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28 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Enhanced Delivery Ecosystem for Neurosurgery in 2020 (EDEN2020)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Due to an aging population and the spiralling cost of brain disease in Europe and beyond, EDEN2020 aims to develop the gold standard for one-stop diagnosis and minimally invasive treatment in neurosurgery. Supported by a clear business case, it will exploit the unique track record of leading research institutions and key industrial players in the field of surgical robotics to overcome the current ...
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 9

 TERMINÉ 

Treating stroke with Affibody molecules targeting the inflammatory mediator HMGB1 (COUNTERSTROKE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 perso...
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 6

 TERMINÉ 

AEGLE (Ancient Greek: Αἴγλη) – An analytics framework for integrated and personalized healthcare services in Europe (AEGLE)

Date du début: 1 mars 2015, Date de fin: 31 août 2018,

The data generated in the health domain is coming from heterogeneous, multi-modal, multi-lingual, dynamic and fast evolving medical technologies. Today we are found in a big health landscape characterized by large volume, versatility and velocity (3Vs) which has led to the evolution of the informatics in the big biodata domain. AEGLE project will build an innovative ICT solution addressing the who...
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 14

 TERMINÉ 

Investigation of the role of CYLD in Chronic Lymphocytic Leukaemia (CIRCLE)

Date du début: 15 avr. 2016, Date de fin: 14 avr. 2018,

This project will investigate the role of CYLD in Chronic Lymphocytic Leukaemia (CLL). CYLD is a deubiquinating enzyme acting as a tumour suppressor in numerous tumours. CLL is characterized by the accumulation of B-lymphocytes. It affects mostly the elder and has a high incidence rate in Europe. Recent data from CYLD knockout murine models indicate a link between CYLD and CLL, however the approac...
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 1

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2016, Date de fin: 30 sept. 2017,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

In vivo dynamics of antibody responses to lymph-borne viruses (IVM-VIRUS-NAB)

Date du début: 1 févr. 2012, Date de fin: 30 juin 2017,

Objective. Our objective is to elucidate how neutralizing antibody (nAb) responses against live viruses are generated in vivo within lymph nodes (LNs). To this end we will make use of state-of-the-art imaging technology (i.e. multiphoton intravital microscopy [MP-IVM]), fluorescent replication-competent viruses and dedicated mouse models.Background/Rationale. nAbs are critical for virus control, p...
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 1

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor...
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 13

 TERMINÉ 

INternational VEnue for poSTgraduate education (INVEST)

Date du début: 1 nov. 2011, Date de fin: 30 avr. 2017,

The Università Vita-Salute San Raffaele (USR) is a vibrant and acclaimed private University in Milan, Italy, registered by the Italian Ministry of Research. Together with the San Raffaele Research Institute and the San Raffaele Hospital, both controlled by the San Raffaele Foundation hereafter referred to as HSR, it is part of the San Raffaele Biomedical Science Park, hereafter referred to as SRBS...
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 1

 TERMINÉ 

Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy (INSERT)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in...
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 10

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms...
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 32

 TERMINÉ 

Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders (TARGETBRAIN)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain re...
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 10

 TERMINÉ 

Towards clinical translation of new gene targeting technologies for correcting inherited mutations and empowering adoptive immunotherapy of cancer (SUPERSIST)

Date du début: 1 mai 2013, Date de fin: 31 oct. 2016,

Substantial evidence supports the therapeutic potential of ex vivo gene therapy based on Hematopoietic Stem Cell (HSC) or T lymphocytes to treat inherited diseases or cancer. Yet, the intrinsic limitations of current gene replacement approaches based on semi-randomly integrating vectors, and the occurrence in some clinical trials of severe adverse events related to gene transfer, prevent safe depl...
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 5

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2015, Date de fin: 30 sept. 2016,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Date du début: 1 mars 2012, Date de fin: 30 juin 2016,

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n...
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 18

 TERMINÉ 

Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

 TERMINÉ 

Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression (TARGETINGGENETHERAPY)

Date du début: 1 mai 2010, Date de fin: 31 janv. 2016,

Hematopoietic stem cell gene therapy has a tremendous potential to treat human disease. Yet, in conjunction with the first successful results in the clinic, severe adverse events linked to the gene transfer protocol were reported. Recently, we provided proof-of-principle of two new powerful strategies to improve the efficacy and safety of gene transfer: 1) regulating transgene expression by exploi...
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 3

 TERMINÉ 

EUropean TRanslational training for Autoimmunity & Immune manipulation Network (EUTRAIN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Immune-mediated inflammatory diseases (IMID) are important health challenges in Europe and beyond, afflicting an estimated 5-8% of the total population. IMID with an onset during childhood such as Juvenile Idiopathic Arthritis (JIA) cause particular concern as pediatric patients form an especially vulnerable group. Currently there is no safe and cost-effective cure for JIA and related juvenile IMI...
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 11

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2014, Date de fin: 30 sept. 2015,

Our mobility project was born - and renewed yearly - from the analysis of the training needs of the University and its staff and it is a priority objective in the context of our strategies aimed at the improvement of teaching and training activities. The context in which the program was born is certainly different from the present. The University was founded in 1996; while finding immediately its ...
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 1

 TERMINÉ 

Hydroxitirosol, a new generation of microbicides targeting HIV through antiviral and anti-inflammatory pathways (AIM-HIV)

Date du début: 1 déc. 2012, Date de fin: 31 mai 2015,

Since the first cases of AIDS were reported 30 years ago, HIV remains a difficult target for the research field. Although there is no cure for AIDS, HIV infection can be prevented, however in many countries across the world access to prevention and treatment services is limited. Global leaders have pledged to work towards universal access to HIV prevention and care, so that millions of deaths can ...
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 4

 TERMINÉ 

Atopic diseases in changing climate, land use and air quality (ATOPICA)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,

There is an urgent need to understand how global and regional climate, land use and air quality changes will impact human health. Our consortium constitutes an innovative and multidisciplinary approach to explore the combined pan-European impact of changes in climate, land use and air pollution on allergen pollen-induced diseases through a chain of quantitative physical and statistical models. We ...
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 11

 TERMINÉ 

Pan-European network for the study and clinical management of drug resistant tuberculosis (TB PAN-NET)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2014,

"This proposal will establish an integrated and synergistic network to address the challenge of multiple drug resistant tuberculosis (MDR-TB) facing the EU. The objective will be attained through the establishment of a European consortium of expert partners with extensive experience in the conduct of basic and clinical research relating to MDR-TB, TB control and epidemiology. This Consortium will...
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 32

 TERMINÉ 

Quantifying transcription factor search mechanism by three-dimensional single molecule tracking (SMT of TFs)

Date du début: 16 avr. 2012, Date de fin: 15 avr. 2014,

Transcription factors (TFs) are capable to identify their target sites on DNA in a extremely efficient fashion. The observation that a simple 3D diffusion search cannot account for such efficient targeting has led to different mechanisms to be proposed in the last decades, including compact exploration induced by facilitated diffusion (i.e. combination of 1D sliding and 3D diffusion) or by fracta...
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 2

 TERMINÉ 

"""Role of Nonlinear Dynamics of NF-kB in Inflammation""" (NonLin-kB)

Date du début: 15 mars 2012, Date de fin: 14 mars 2014,

NF-kB is a family of transcription factors that coordinately control hundreds of genes involved in many steps of inflammatory processes, from microbial killing to cancer. When inflammatory stimuli hit the cell surface, NF-kB undergoes several cycles of nucleus-to-cytoplasm translocations, resulting in oscillations of nuclear NF-kB concentrations and activity.At single cell level, live imaging and ...
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 1

 TERMINÉ 

Novel Approaches to Bacterial Target Identification, Validation and Inhibition (NABATIVI)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

Despite the advent of the antibiotic era, infectious diseases retain their pre-eminent position as major worldwide causes of morbidity and mortality. This problem has been worsen by the emergence of multi-antibiotic resistant bacteria and the failure of Pharmaceutical company drug discovery programmes to design antibiotics with truly novel modes of action. NABATIVI has put together a unique consor...
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 10

 TERMINÉ 

Persisting Transgenesis (PERSIST)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize...
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 29

 TERMINÉ 

Diagnostic Enhancement of Confidence by an International Distributed Environment (DECIDE)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2013,

DECIDE (Diagnostic Enhancement of Confidence by an International Distributed Environment), aims at creating a e-Infrastructure to enhance the diagnostic confidence in chronic brain diseases such as Alzheimer and dementia. Proper management of these neurodegenerative diseases are thought to be very important in terms of health-economical point of view. The DECIDE infrastructure will provide the med...
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 13

 TERMINÉ 

Next Generation HIV-1 Immunogens inducing broadly reactive Neutralising antibodies (NGIN)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

"The elicitation of broadly neutralising antibodies (Nab) remains the primary and most challenging goal in HIV-1 vaccine development. Although a few anti-HIV-1 monoclonal antibodies with broadly neutralising capability have been isolated from infected individuals, none of the immunization strategies thus far explored has proven effective in inducing similar antibodies. Objective of this applicatio...
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 18

 TERMINÉ 

Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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 11