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 TERMINÉ 

High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny (FatemapB)

Date du début: 1 oct. 2017, Date de fin: 30 sept. 2022,

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and t...
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 1

 TERMINÉ 

Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease (NASCENT)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Proposal summaryType 2 diabetes and cardiovascular disease are devastating and costly morbidities whose prevalences are increasing rapidly around the world. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. As numerous clinical trials have shown, lifestyle modification is by far the best way to prevent these diseases, with lifestyle being twi...
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 1

 TERMINÉ 

Neural circuits underlying complex brain function across animals - from conserved core concepts to specializations defining a species’ identity (BrainInBrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The core function of all brains is to compute the current state of the world, compare it to the desired state of the world and select motor programs that drive behavior minimizing any mismatch. The circuits underlying these functions are the key to understand brains in general, but so far they are completely unknown. Three problems have hindered progress: 1) The animal’s desired state of the world...
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 1

 TERMINÉ 

Parallel network-based biocomputation: technological baseline, scale-up and innovation ecosystem (Bio4Comp)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Many technologically and societally important mathematical problems are intractable for conventional, serial computers. Therefore, a significant need exists for parallel-computing approaches that are capable to solve such problems within reasonable time frames. Recently, part of our consortium demonstrated proof-of-principle of a parallel-computation system in which a given combinatorial problem i...
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 6

 TERMINÉ 

Erasmus Mundus Joint Master Degree in Food Innovation & Product Design

Date du début: 30 sept. 2016, Date de fin: 30 sept. 2021,

The EMJMD FIPDes is a 2-year programme in Food Innovation & Product Design. It is the first course created to tackle the global challenges of food innovation along with product design and packaging. FIPDes trains a new generation of food professionals capable of working across borders, with an inclusive vision of innovation to create sound, sustainable and healthy food solutions for the future gen...
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 4

 TERMINÉ 

Deciphering cell heterogeneity in tumors using arrays of nanowires to controllably poke single cells in longitudinal studies (NanoPokers)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Cancer is responsible for 20% of all deaths in Europe. Current cancer research is based on cell ensemble measurements or on snapshot studies of individual cells. However, cancer is a systemic disease, involving many cells that interact and evolve over time in a complex manner, which cell ensemble studies and snapshot studies cannot grasp. It is therefore crucial to investigate cancer at the single...
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 1

 TERMINÉ 

Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits (ComplexSex)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

The origin and evolution of sexual reproduction and sex differences represents one of the major unsolved problems in evolutionary biology, and although much progress had been made both via theory and empirical research, recent data suggest that sex chromosome evolution may be more complex than previously thought. The concept of sexual antagonism (when there is a positive intersexual genetic correl...
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 1

 TERMINÉ 

Optimal diversity in immunity – to overcome pathogens and maximize fitness; moving from correlative associations to a more mechanistic understanding using wild songbirds. (Optimal-Immunity)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

The Major Histocompatibility Complex (MHC) genes are intensively studied genes in association with disease resistance. MHC proteins are essential for initiating every adaptive immune response and MHC is probably the most extreme example of how selection from a wide range of pathogens maintains high diversity in host immunity genes. However, the functions of the MHC proteins are only known in human...
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 1

 TERMINÉ 

Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers (inHForm)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Heart failure is a leading cause of morbidity and mortality in the aging European populations. It is the end-stage of myocardial and valvular disease, arising from loss of viable or functional muscle cells in the heart. Therapy is complicated by the multitude of causes and comorbidities of heart failure. New therapeutic targets and clinical biomarkers to individually tailor therapy (‘precision med...
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 1

 TERMINÉ 

Innovative Network for Monte Carlo Event Generators for LHC Physics (MCnetITN3)

Date du début: 1 avr. 2017, Date de fin: 31 mars 2021,

We propose a European Training Network that will provide a total of 540 ESR-months of training in Monte Carlo event generator physics and techniques, and related applications in experimental particle physics.Monte Carlo event generators are central to high energy particle physics. They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theo...
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 9

 TERMINÉ 

Drivers and impacts of invertebrate herbivores across forest ecosystems globally. (ECOHERB)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Forests slow global climate change by absorbing atmospheric carbon dioxide but this ecosystem service is limited by soil nutrients. Herbivores potentially alter soil nutrients in a range of ways, but these have mostly only been recorded for large mammals. By comparison, the impacts of the abundant invertebrates in forests have largely been ignored and are not included in current models used to gen...
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 1

 TERMINÉ 

MEthane goes MObile - MEasurements and MOdelling (MEMO2)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

Mitigation of climate change is a key scientific and societal challenge and also a headline target of the EU2020 strategy. Strong reductions in greenhouse gas emissions are necessary to reach the global warming target agreed on at the 2015 United Nations Convention of Parties in Paris. Such emission reductions can only be achieved if sources are properly quantified and mitigation efforts are verif...
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 9

 TERMINÉ 

Mathematical aspects of three-dimensional water waves with vorticity (3DWATERWAVES)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

The goal of this project is to develop a mathematical theory for steady three-dimensional water waves with vorticity. The mathematical model consists of the incompressible Euler equations with a free surface, and vorticity is important for modelling the interaction of surface waves with non-uniform currents. In the two-dimensional case, there has been a lot of progress on water waves with vorticit...
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 1

 TERMINÉ 

Innovative Nanowire DEvicE Design (INDEED)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowl...
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 12

 TERMINÉ 

Discovery strategies for Dark Matter and new phenomena in hadronic signatures with the ATLAS detector at the Large Hadron Collider (DARKJETS)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

The Standard Model of Particle Physics describes the fundamental components of ordinary matter and their interactions. Despite its success in predicting many experimental results, the Standard Model fails to account for a number of interesting phenomena. One phenomenon of particular interest is the large excess of unobservable (Dark) matter in the Universe. This excess cannot be explained by Stan...
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 1

 TERMINÉ 

Readiness of ICOS for Necessities of integrated Global Observations (RINGO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The proposed project “Readiness of ICOS for Necessities of integrated Global Observations” (RINGO) aims to further development of ICOS RI and ICOS ERIC and foster its sustainability. The challenges are to further develop the readiness of ICOS RI along five principal objectives: 1. Scientific readiness. To support the further consolidation of the observational networks and enhance their quality. Th...
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 26

 TERMINÉ 

Towards a deepened understanding of combustion processes using advanced laser diagnostics (TUCLA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The field of combustion is of utmost societal/industrial importance while at the same time posing outstanding scientific challenges. In order to handle these, it is extremely important to develop and apply non-intrusive laser-diagnostic techniques with high spatial and temporal resolution for measurements of key parameters such as species concentrations and temperatures. Such techniques have been ...
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 1

 TERMINÉ 

Synaptic dysfunction in Neurodegenerative Diseases (SYNDEGEN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, a...
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 8

 TERMINÉ 

Integrated inter-sector framework to increase the thermal resilience of European workers in the context of global warming (HEAT-SHIELD)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Environmental heating is a growing challenge for our community and problems are already experienced by millions of Europeans during the summertime and aggravated during heat waves or occupational settings. In addition to the well-known health risks related to severe heat stress, a number of studies have confirmed significant loss of productivity due to hyperthermia. Even if countries adopt the EU ...
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 21

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m...
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 13

 TERMINÉ 

Learning to See in a Dynamic World (SEED)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The goal of SEED is to fundamentally advance the methodology of computer vision by exploiting a dynamic analysis perspective in order to acquire accurate, yet tractable models, that can automatically learn to sense our visual world, localize still and animate objects (e.g. chairs, phones, computers, bicycles or cars, people and animals), actions and interactions, as well as qualitative geometrical...
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 1

 TERMINÉ 

Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,

The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi...
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 25

 TERMINÉ 

Realising Innovation in Transitions for Decarbonisation (REINVENT)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

It is high time for the EU to develop pathways and strategies for decarbonisation also in emissions intensive sectors such as steel, plastics, paper, and meat and dairy. These are sectors where low carbon transitions are still relatively unexplored. Some progressive companies and other actors are just beginning to consider such pathways. The overall aim of REINVENT is to help Europe achieve its lo...
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 5

 TERMINÉ 

European Training Network for Cell-based Regenerative Medicine (Training4CRM)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

The main objective of Training4CRM is to train a new generation of 15 highly inter-disciplinary early stage researchers at the highest international level and quality, who will be immediately employable in both the academic and industrial sectors due to their highly sought after cross- and interdisciplinary insights and expertise. Training4CRM addresses existing gaps within Cell-based Regenerative...
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 9

 TERMINÉ 

Coordinated Research in Earth Systems and Climate: Experiments, kNowledge, Dissemination and Outreach (CRESCENDO)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system ...
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 25

 TERMINÉ 

Collider Phenomenology and Event Generators (MorePheno)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

Collider physics is about exploring the smallest constituents of matter, and unravelling the basic laws of the Universe. Unfortunately there can be a huge gap between a one-line formula of a fundamental theory and the experimental reality it implies. Phenomenology is intended to fill that gap, e.g. to explore the consequences of a theory such that it can be directly compared with data. Nowhere is ...
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 1

 TERMINÉ 

Nature Based Urban Innovation (NATURVATION)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Nature-Based Solutions (NBS) have the potential to respond to climate change, enhance biodiversity and improve environmental quality while contributing to economic regeneration and social well-being. Yet there is a substantial gap between the promise of NBS and their uptake. To unlock the potential of NBS for sustainable urban development, NATURVATION will take a transdisciplinary, internationally...
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 14

 TERMINÉ 

MACRO CASCADE – Cascading Marine Macroalgal Biorefinery (MACRO CASCADE)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

MACRO CASCADE will prove the concept of the cascading marine macroalgal biorefinery i.e. a production platform that covers the whole technological chain for processing sustainable cultivated macro-algae biomass – also known as seaweed - to highly processed value added products. The macro-algae biorefinery will be capable of processing multiple feedstocks, by deploying a range of mechanical, phy...
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 13

 TERMINÉ 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th...
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 20

 TERMINÉ 

Linking Cardiometabolic Disease and Cancer in the Level of Genetics, Circulating Biomarkers, Microbiota and Environmental Risk Factors (BIOMENDELIAN)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through ...
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 1

 TERMINÉ 

Baltic Consortium on Promoting Gender Equality in Marine Research Organisations (Baltic Gender)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Baltic Gender is a consortium of research organisations and higher education institutions from the Baltic Sea Region aiming at reducing gender segregation and gender inequalities in Marine Science and Technology. The diversity of the consortium members (from Nordic, Continental and Eastern countries) with regard to gender equality policies and practices as well as gatekeeping provides an excellent...
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 8

 TERMINÉ 

Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders (UNEXPECTED)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Mechanisms of self-renewal in hematopoietic stem cells (HSCs) have been subject to intense studies during the last decades. However, this is still a poorly defined process and very limited progress has been made in the long sought goal of expanding HSCs ex vivo to allow for critical improvements of bone marrow transplantation procedures for cancer patients and potentially a broader use of HSCs in ...
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 1

 TERMINÉ 

HARMONIzation and integrative analysis of regional, national and international Cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making (HarmonicSS)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,

HarmonicSS vision is to create an International Network and Alliance of partners and cohorts, entrusted with the mission of addressing the unmet needs in primary Sjogren Syndrome; working together to create and maintain a platform with open standards and tools, designed to enable secure storage, governance, analytics, access control and controlled sharing of information at multiple levels along wi...
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 39

 TERMINÉ 

Linking Up Environment, Health and Climate for Inter-sector Health Promotion and Disease Prevention in a Rapidly Changing Environment (BlueHealth)

Date du début: 1 janv. 2016, Date de fin: 30 juin 2020,

The BlueHealth Consortium brings together a multi-disciplinary team of experts reaching across all 28 European Union countries. The proposed 4.5 year BlueHealth Project takes an international, interdisciplinary and multi-sector approach to health promotion and disease prevention by investigating the relationship between the EU’s ‘blue infrastructure’ and the health and well-being of its citizens. ...
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 13

 TERMINÉ 

Virus-X: Viral Metagenomics for Innovation Value (Virus-X)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Biological sequence diversity in nowhere as apparent as in the vast sequence space of viral genomes. The Virus-X project will specifically explore the outer realms of this diversity by targeting the virosphere of selected microbial ecosystems and investigate the encoded functional variety of viral gene products. The project is driven by the expected large innovation value and unique properties of ...
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 15

 TERMINÉ 

Alzheimer Disease - gut connection (AD-gut)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzhe...
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 6

 TERMINÉ 

Dexterous Transradial Osseointegrated Prosthesis with neural control and sensory feedback (DeTOP)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This project addresses the scientific, technological and clinical problem of recovery of hand function after amputation. Despite decades of research and development on artificial limbs and neural interfaces, amputees continue to use technology for powered prostheses developed over 40 years ago, namely myoelectric prostheses controlled via superficial electrodes. These devices do not purposely prov...
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 7

 TERMINÉ 

Detailed Characterization of Spray Systems using Novel Laser Imaging Techniques (Spray-Imaging)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

The multiple scattering of light is a complex phenomenon, commonly encountered but rarely desired. In imaging it induces strong blurring on the recorded photographs, limiting the range of applicability and accuracy of modern optical instruments. A typical example concerns the laser diagnostics of spray systems. The PI has revealed in 2008 a technique based on structured illumination with the impor...
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 1

 TERMINÉ 

Methodologies and Data mining techniques for the analysis of Big Data based on Longitudinal Population and Epidemiological Registers (LONGPOP)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

European societies face rapid social changes, challenges and benefits, which can be studied with traditional tools of analysis, but with serious limitations. This rapid transformation covers changes in family forms, fertility, the decline of mortality and increase of longevity, and periods of economic and social instability. Owing to population ageing across Europe, countries are now the experienc...
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 10

 TERMINÉ 

Next generation of superhard non-CRM materials and solutions in tooling (Flintstone2020)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

Flintstone2020 aims to provide a perspective for the replacement of two important CRMs – tungsten (W) and cobalt (Co) – which are the main constituents for two important classes of hard materials (cemented carbides/WC-Co, and PCD/diamond-Co), by developing innovative alternative solutions for tooling operating under extreme conditions. Fundamental knowledge on mechanical properties and wear of dif...
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 9