack of physical activity (PA) and established sedentary behaviours (SB) constitute an additional burden, as they are related to progression of chronic disease and disabling conditions. An existing initiative to battle SB and insufficient PA leve...
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 7

 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth...
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 21

 TERMINÉ 

Development of a non-invassive breath test for early diagnosis of tropical diseases (TROPSENSE)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hyda...
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 9

 TERMINÉ 

THE MILESTONE PROJECT: Managing the Link and Strengthening Transition from Child to Adult Mental Health Care (MILESTONE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and socie...
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 14

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th...
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 27

 TERMINÉ 

Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can...
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 20

 TERMINÉ 

New technological advances for the third generation of Solar cells (GOTSolar)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

It is believed that solid-state perovskite solar cells (PSCs) will be the next generation of power source, contributing for fostering the use of photovoltaics in buildings’ roofs and facades. Actually, their transparency, various possibilities of colors and high kWh/nominal power ratio offer to PSCs an opportunity to conquer markets that are not attainable by traditional silicon solar cells. To tu...
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 7

 TERMINÉ 

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express...
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 49

 TERMINÉ 

Enabling CLoud Orchestration, Performance and Cost Efficiency Tools for QoE Enhancement and Provider Ranking (CloudPerfect)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2018,

Cloud environments are notorious for their lack of stability in performance characteristics, a feature that makes it extremely difficult for owners of time-critical applications to make the decisive step for migration and owners of SaaS to be unable to present performance vs cost tradeoffs to their customers when acting as IaaS customers. CLOUDPERFECT aims at delivering a set of tools and processe...
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 8

 TERMINÉ 

RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con...
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 30

 TERMINÉ 

Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di...
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 18

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

European Clearing House for Open Robotics Development Plus Plus (ECHORD Plus Plus)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Description ECHORD++ will create new opportunities for European robotics researchers to work directly with SME/start-ups and new users/customers to create innovative products. ECHORD++ will continue ECHORD’s two pillars, “experiments” and “structured dialogue”, taking advantage of experience and investment in the infrastructure. In addition,...
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 68

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Robust and Reliable Environment Sensing and Situation Prediction for Advanced Driver Assistance Systems and Automated Driving (RobustSENSE)

Date du début: 1 juin 2015, Date de fin: 31 mai 2018,

Today’s driver assistance systems offer comfort and safety in sound environmental conditions. However, in harsh environment conditions – when needed most – systems stop working due to reduced sensor information quality. Targeting to the area of highly automated driving the improvement of perception, decision and planning under adverse conditions is one of the main challenges to be addressed. Robus...
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 15

 TERMINÉ 

A combined evolutionary and proteomics approach to the discovery, induction and application of antiviral immunity factors (Anti-Virome)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"Humans are equipped with a variety of intrinsic immunity or host restriction factors. These evolved under positive selection pressure for diversification and represent a first line of defence against invading viruses. Unfortunately, however, many pathogens have evolved effective antagonists against our defences. For example, the capability of HIV-1 to counteract human restriction factors that int...
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 1

 TERMINÉ 

Graphene-based disruptive technologies (GrapheneCore1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS...
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 158

 TERMINÉ 

Rydberg Quantum Simulators (RYSQ)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

Quantum Simulators provide new levels of understanding of equilibrium and out-of-equilibrium properties of many-body quantum systems, one of the most challenging problems in physics. The main objective of the RYSQ project is to use Rydberg atoms for quantum simulations, because their outstanding versatility will allow us to perform a great variety of useful quantum simulations, by exploiting diffe...
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 16

 TERMINÉ 

Knowledge-Based Information Agent with Social Competence and Human Interaction Capabilities (KRISTINA)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

In Europe, migration is tradition – and not only since the European legislation changed towards free migration of European citizens. This is not free of challenges. Especially in the case of care, migrants, often face a double challenge: (i) not to speak the language and not to be acquainted with the culture of the resident country, and (ii) be unfamiliar with the care and health administrations o...
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 10

 TERMINÉ 

Quantum Simulation on a Photonic Chip (QUCHIP)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

Simulation is a fundamental computational tool for modern science with applications ranging from drug design to materials science. Quantum simulators have the potential to revolutionize the way simulations are performed by accessing system sizes that are untractable in classical machines. As a result, they will become a suite of powerful and precise instruments enabling the investigation of releva...
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 9

 TERMINÉ 

Innovative Nanoformulation of Antimicrobial Peptides to Treat Bacterial Infectious Diseases (FORMAMP)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

Resistance to traditional antibiotics is a rapidly increasing problem that in a few years could make infections impossible to treat and bring the state of medical care back to the pre-antibiotic era from the beginning of the last century. Antimicrobial peptides (AMPs) have a huge potential as new therapeutics against infectious diseases as they are less prone to induce resistance due to their fast...
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 18

 TERMINÉ 

Cold Molecular Ions at the Quantum Limit (COMIQ)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"COMIQ (COld Molecular Ions at the Quantum limit)will investigate how cooling, trapping, and control techniques applied molecular ion can expand the realm of quantum technology, enhance precision meaurements on molecular systems and lead to chemistry at the ultracold quantum limit."
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 10