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 EN COURS 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 EN COURS 

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

 EN COURS 

Mechanisms and regulation of inflammasome-associated programmed cell death (PyroPop)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Programmed cell death is essential for homeostasis, and its deregulation contributes to human disease. Inflammasome-induced pyroptosis of infected macrophages contributes to host defense against infections, but the concomitant release of inflammatory danger signals and leaderless cytokines is detrimental in chronic inflammatory diseases. The central hypothesis of the PyroPop ERC Consolidator proje ...
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 1

 EN COURS 

Memory in biological regulatory circuits (YEASTMEMORY)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and ye ...
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 1

 EN COURS 
Cells communicate with the outside world through proteins anchored in their plasma membrane and hereto constantly adjust their plasma membrane (PM) proteome. In this adjustment process, removing proteins from the PM mainly occurs through clathrin-mediated endocytosis (CME). Mechanistically however, this process remains poorly understood in plants.A recent study from my group has shown that, in con ...
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 1

 EN COURS 
Regulatory T cells (Tregs) are formed through the expression of the transcription factor Foxp3 in T cells, resulting in the rewiring of the cell function into an immunosuppressive phenotype. Recently, it has been proposed that Tregs also have additional tissue-specific physiological roles when resident in different tissues. For example, tissue-specific Tregs residing in the muscle and adipose tiss ...
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 1

 EN COURS 
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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 19

 EN COURS 
Sustainable food security and increasing availability of plant biomass for human nutrition and bioindustries is the key challenge for the coming decades. The analysis of crop performance with respect to structure, function, quality and interaction with the environment (“phenotyping”) remains the bottleneck for the exploitation of crop genetic diversity required for the enhancement of plant product ...
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 9

 EN COURS 
Neurodegeneration is characterized by misfolded proteins and dysfunctional synapses. Synapses are often located very far away from their cell bodies and they must therefore largely independently cope with the unfolded, dysfunctional proteins that form as a result of synaptic activity and stress. My hypothesis is that synaptic terminals have adopted specific mechanisms to maintain robustness over ...
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 1

 EN COURS 
Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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 13

 EN COURS 
The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T ...
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 2

 TERMINÉ 

Bacterial Amyloid Secretion: Structural Biology and Biotechnology. (BAS-SBBT)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria. Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires ...
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 1

 TERMINÉ 
Amyloid-like protein aggregation is a process of protein assembly via the formation of intermolecular β-structures by short aggregation prone sequence regions. This occurs as an unwanted side-reaction of impaired protein folding in disease, but also for the construction of natural nanomaterials. Aggregates appear to be strongly enriched in particular proteins, suggesting that the assembly process ...
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 1

 TERMINÉ 
Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intrica ...
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 1

 TERMINÉ 

Alzheimer Disease - gut connection (AD-gut)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzhe ...
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 6

 TERMINÉ 

Exploiting Protein Complexes that Induce Cell-death (EPIC)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by ...
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 5

 TERMINÉ 
Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism ...
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 9

 TERMINÉ 

MASS Spectrometry TRaining network for Protein Lipid adduct ANalysis (MASSTRPLAN)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools. Chronic inflammatory diseases such as diabetes, cardiovascular disease (CVD) & cancer ...
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 12

 TERMINÉ 
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 
"DNA methylation was originally described in the 1970s as an epigenetic mark involved in transcriptional silencing, but the existence of DNA demethylation and the enzymes involved in this process were only recently discovered. In particular, it was established that TET hydroxylases catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxyg ...
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 1

 TERMINÉ 

Gamification of participatory science for training and education purposes (GAPARS)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2019,

Creating effective ways for citizen science is immensely important. Scientists in all fields increasingly rely on active public participation for experiments and analyses of complex and/or massive data, and the outreach and education possibilities of citizen science are enormous.Yet there are three key issues for any citizen science project: (i) reach out to a sufficiently large audience, (ii) low ...
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 9

 TERMINÉ 
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neurons. As for other neurodegenerative disorders, translation of newly acquired biological insights into therapies has been difficult. In the current project we intend to contribute to the development of therapeutic approaches for ALS. We want to generate novel models, identify new therapeutic targets for interv ...
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 1

 TERMINÉ 

Aberrant RNA degradation in T-cell leukemia (ART)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"The deregulation of transcription is an important driver of leukemia development. Typically, transcription in leukemia cells is altered by the ectopic expression of transcription factors, by modulation of signaling pathways or by epigenetic changes. In addition to these factors that affect the production of RNAs, also changes in the processing of RNA (its splicing, transport and decay) may contri ...
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 1

 TERMINÉ 

Function of Chemosensory Circuits (CHEMOSENSORYCIRCUITS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

Smell and taste are the least studied of all senses. Very little is known about chemosensory information processing beyond the level of receptor neurons. Every morning we enjoy our coffee thanks to our brains ability to combine and process multiple sensory modalities. Meanwhile, we can still review a document on our desk by adjusting the weights of numerous sensory inputs that constantly bombard o ...
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 2

 TERMINÉ 
Most biotechnological therapeutics used in the clinic today and under current development, are of protein nature. Eukaryotic expression systems (such as yeasts and mammalian cells) for these therapeutic proteins add carbohydrate moieties (glycans) to the proteins, and these glycans strongly modulate the protein's in vivo biodistribution and therapeutic efficacy. Until recently, no adequate tools w ...
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 1

 TERMINÉ 
"Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. I ...
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 1

 TERMINÉ 

Atlas of leaf growth regulatory networks in MAIZE (AMAIZE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Understanding how organisms regulate size is one of the most fascinating open questions in biology. The aim of the AMAIZE project is to unravel how growth of maize leaves is controlled. Maize leaf development offers great opportunities to study the dynamics of growth regulatory networks, essentially because leaf development is a linear system with cell division at the leaf basis followed by cell ...
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 1

 TERMINÉ 
Based on an international team derived from the COST action BM1003 (www.cost-bm1003.info, 2011-2014) and thus relying on consolidated group interactions and synergies and on a unique combination of chemistry, biology, biophysics, biochemistry and pharmacology expertise, the TOLLerant project aims to gain information on molecular aspects of TLR4 activation and signaling by using synthetic and natur ...
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 10

 TERMINÉ 

The Algal Microbiome: Friends and Foes (ALFF)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Algal aquaculture is developing exponentially worldwide, with multiple applications in the food, chemical and pharmaceutical industries. Current research in algal biotechnology mostly focuses on metabolite discovery, aquaculture yield improvement and engineering bottlenecks. However, agronomical experience shows that controlling the interaction of land crops with mutualistic or pathogenic microbes ...
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 10

 TERMINÉ 
Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity. The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesi ...
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 1

 TERMINÉ 

Ribosome defects in cancer (RIBOCANCER)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

"Cancer cells are defective in vital cell functions such as cell cycle control and response to growth signals. We found that cancer cells acquire defects in yet another vital function: translation of mRNA into proteins. We saw that 9.8% of children with T-cell leukemia (T-ALL) harbor acquired mutations in the ribosome, the cellular protein translation factory. We found mutations in RPL10, RPL5 and ...
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 2

 TERMINÉ 

Migration - Challenge of Modernity

Date du début: 31 déc. 2016, Date de fin: 30 déc. 2018,

"Migration - Challenge of Modernity" is two stages Erasmus+ project aiming cover, explore, discuss and deal with integration related challenges linked to the migration process. Creating network of the civic organizations working or willing to work in the field, promote new tools and methodology among youth workers and NGO workers in order to strengthen the integration and peace building process in ...
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 8

 TERMINÉ 

Functional Analysis of Dopamine Prediction Error Circuits (DopaPredict)

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2018,

One of the key goals in neuroscience is to understand how neural activity generates behavior. Electrophysiological recordings have provided great insights into this relationship, but they cannot resolve the contribution of specific neuronal cell types. Moreover, it has been notoriously difficult to move beyond correlation and demonstrate the functional significance of neural firing for specific be ...
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 1

 TERMINÉ 

Metagenomics in Cardiometabolic Diseases (METACARDIS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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 18

 TERMINÉ 
"The long-term establishment of ancient organisms that have undergone whole genome duplications has been exceedingly rare. On the other hand, tens of thousands of now-living species are polyploid and contain multiple copies of their genome. The paucity of ancient genome duplications and the existence of so many species that are currently polyploid provide an interesting and fascinating enigma. A q ...
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 1

 TERMINÉ 

Learn, Create and Communicate

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

We want to apply for a project that would focus on creativity and culture. The reason for this is our experience that the arts and crafts haven´t been prioritized at schools during the recent years, though the industry and commerce want people entering employment to show powers of innovation, initiative and problem solving. We also felt that many young people today don´t know much about their own ...
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 6

 TERMINÉ 

Stronger Parents - Healthier Communities

Date du début: 1 sept. 2016, Date de fin: 31 août 2018,

Partnership:Ceutí municipality, Spain. Local authority.Viborg municipality, Denmark. Local authority.ALIAT, Romania. Leading NGO in the addiction field (alcohol and other drugs).Gmina Miejska Ilawa (Poland). Local authority.Iskenderum Youth and Education Association (Turkey). Non-for-profit Association with a wide experience with disadvantged groups (including inmigrants from Syria).Euro-Net (Ital ...
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 7

 TERMINÉ 

Formar&Innovar en Europa

Date du début: 1 sept. 2016, Date de fin: 31 août 2018,

IES Andrés Benitez was stablished in 1986/87. The school offers all levels of education from compulsory secondary education to Initial and Higher VET courses with specialisations in Commerce, Hairdressing, Esthetics, Electromechanics and welding, Administration and others.We will offer our student, 24 mobilities for a working period of 3 month in England and Italy. The grants will be offer to th ...
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 8

 TERMINÉ 
Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape s ...
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 2

 TERMINÉ 
This proposal addresses the call topic ‘Advancing bioinformatics to meet biomedical and clinical needs’ (PHC-32-2014), with the focus on the standardization, dissemination and meta-analysis of cell migration data. Cell migration is the fundamental process in medically highly relevant topics, including morphogenesis, immune function, wound healing, and cancer metastasis, and the study of cell migra ...
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 10