Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts (Lifebrain)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic an...
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16
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TERMINÉ
Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention...
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9
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TERMINÉ
Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in...
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17
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TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte...
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44
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TERMINÉ
Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v...
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9
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TERMINÉ
Power of Algorithms in Discrete Optimisation (PowAlgDO)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Convex relaxations, such as linear and semidefinite programming, constitute one of the most powerful techniques for designing efficient algorithms, and have been studied in theoretical computer science, operational research, and applied mathematics. We seek to establish the power convex relaxations through the lens of, and with the extensions of methods designed for, Constraint Satisfaction Proble...
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1
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TERMINÉ
Dis-inhibitory circuits in the human cerebral cortex (INHIBITHUMAN)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Temporal co-ordination of the activity of cortical neurons underlies cognitive processes. Intracortical inhibitory circuits set temporal windows for modulation of glutamatergic pyramidal cell firing. In non-human mammals, the activity of the GABAergic neurons is governed by other specialised GABAergic neurons, which can dis-inhibit pyramidal cells. The overarching aim of this project is to define ...
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2
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TERMINÉ
High-density cortical implants for cognitive neuroscience and rehabilitation of speech using brain-computer interfaces. (BrainCom)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
The goal of BrainCom is to develop a new generation of neuroprosthetic devices for large-scale and high density recording and stimulation of the human cortex, suitable to explore and repair high-level cognitive functions. Since one of the most invalidating neurospychological conditions is arguably the impossibility to communicate with others, BrainCom primarily focuses on the restoration of speech...
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10
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TERMINÉ
Perception Ultrasound by Learning Sonographic Experience (PULSE)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
PULSE will develop a new generation of ultrasound imaging capabilities to revolutionize the use of this low-cost and portable imaging technology across clinical medicine worldwide. The greatest barrier to the universal implementation of ultrasound (US) in clinical medicine today is the need to train sonographers to the highest level to ensure diagnostic images are of consistently high quality and ...
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1
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TERMINÉ
Resolving Morpho-Phonological Alternation: Historical, Neurolinguistic, and Computational Approaches (MOR-PHON)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
In morpho-phonological alternations the shapes of morphemes differ between morphologically related word forms. In these alternations the morphological environment is also implicated (revére ~ réverence verb [iː] ~ noun [ɛ] and stress differ) unlike alternations which are conditioned only by the phonological environment.The opaque phonological relationship between morphologically related forms has ...
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1
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TERMINÉ
Divergent modes of ritual, social cohesion, prosociality, and conflict. (RitualModes)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
The project aims to establish an authoritative scientific framework for understanding the relationship between group ritual, social cohesion, and pro-group behaviour. Rituals have shaped human societies for millennia, but the exact social consequences of rituals are poorly understood. The proposed research will identify the fundamental components of rituals worldwide and chart their effects on pat...
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2
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TERMINÉ
CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY (CANDICE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
"150 years after Broca's seminal statement "Nous parlons avec l'hémisphère gauche" we still do not know how or why we have this bias. I propose that by studying cases of impaired language development and combining genetic and neuropsychological approaches we will be able to make a leap forward in our understanding of the quintessentially human characteristic of functional cerebral asymmetry. I arg...
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1
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TERMINÉ
Metacognition of Concepts (MetCogCon)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
This project will investigate the thoughts and feelings that accompany the use of concepts. Concepts lie at the heart of the extraordinary power of the human mind. They are the building blocks of thought, the tools with which we think. Like physical tools, they can be more or less dependable, more or less fit for purpose: e.g. for most people GENE feels like a better concept than MEME. We have an ...
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3
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TERMINÉ
Higgs bundles: Supersymmetric Gauge Theories and Geometry (HIGGSBNDL)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, t...
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2
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TERMINÉ
Large Scale Structure Constraints of General Relativity (GravityLS)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
The past decade has witnessed a phenomenal success in relativistic cosmology. It is now possible to constrain the structure, content and evolution of the Universe with an accuracy of a few percent. The current focus of cosmology is to understand some of the fundamental problems in physics such as: the accelerated expansion of the universe, the nature of dark energy and dark matter and the initial ...
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1
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TERMINÉ
Adaptive Optical Microscopy Systems: Unifying theory, practice and applications (AdOMiS)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and...
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1
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TERMINÉ
A Consolidated Library of Anglo-Saxon Poetry (CLASP)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
As elsewhere in Europe, Anglo-Saxon England saw a development from an oral, vernacular, native, and pagan culture to one that was primarily literate, Latinate, imported, and Christian; and such a transition is clearest in Anglo-Saxon verse. CLASP will focus on all surviving verse of Anglo-Saxon England, composed in Old English and Anglo-Latin over a period of over four centuries (c. 670–1100 CE), ...
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1
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TERMINÉ
Monumental Art of the Christian and Early Islamic East: Cultural Identities and Classical Heritage (HERITAGE)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
This project will analyse the monumental art (large decorative programmes on buildings) of two areas of the former eastern Roman Empire which came under Islamic rule but which have never been the subject of an integrated comprehensive study: Egypt and Syro-Palestine (modern Syria, Jordan, Lebanon, and Israel/Palestine). It aims to determine systematically how the strength and nature of the local ‘...
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1
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TERMINÉ
Cities in Global Financial Networks: Financial and Business Services and Developmentin the 21st Century (CityNet)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
Financial and business services (FABS), including law, accounting, and business consulting, have been one of the most dynamic sectors of the world economy, with a fivefold rise in real value added since 1980. Although FABS are central to the processes of globalisation, financialisation, urbanisation and development, our understanding of the sector in the context of tumultuous changes of the early ...
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1
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TERMINÉ
Vision-based Guidance and Control in Birds, with Applications to Autonomous Unmanned Aircraft (HawkEye)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
Birds have been called “une aile guidée par un oeil”, and whilst they possess many senses besides vision, their wings are indeed guided largely by their eyes. Nevertheless, we know surprisingly little of how birds use vision to guide their flight, and almost nothing of the underlying guidance and control laws. This is an extraordinary omission, and unfortunate given the importance that vision is ...
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1
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TERMINÉ
Family size matters: How low fertility affects the (re)production of social inequalities (FAMSIZEMATTERS)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
This is the first comprehensive study on the consequences of low fertility for the (re)production of social inequalities. Inequalities in socio-economic well-being, including gender inequalities and regional inequalities, are reproduced from generation to generation. The family plays a central role in the reproduction of social inequalities. Over the last 5 decades, most societies in Europe and Ea...
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1
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TERMINÉ
Randomness and pseudorandomness in discrete mathematics (RanDM)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
Discrete mathematics has seen enormous advances in the last few years, with solutions being found to a number of famous and long-standing questions, such as the Erdos distinct distance problem and the existence conjecture for combinatorial designs. Much of this progress owes to an increased understanding of random and pseudorandom objects. An entire framework, known as the probabilistic method, ha...
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1
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TERMINÉ
A Probe of the Periodic Elements for Life in the Sea (APPELS)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
"Chemical elements are the building blocks of life. The major elements, C, H. O, N, P, S are easily recognised as essential nutrients, but their use by life relies on metalloproteins. The identity of the metal centres of these metalloproteins and even the broader palette of trace elements fundamental to life are remarkably poorly known. Whole genomes remain opaque to decoding of this bioinorganic ...
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1
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TERMINÉ
Elucidating natural bilayer lipid environments (ENABLE)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
Excising a membrane protein from its natural environment, preserving the lipid bilayer, and characterising the lipids that surround it is the ‘holy grail’ of membrane protein biophysics. However, with some 40,000 different lipid structures the challenges we face in understanding selective binding arise not just from the complexity and dynamics of the lipidome, but also from the transient nature o...
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1
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TERMINÉ
Discovering how polycomb domains form and function in gene regulation (PolyDomFormFuncReg)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
Polycomb group chromatin modifying systems are essential for normal gene regulation and development, and alterations in their activity are a hallmark of a broad range of cancers. Although the chromatin modifications placed by the two central polycomb protein complexes (PRC1 and PRC2) are well-characterized, how this fascinating system selects its target sites in vivo, and then forms polycomb chrom...
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1
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TERMINÉ
Foundations of Factorized Data Management Systems (FADAMS)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
The objective of this project is to investigate scalability questions arising with a new wave of smart relational data management systems that integrate analytics and query processing. These questions will be addressed by a fundamental shift from centralized processing on tabular data representation, as supported by traditional systems and analytics software packages, to distributed and approximat...
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1
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TERMINÉ
Search for a new form of matter: the sterile neutrino (SOLID)
Date du début: 1 juin 2016, Date de fin: 31 mai 2021,
The goal of this proposal is to search for an entirely new kind of matter. This type of matter called a sterile neutrino doesn’t interact with known particles and can only manifest itself through quantum mixing with the three neutrinos of the standard model, the prevailing theory of particle physics. The known neutrinos are by far the most abundant massive particles in the Universe. More than 70 y...
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4
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TERMINÉ
Low-dimensional topology in Oxford (OXTOP)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
This project aims to build a group that brings together experts in gauge-theoretic, geometric, and group-theoretic techniques. It consists of 4 branches. 1. Cobordism maps in knot Floer homology (HFK). Defined by the PI, these should yield invariants of surfaces in 4-manifolds. Hence, they could be used to bound the 4-ball genus and the unknotting number, providing a tool for finding a counterexam...
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1
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TERMINÉ
Terrestrial vertebrates and the evolutionary origins of morphological diversity (TEMPO)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Explaining the great disparity of organismal form is a central goal of biological research. However, despite many decades of inquiry, there is little understanding of how evolution gave rise to this disparity. Key hypotheses predict changes in macroevolutionary modes through geological time: rates of evolution may either have decreased as global niche space became crowded, or increased due to accu...
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1
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TERMINÉ
Autocatalysis: A bottom-up approach to understanding the origins of life (Autocat)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
"The origin of life is not well understood, and is one of the great remaining questions in science. Autocatalytic chemical reactions have been extensively studied with the aim of providing insight into the principles underlying living systems. In biology, organisms can be thought of as imperfect self-replicators, which produce closely related species, allowing for selection and evolution. Autocata...
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1
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TERMINÉ
Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy (PRECIOUS)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
PRECIOUS aims at scaling-up biodegradable nanomedicines for multimodal precision cancer immunotherapy.With 3.5 million cancer patients in Europe every year, new cancer medicines are eagerly awaited, notably for prostate and ovarian cancer.Systemically applied new immunotherapies are promising, but their toxicity is a hurdle. Vaccination against cancer is safe but rather disappointing: the microenv...
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11
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TERMINÉ
Chemical biology approaches to unraveling the histone code (EPITOOLS)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
Posttranslational modifications on histones play crucial roles in the epigenetic regulation of eukaryotic gene expression. Chemical modifications that occur on histone tails include acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation. This chemical diversity together with the positions and combinations of these modifications give rise to complex networks of highly controlled...
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1
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TERMINÉ
External Control of Liquid Nanofilms for Switchable Friction and Adhesion (LIQUISWITCH)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
The overall vision of the project is to demonstrate methods for switching friction and adhesion – such as “switch off friction” or “switch on adhesion” – reversibly and with remote control. My hypothesis is that fluids confined to nanofilms between solid objects can be designed to dramatically alter their surface properties under the influence of applied fields, and so can be used to switch fricti...
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1
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TERMINÉ
Genetic and Small Molecule Modifiers of Lysosomal Function (LysoMod)
Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,
LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteom...
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8
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TERMINÉ
REnaissance of Places with Innovative Citizenship and TEchnolgy (REPLICATE)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,
The objective of REPLICATE is to demonstrate Smart City technologies in energy, transport and ICT in districts in San Sebastia, Florence and Bristol addressing urban complexity and generate replication plans in other districts and in follower cities of Essen,Nilufer and Lausanne.Main challenges for cities are to increase the overall energy efficiency, to exploit better local resources in terms of ...
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37
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TERMINÉ
Scaling up Safe Surgery for District and Rural Populations in Africa (SURG-Africa)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
In sub-Saharan Africa 95% of the population has no access to surgical services. In this region surgery – a proven and often life-saving intervention – is only accessible to urban populations, with only one surgeon per 2.5 million people in rural areas. Emerging evidence demonstrates that major surgery can be undertaken safely and effectively at district hospitals, making it accessible to otherwise...
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6
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TERMINÉ
Advanced materials solutions for next generation high efficiency concentrated solar power (CSP) tower systems (NEXTOWER)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
NEXTOWER shall introduce a set of innovative materials to boost the performance of atmospheric air-based concentrated solar power (CSP) systems to make them commercially viable. In particular, tower systems are appealing for the great environmental compatibility and offer tremendous potential for efficient (electrical and thermal) power generation. Yet, their industrial exploitation has been so fa...
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18
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TERMINÉ
Advanced Radio Astronomy in Europe (RadioNet)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
RadioNet is a consortium of 28 institutions in Europe, Republic of Korea and South Africa, integrating at European level world-class infrastructures for research in radio astronomy. These include radio telescopes, telescope arrays, data archives and the globally operating European Network for Very Long Baseline Interferometry (EVN). RadioNet is de facto widely regarded to represent the interests o...
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29
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TERMINÉ
Optical Infrared Coordination Network for Astronomy (OPTICON)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations...
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34
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TERMINÉ
Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a...
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