5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Innovative drugs targeting IDO molecular dynamics in autoimmunity and neoplasia (DIDO)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Catabolism of amino acids is an ancient survival strategy that also controls immune responses in mammals. Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions, including autoimmune diseases, in which it is often defective, and neoplasia, in which it promotes immune unresponsiveness. The PI’s ...
Voir le projet
1
Participant partenaire
TERMINÉ
Genetic High Throughput Screenings by random mutagenesis to identify Plasmodium falciparum critical genes for asexual growth, sexual differentiation and virulence affecting host immune responses (GeneticHTS reveal Pf)
Date du début: 1 févr. 2011, Date de fin: 21 févr. 2018,
Malaria is a global health problem that demands immediate practical actions to contain the high infection and mortality rates caused by Plasmodium species. Protective vaccine is still missing. Available drugs diminish their impact against Plasmodium as resistances are rising and expanding on the territories. While no vaccine of the current portfolio showed ideal protection and low-cost feasibility ...
Voir le projet
2
Participants partenaires
TERMINÉ
Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy (FunMeta)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (including fungi) and individual variations in the microbiome influence host health and disease. The fact that fungi are capable of colonizing almost every niche within the human body suggests that they must possess particular immune adaptation mechanisms, the breakdown of which may result in fatal fungal infect ...
Voir le projet
3
Participants partenaires
TERMINÉ
"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices" (ALLFUN)
Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,
"The ALLFUN proposal aims at defining the cellular and molecular mechanisms by which ubiquitous airborne or commensal fungi contribute to immune homeostasis and its dysregulation leading to allergy and inflammatory diseases. Breakthroughs in understanding how mucosal homeostasis is established, maintained or disrupted in the presence of fungi should be sources of new therapeutic targets and drugs ...
Voir le projet
14
Participants partenaires
TERMINÉ
Correlating protection against malaria with serum profiles against Plasmodium falciparum antigen repertoires (FIGHTMAL)
Date du début: 1 juin 2008, Date de fin: 31 mai 2012,
"People living in malaria endemic areas develop, with time, a form of immunity to infection and clinical disease mediated by antibodies directed against P. falciparum antigens. Currently there are no assays or clinical parameters that predict whether an exposed person is protected against malaria. This represents a major obstacle for vaccine development. Here research institutions and industrial p ...
Voir le projet