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 TERMINÉ 

Early-life stressors and LifeCycle health (LIFECYCLE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur...
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 19

 TERMINÉ 

Fostering responsive mental health systems in the Syrian refugee crisis (STRENGTHS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

STRENGTHS aims to provide effective community-based health care implementation strategies to scale-up the delivery and uptake of effective mental health interventions in different country contexts. The current refugee crisis across Europe and the Middle East effects both individual refugees’ psychological well-being, as they face extreme stressors in their flight from their home country, but also ...
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 15

 TERMINÉ 

THAWing permafrost: the fate of Soil Organic Matter in the aquatic Environment (THAWSOME)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

As the Arctic permafrost region warms, its large organic carbon (OC) pool becomes vulnerable to decomposition. This generates greenhouse gases (GHG) that in turn fuel increased surface warming: the permafrost carbon feedback. Higher temperatures will jump-start the coupling between the carbon and hydrological cycle, allowing for the introduction of previously frozen OC pools in aquatic systems. Th...
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 1

 TERMINÉ 

NEURASMUS : A EUROPEAN MASTER IN NEUROSCIENCE : ADVANCED COURSE AND RESEARCH TRAINING

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

With brain diseases responsible for 35% of Europe’s disease burden, neuroscience research is pivotal in fighting the challenges faced by our health systems. Meanwhile, pharmaceuticals across Europe report a shortage of neuroscientists properly trained in experimental methodologies and the latest techniques used in clinical and industrial research. Neurasmus is a two-year joint Master Programme in ...
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 5

 TERMINÉ 

The Proton Size Puzzle: Testing QED at Extreme Wavelengths (QED-PROTONSIZE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

A key component of the Standard Model is Quantum Electrodynamics (QED). QED explains e.g. the anomalous magnetic moment of the electron and small energy shifts in the energy structure of atoms and molecules due to vacuum fluctuations. After decades of precision measurements, especially laser spectroscopy in atomic hydrogen, QED is considered the most successful and best-tested theory in physics. H...
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 1

 TERMINÉ 

Scientific Top Training in Antimicrobial Research (AIMMS STAR-PLUS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The Amsterdam Institute for Molecules, Medicines and Systems (AIMMS, www.aimms.vu.nl) offers an innovative selection procedure for international Top Master's Students to train a new generation of top scientists who can contribute to solving the problem of bacterial, viral and parasitic diseases.A multitude of microbes, and their resistance in particular, threaten the health of European citizens an...
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 1

 TERMINÉ 

The Human Behavioral Immune System: Consequences for Health and Innovation (HBIS)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Modern innovations such as soap, condoms, and indoor plumbing have allowed billions of people to reduce their contact with viruses and bacteria and, as a result, dramatically increase length and quality of life. But how did members of the genus homo avoid pathogens for the two million years that preceded these technological innovations and, more broadly, discoveries that infectious disease is caus...
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 1

 TERMINÉ 

Towards evidence-based tailored implementation strategies for eHealth (ImpleMentAll)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2021,

ImpleMentAll will develop, apply, and evaluate tailored implementation strategies in the context of on-going eHealth implementation initiatives in the EU and beyond. Common mental health disorders account for an alarming proportion of the global burden of disease. Being regarded as an evidence-based psychotherapeutic eHealth intervention, Internet-based Cognitive Behavioural Therapy (iCBT), has th...
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 19

 TERMINÉ 

PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

PROMISS (PRevention Of Malnutrition In Senior Subjects in the EU) is a multi-country project aiming to turn the challenge of tackling malnutrition in community-dwelling older persons into an opportunity for healthy ageing for the future. The PROMISS consortium contains worldwide expertise in epidemiology, clinical trials, geriatrics, nutrition, physical activity, microbiomics, as well as in behavi...
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 24

 TERMINÉ 

PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES. (PANA)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new ef...
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 11

 TERMINÉ 

Peptide-derived bioavailable macrocycles as inhibitors of protein-RNA and protein-protein interactions (PEP-PRO-RNA)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

The objective of this proposal is the elucidation of general principles for the design of bioavailable peptide-derived macrocyclic compounds and their use for the development of inhibitors of protein‒protein (PPI) and protein‒RNA interactions (PRI). Over the last decade, drug discovery faced the problem of decreasing success rates which is mainly caused by the fact that numerous novel biological t...
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 1

 TERMINÉ 

Social Cognition in Adolescents: Brain Networks and Social Networks (SCANS)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

The forming of social bonds is an evolutionary imperative, and a rich target for empirical research. Social scientists have scrutinized the structure of the elaborate social networks that characterize today’s society. Neuroscientists have elucidated the brain mechanisms underlying our ability to navigate this social world. Yet, these research lines have been largely separated. This proposal aims t...
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 1

 TERMINÉ 

Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream (INTERWASTE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The overall vision of INTERWASTE is to develop scientific understanding of issues related to environmental contamination with toxic organic chemicals (specifically flame retardants (FRs) and pharmaceutical and personal care products (PPCPs)) arising from their presence in the waste stream. Specific research objectives include: (a) exchange of knowledge of and best practice in methods for rapid and...
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 12

 TERMINÉ 

Localized Surface Plasmon Resonance in doped semiconductor nanocrystals (SONAR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Doped semiconductor nanocrystals (dSNCs) are an exciting emerging material. Carrier densities in the range of 1020-1021cm-3 lead to localized surface plasmon resonances (LSPRs) in the near infrared (NIR). Prominent examples are copper chalcogenides, where doping occurs via vacancy formation, and metal oxides (MOs) that show plasmonic response due to impurity doping. Excitingly, both materials disp...
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 4

 TERMINÉ 

Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders (COSYN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity. Our aims are: (1) Understand comorbidity by...
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 14

 TERMINÉ 

Comparing the effectiveness and safety of additional low-dose glucocorticoid in treatment strategies for elderly patients with rheumatoid arthritis (GLORIA)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

GLORIA aims to prove that the addition of chronic low dose glucocorticoids (GC) to current antirheumatic therapy is highly cost-effective and safe in elderly patients with rheumatoid arthritis (RA). RA is a frequent (affecting > 2% of the elderly population), painful and disabling chronic disease with high societal costs. RA is associated with multiple comorbidities, polypharmacy and adverse event...
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 13

 TERMINÉ 

A Citizen Observatory and Innovation Marketplace for Land Use and Land Cover Monitoring (LANDSENSE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Currently within the EU’s Earth Observation (EO) monitoring framework, there is a need for low-cost methods for acquiring high quality in-situ data to create accurate and well-validated environmental monitoring products. The aim of the LandSense project is to build a far reaching citizen observatory for Land Use and Land Cover (LULC) monitoring that will also function as a technology innovation ma...
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 17

 TERMINÉ 

The molecular genetic architecture of educational attainment and its significance for cognitive health (EdGe)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Since many social and economic outcomes are moderately heritable, it is in principle possible to discover genetic variants associated with them. Such discoveries could yield new insights into the causal pathways underlying human behaviour, the complex interplay of environmental and genetic factors, and the relationship between socio-economic traits and health.This proposal builds on a recent genom...
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 1

 TERMINÉ 

Probing Physics beyond the Standard Model from Molecules (NEWPHYS-MOLECULES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The Standard Model of physics is incomplete. Gravity is not understood at the quantum level, dark matter and dark energy are not explained, and (string)-theories searching to cover these shortcomings are only consistent in higher-dimensional spaces, while only four of those dimensions are observed. The mystery of finely tuned strengths of the fundamental forces, providing us with a Universe of com...
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 1

 TERMINÉ 

Releasing Prisoners Of The Paradigm: Understanding How Cooperation Varies Across Contexts In The Lab And Field (COOPERATION)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cooperation is essential for mitigating conflict between individual and collective interests in relationships and groups, such as providing public goods and conserving resources. Most research testing psychological and economic theory of cooperation has applied a highly specific lab method (e.g., the prisoner’s dilemma) that unnecessarily constrains the applicability of research findings. The disc...
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 1

 TERMINÉ 

Improving the accuracy and reliability of electronic structure calculations: New exchange-correlation functionals from a rigorous expansion at infinite coupling strength (corr-DFT)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

By virtue of its computational efficiency, Kohn-Sham (KS) density functional theory (DFT) is the method of choice for the electronic structure calculations in computational chemistry and solid-state physics. Despite its enormous successes, KS DFT’s predictive power and overall usefulness are still hampered by inadequate approximations for near-degenerate and strongly-correlated systems. Crucial ex...
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 1

 TERMINÉ 

It’s not my fault I am aggressive, they picked on me: How early peer relations affect DNA methylation and neurocognitive development in children (socio-bio interplay)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

Think about the day you took your child to kindergarten for the first time. You were worried. Worried about the social experiences of your child. Would peers like your child, or would it get bullied, or rejected by classmates? Many children have positive social school experiences, but 10-15% of children become rejected, victim of bullying, have few friends and have poor relations with teachers. Su...
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 1

 TERMINÉ 

PET Imaging in Drug Design and Development (PET3D)

Date du début: 1 juin 2016, Date de fin: 31 mai 2020,

The drug development strategy currently pursued by the pharmaceutical industry worldwide is inefficient and unsustainable for the health care system. To keep the latter affordable, drug development should become more efficient and drug treatment should become more “personalized” and “rationalized”. Molecular imaging can play a pivotal role in changing the landscape of drug design/development and i...
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 8

 TERMINÉ 

Restoring Trust in the cyber space: a Systems Security Proposal (PROTASIS)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2020,

Fueled by a string of high profile attacks and recent revelations about unprecedented cyber surveillance, interest in systems security is rising-not just among industry and governments, but even among individual citizens across Europe. Corporate organizations worry about the viability of their businesses, nation states about cyber attacks by other nation states or terrorist groups, and citizens ab...
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 6

 TERMINÉ 

Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time (MDS-RIGHT)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Myelodysplastic syndromes (MDS) are chronic bone marrow malignancies of the elderly, complicated by severe anaemia. MDS significantly affects quality-adjusted survival and it imposes an increasing financial burden on patients and healthcare (HC) systems. The burden of disease is expected to worsen in the future, given the aging EU population and newly identified MDS cases among those diagnosed wit...
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 16

 TERMINÉ 

High-resolution microscopy without lenses: a new generation of imaging technology (Lensless)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Lensless imaging is an elegant approach to microscopy, in which a sharp image of an object is retrieved by numerical means rather than by actual optical components such as lenses. Such an approach allows high-resolution imaging using only a light source and an image sensor. Multi-wavelength phase retrieval (Witte et al., patent application PCT/NL2013/050618) provides a general framework for lensle...
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 1

 TERMINÉ 

Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia (AML-VACCiN)

Date du début: 1 janv. 2016, Date de fin: 31 mars 2020,

Eradicating minimal residual disease (MRD) in patients with acute myeloid leukaemia (AML) is an area of high unmet medical need. AML is a deadly rare disease that affects both children and adults. Approximately 45% of younger AML patients who are treated will be cured, and in older patients (>60 years of age), 85% will relapse and die within 2 years.Immunotherapy has great potential for treating M...
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 12

 TERMINÉ 

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases (CaSR Biomedicine)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer...
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 13

 TERMINÉ 

FRAGments training NETwork (FRAGNET)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

The promise of more efficient lead discovery is fuelling the enthusiasm for fragment-based lead discovery (FBLD). In this approach, highly sensitive biochemical and biophysical screening technologies are being used to detect the low affinity binding of low molecular weight compounds (the so-called fragments) to protein targets that are involved in pathophysiological processes. By investigating the...
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 9

 TERMINÉ 

Interdisciplinary Network for Dementia Utilising Current Technology (INDUCT) (INDUCT)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

Dementia raises complex challenges for people with dementia, their families, and society. The European Parliament has called for investment in high quality, innovative technology research to improve dementia care but so far there has been little benefit because research has generally been limited, small scale and methodologically flawed. In particular: the poor understanding between research and b...
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 9

 TERMINÉ 

Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology. (Muscle stress relief)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in ...
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 14

 TERMINÉ 

Solar Energy to Biomass - Optimisation of light energy conversion in plants and microalgae (SE2B)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

In the face of the increasing global consumption of fossil resources, photosynthetic organisms offer an attractive alternative that could meet our rising future needs as clean, renewable, sources of energy and for the production of fine chemicals. Key to the efficient exploitation of these organisms is to optimise the conversion of Solar Energy into Biomass (SE2B). The SE2B network deals with this...
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 12

 TERMINÉ 

European Gram Negative Antibacterial Engine (ENABLE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2020,

The intensive use and misuse of antibiotics has resulted in some level of antibiotic resistance in essentially all human bacterial pathogens. There is a growing concern that the loss of therapeutic options will present us with a post-antibiotic era where present and future medical advances are negated. Resistant bacteria dramatically reduce the possibilities of treating infections effectively, a...
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 42

 TERMINÉ 

European Prevention of Alzheimer’s Dementia Consortium (EPAD)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras...
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 40

 TERMINÉ 

Spinal Exoskeletal Robot for Low Back Pain Prevention and Vocational Reintegration (SPEXOR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Low-back pain is the leading cause of worker absenteeism after the common cold, accounting for 15% of sick leaves and hundreds of millions of lost work days annually [Walking 2.0, Nature, 2015].Most of today's robotic assistive devices are in forms of exoskeletons that augment the motion of legs and arms and neglect the role of spinal column in transferring load from the upper body and arms to the...
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 8

 TERMINÉ 

PROMOTING MENTAL WELLBEING IN THE AGEING URBAN POPULATION: DETERMINANTS, POLICIES AND INTERVENTIONS IN EUROPEAN CITIES (MINDMAP)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Major depressive disorder, dementia, anxiety disorders, and substance abuse affect a substantial part of the European older population. Over 70% of Europeans reside in cities, and this percentage will increase in the next decades. Urbanization and ageing have enormous implications for public mental health. Cities pose major challenges for older citizens, but also offer opportunities for the design...
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 14

 TERMINÉ 

Physical Activity and Nutrition INfluences In ageing (PANINI)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Life expectancy is increasing dramatically, but the period of good health (healthspan) enjoyed by most is not keeping pace, with implications for health, social care, and pensions resulting in estimated costs more than doubling by 2050. Thus, understanding the many factors that contribute to healthy ageing versus frailty, and validating interventions and influencing policy to promote healthy agein...
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 8

 TERMINÉ 

Data-driven models for Progression Of Neurological Disease (EuroPOND)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

EuroPOND will develop a data-driven statistical and computational modeling framework for neurological disease progression. This will enable major advances in differential and personalized diagnosis, prognosis, monitoring, and treatment and care decisions, positioning Europe as world leaders in one of the biggest societal challenges of 21st century healthcare. The inherent complexity of neurologica...
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 9

 TERMINÉ 

The Integrated Initiative of European Laser Research Infrastructures (LASERLAB-EUROPE)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2019,

LASERLAB-EUROPE is the European consortium of major national laser research infrastructures, covering advanced laser science and applications in most domains of research and technology, with particular emphasis on areas with high industrial and social impact, such as bio- and nanophotonics, material analyses, biology and medicine. Recently the field of advanced lasers has experienced remarkable ad...
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 26

 TERMINÉ 

PEOple-centred development approaches in Practical and Learning Environments

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

PEOPLE brings together Higher Education Institutions from the social sciences and industries from the sustainable living and energy sector to jointly develop and integrate people-centred development approaches into research, teaching and learning practices. At the core of the project is the idea that understanding people should become an indispensable part of industrial development processes, as a...
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 9