Plus de 40 projets européens trouvés
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TERMINÉ
Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer (IMMUNOSABR)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,
IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of ra...
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17
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TERMINÉ
Understanding information for legal protection of people against information-induced harms (INFO-LEG)
Date du début: 1 mars 2017, Date de fin: 28 févr. 2022,
Information can harm people. Think of being denied mortgage or insurance based on your grocery shopping or online surfing profile. But what exactly is it in information that is harmful, and how can people be protected? The current legal answer is that protection (data protection principles, rights and obligations) is granted when a) there is information b) about or potentially affecting a person c...
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1
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TERMINÉ
Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in...
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17
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TERMINÉ
Analysing coherence in law through legal scholarship (CLLS)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Coherence of law is created in the writings of legal scholars who systematize rules and principles of law. Their pursuit of coherence is vital for the effectiveness of legal systems. However, coherence of law has almost not been analysed in a systematic, empirical way. The project will therefore develop a methodology that will address coherence across forms (‘sources’) of law (legislation, legal s...
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1
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TERMINÉ
Goal-directed eye-head coordination in dynamic multisensory environments (ORIENT)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
Rapid object identification is crucial for survival of all organisms, but poses daunting challenges if many stimuli compete for attention, and multiple sensory and motor systems are involved in the processing, programming and generating of an eye-head gaze-orienting response to a selected goal. How do normal and sensory-impaired brains decide which signals to integrate (“goal”), or suppress (“dis...
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1
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TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte...
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44
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TERMINÉ
Neural decisions under uncertainty (NOISYDECISIONS)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Virtually anything we sense, think and do is uncertain. For instance, when driving a car, you often need to determine how close you are to the car in front of you. It is near impossible to estimate this distance with absolute certainty – but it is possible to guess and even to estimate the uncertainty associated with that guess. Accordingly, we reduce speed when driving at night, because we realiz...
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1
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TERMINÉ
Middlebrow Enlightenment: Disseminating Ideas, Authors, and Texts in 18th-century Europe (MEDIATE)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Intellectual history has long focused on a small number of authors and conceptual frameworks in studying societal change during the Enlightenment. Historians of the book have similarly restricted their vision, tending to privilege radical, subversive or forbidden texts. Yet ever since Daniel Mornet launched the history of the book approach a century ago, historians have recognized that it was auth...
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1
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TERMINÉ
Stress Resilience and Network-Feedback Training (STRESNET)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Acute stress has a profound impact on cognitive functioning: it raises alertness for threat, yet it impairs our ability to think clearly. Repeated exposure to stressors is furthermore a critical transdiagnostic factor in etiology, relapse, and chronification in almost all psychiatric disorders. We know from animal work at the cellular level how stressors trigger a neurochemical cascade that alters...
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1
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TERMINÉ
Political Apologies across Cultures (APOLOGY)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
In the past decades, there has been a considerable rise in the number of apologies offered by states for injustices and human rights violations. Among transitional justice scholars, there is significant debate about how useful such apologies are. Whereas some have applauded these gestures as an important step in peacemaking processes, others have argued that they may not fit in all cultures and ma...
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1
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TERMINÉ
Participatory Urban Governance between Democracy and Clientelism: Brokers and (In)formal Politics (BROKERS)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
The emergence of participatory governance has resulted in the delegation of governmental responsibilities to citizens. Individuals position themselves as voluntary mediators, or brokers, between the government and their fellow citizens. This research asks: what are the roles of such brokers in participatory urban governance, and how do they influence democratic governance? This study will investig...
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1
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TERMINÉ
Video games for the prevention of depression and anxiety: A 21st century approach to emotional and mental health in adolescents (GEMH)
Date du début: 1 août 2016, Date de fin: 31 juil. 2021,
Depression and anxiety are the most frequently diagnosed mental health problems, leading to devastating long-term outcomes that affect a huge proportion of adolescents across the globe. Effective prevention programs are urgently needed; however, even our most advanced programs often lead to disappointing outcomes. Video games promise a groundbreaking, 21st century innovation: games provide learnin...
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1
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TERMINÉ
CHECKPOINTS IN CHECK: Novel Chemical Toolbox for Local Cancer Immunotherapy (CHEMCHECK)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,
Cancer evades the immune system by generating an immunosuppressive tumour-microenvironment through various mechanisms to enable unhampered growth. Recent breakthroughs in blocking one of these mechanisms – the so called ‘immune checkpoints’ – put cancer immunotherapy back in the spotlights. Although promising, clinical benefits of these checkpoint inhibitors as single treatment has been limited to...
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1
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TERMINÉ
Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy (PRECIOUS)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
PRECIOUS aims at scaling-up biodegradable nanomedicines for multimodal precision cancer immunotherapy.With 3.5 million cancer patients in Europe every year, new cancer medicines are eagerly awaited, notably for prostate and ovarian cancer.Systemically applied new immunotherapies are promising, but their toxicity is a hurdle. Vaccination against cancer is safe but rather disappointing: the microenv...
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11
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TERMINÉ
Visual perception in Context (CONTEXTVISION)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
Everything occurs in a context. We see a car in the context of a street scene and a stove in the context of a kitchen. Context greatly helps the processing of individual objects. Surprisingly however, context hardly plays a role in most models of visual perception, which treat perception as a largely bottom-up categorization process. In this research proposal, I will examine how context changes th...
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1
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TERMINÉ
PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
PROMISS (PRevention Of Malnutrition In Senior Subjects in the EU) is a multi-country project aiming to turn the challenge of tackling malnutrition in community-dwelling older persons into an opportunity for healthy ageing for the future. The PROMISS consortium contains worldwide expertise in epidemiology, clinical trials, geriatrics, nutrition, physical activity, microbiomics, as well as in behavi...
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24
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TERMINÉ
Soil Care for profitable and sustainable crop production in Europe (SOILCARE)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
European crop production is to remain competitive while reducing environmental impacts, requiring development and uptake of effective soil improvingcropping systems. The overall aim of SOILCARE is to identify and evaluate promising soil-improving cropping systems and agronomictechniques increasing profitability and sustainability across scales in Europe. A trans-disciplinary approach will be used ...
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29
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TERMINÉ
PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES. (PANA)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new ef...
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11
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TERMINÉ
Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine (RABYD-VAX)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Rabies is the deadliest disease on earth (99.9% fatality rate). Annually, ~58.000 people die from rabies, more than half of them are children. Many remain unvaccinated because of the high costs and the need for a cold-chain. Likewise, despite the existence of an excellent yellow fever (YF) vaccine, yearly ~30.000 people die of YF. The 80-year old low-tech production process does not allow to produ...
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5
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TERMINÉ
Scaling up Safe Surgery for District and Rural Populations in Africa (SURG-Africa)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
In sub-Saharan Africa 95% of the population has no access to surgical services. In this region surgery – a proven and often life-saving intervention – is only accessible to urban populations, with only one surgeon per 2.5 million people in rural areas. Emerging evidence demonstrates that major surgery can be undertaken safely and effectively at district hospitals, making it accessible to otherwise...
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6
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TERMINÉ
Paediatric Clinical Research Infrastructure Network (PedCRIN)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group...
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16
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TERMINÉ
3-O-sulfated heparan sulfate translocation in altered membrane biology: A newstrategy for early population screening and halting Alzheimer’s neurodegeneration (ArrestAD)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic co...
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8
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TERMINÉ
Comorbid Conditions of Attention deficit / hyperactivity disorder (CoCA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders,...
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17
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TERMINÉ
Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar...
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19
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TERMINÉ
Microbiology of extremely acidic terrestrial volcanic ecosystems (VOLCANO)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Terrestrial mud volcanos are extreme environments with pH values below even 1, with temperatures up to 70 ºC. They represent ‘hotspots’ of greenhouse gas emissions. Despite the hostile conditions, mud volcanos harbour very unique microbial communities involved in the cycling of elements like carbon, hydrogen, sulfur, and nitrogen. Microbial communities in extreme environments are characterized by ...
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1
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TERMINÉ
European Academy for Biomedical Science (ENABLE)
Date du début: 1 juil. 2016, Date de fin: 31 déc. 2020,
The proposed European Academy for Biomedical Science (ENABLE) consortium will connect aspiring European researchers of tomorrow with prominent scientists of today, in particular to inspire and to give them the necessary tools to follow in their footsteps. ENABLE will organize peer-reviewed symposia celebrating European life science achievements from molecule to man/patient. These symposia will hav...
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6
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TERMINÉ
Reproducing Europe: Migrant Parenting and Questions of Citizenship (MigrantParents)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
This project is an anthropological study of citizenship in a Europe where the presence of migrants has increasingly come to be seen as a burden or threat. This project examines how citizenship is debated, produced and negotiated in this context. It does so through a multilevel study of debates, interventions and practices related to migrant parenting in Paris, Milan and Amsterdam. The experiences ...
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1
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TERMINÉ
Continuous Resolution and Deracemization of Chiral Compounds by Crystallization (CORE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to o...
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8
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TERMINÉ
Enriched communication across the lifespan (ENRICH)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
"Speech is a hugely efficient means of communication: a reduced capacity in listening or speaking creates a significant barrier to social inclusion at all points through the lifespan, in education, work and at home. Hearing aids and speech synthesis can help address this reduced capacity but their use imposes greater listener effort. The fundamental objective of the ETN "Enriched communication acr...
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8
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TERMINÉ
Spintronic-Photonic Integrated Circuit platform for novel Electronics (SPICE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
The main objective of SPICE is to realize a novel integration platform that combines photonic, magnetic and electronic components. Its validity will be shown by a conceptually new spintronic-photonic memory chip demonstrator with 3 orders of magnitude higher write speed and 2 orders of magnitude lower energy consumption than state-of-the-art spintronic memory technologies. This enables, e.g., futu...
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6
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TERMINÉ
Cancer treatment during pregnancy: from fetal safety to maternal efficacy (CRADLE)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,
The evolution in drug regulation of the last 50 years has left pregnant women and their fetuses orphaned. This is particularly problematic for cancer during pregnancy, which raises a difficult and conflicting medical ethical decision process and which has recently become increasingly frequent. In 2012 we published the first prospective study indicating that antenatal exposure to cancer treatment c...
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2
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TERMINÉ
Regulation of mitochondrial expression (REMIX)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of ATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrial genes encoded by either genome could caus...
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9
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TERMINÉ
Imaging the Event Horizon of Black Holes (BLACKHOLECAM)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2020,
Gravity is successfully described by Einstein’s theory of general relativity (GR), governing the structure of our entire universe. Yet it remains the least understood of all forces in nature, resisting unification with quantum physics. One of the most fundamental predictions of GR are black holes (BHs). Their defining feature is the event horizon, the surface that light cannot escape and where tim...
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6
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TERMINÉ
The Extensive and Ubiquitous Role of Polycyclic Aromatic Hydrocarbons (PAHs) in Space (EUROPAH)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,
Large Polycyclic Aromatic Hydrocarbon (PAH) molecules are deeply interwoven in the fabric of the Universe and lock up ~15% of the elemental carbon in the interstellar medium (ISM) of galaxies. They dominate the mid-infrared emission characteristics of galaxies that can be used to trace star formation locally as well as in the early universe, they influence the phase structure of the ISM and the st...
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9
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TERMINÉ
Professional cross-priming for ovary and prostate cancer (PROCROP)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would ...
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8
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TERMINÉ
Making Scientific Inferences More Objective (Objectivity)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
"What makes scientific inferences trustworthy? Why do we think that scientific knowledge is more than the subjective opinion of clever people at universities? When answering these questions, the notion of objectivity plays a crucial role: the label "objective" (1) marks an inference as unbiased and trustworthy and (2) grounds the authority of science in society. Conversely, any challenge to this i...
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1
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TERMINÉ
Greenhouse Gas Mitigation through Advanced Nitrogen Removal Technology (GREENT)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Human activities have severe impacts on the biological carbon and nitrogen cycles. The most important consequences of these are global warming and water pollution. Wastewater treatment technology, in particular nitrogen removal systems, improved considerably in the last decade. The application of anaerobic ammonium oxidizing (anammox) bacteria in oxygen-limited granules has the potential to turn w...
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2
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TERMINÉ
Size matters: scaling principles for the prediction of the ecological footprint of biofuels (SIZE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
There is a major scientific and societal challenge in quantifying and reducing ecological footprints of products. Ecological footprint calculations suffer severely from a limited availability of data, such as the amount of energy and materials associated with the production, use and disposal of products. Furthermore, ecological footprints pertaining to biodiversity are typically biased towards a l...
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1
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TERMINÉ
MidFrontal Cortex Theta Oscillations: Causes and Consequences (MidFrontalTheta2.0)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
While reading this text, pat your head and rub your stomach (if someone sees you, tell them it's OK; you're doing science). Right now you are engaging in an action that must be actively monitored and quickly adjusted to avoid making mistakes. Over the past five years, my collaborators and I discovered that there is a specific pattern of brain electrical activity that occurs during response conflic...
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1
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TERMINÉ
Commitment, maturation and infectivity of sexual stage malaria parasites in natural infections (COSMIC)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Background: One of the major challenges for malaria control and elimination is the phenomenally efficient spread of malaria through sexual stage malaria parasites (gametocytes). The epidemiology and dynamics of gametocytes are poorly understood: it is presently unknown when commitment to gametocytes first occurs during infections and what intrinsic or extrinsic factors influence gametocyte product...
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